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Anti-NMDA receptor encephalitis: still unknown and underdiagnosed by physicians and especially by psychiatrists?
Acta Clin Belg. 2018 Oct; 73(5):364-367.AC

Abstract

Anti-NMDA receptor encephalitis is an autoimmune disorder confirmed by the presence of antibodies against the NMDA-receptor in serum or CSF. This case report describes a young woman with anti-NMDA receptor encephalitis, who presented with prominent psychiatric symptoms. There was a crucial delay in diagnosis and necessary treatment due to the fact that the clinical presentation was diagnosed and treated as a first psychotic episode. Physicians and especially psychiatrists, should consider the possibility of an autoimmune encephalitis in their differential diagnosis in every new onset psychotic episode with rapid progression, the presence of pathognomonic orofacial dyskinesia, the lack of psychiatric history, and the non-responding to psychopharmacological treatment. Early diagnosis and treatment is essential for recovery and may improve the prognosis.

Authors+Show Affiliations

a Department of Psychiatry , Ghent University Hospital , Ghent , Belgium.b Department of Neurology , Ghent University Hospital , Ghent , Belgium.c Psychiatric Clinic Caritas , Ghent , Belgium.d Department of Physical Medicine and Rehabilitation , Ghent University Hospital , Ghent , Belgium.a Department of Psychiatry , Ghent University Hospital , Ghent , Belgium.a Department of Psychiatry , Ghent University Hospital , Ghent , Belgium.a Department of Psychiatry , Ghent University Hospital , Ghent , Belgium.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

29050531

Citation

Hermans, Tine, et al. "Anti-NMDA Receptor Encephalitis: Still Unknown and Underdiagnosed By Physicians and Especially By Psychiatrists?" Acta Clinica Belgica, vol. 73, no. 5, 2018, pp. 364-367.
Hermans T, Santens P, Matton C, et al. Anti-NMDA receptor encephalitis: still unknown and underdiagnosed by physicians and especially by psychiatrists? Acta Clin Belg. 2018;73(5):364-367.
Hermans, T., Santens, P., Matton, C., Oostra, K., Heylens, G., Herremans, S., & Lemmens, G. M. D. (2018). Anti-NMDA receptor encephalitis: still unknown and underdiagnosed by physicians and especially by psychiatrists? Acta Clinica Belgica, 73(5), 364-367. https://doi.org/10.1080/17843286.2017.1392077
Hermans T, et al. Anti-NMDA Receptor Encephalitis: Still Unknown and Underdiagnosed By Physicians and Especially By Psychiatrists. Acta Clin Belg. 2018;73(5):364-367. PubMed PMID: 29050531.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-NMDA receptor encephalitis: still unknown and underdiagnosed by physicians and especially by psychiatrists? AU - Hermans,Tine, AU - Santens,Patrick, AU - Matton,Celine, AU - Oostra,Kristine, AU - Heylens,Gunter, AU - Herremans,Sarah, AU - Lemmens,Gilbert M D, Y1 - 2017/10/19/ PY - 2017/10/21/pubmed PY - 2019/1/5/medline PY - 2017/10/21/entrez KW - Anti-NMDA receptor encephalitis KW - acute psychosis KW - catatonia KW - orofacial dyskinesia SP - 364 EP - 367 JF - Acta clinica Belgica JO - Acta Clin Belg VL - 73 IS - 5 N2 - Anti-NMDA receptor encephalitis is an autoimmune disorder confirmed by the presence of antibodies against the NMDA-receptor in serum or CSF. This case report describes a young woman with anti-NMDA receptor encephalitis, who presented with prominent psychiatric symptoms. There was a crucial delay in diagnosis and necessary treatment due to the fact that the clinical presentation was diagnosed and treated as a first psychotic episode. Physicians and especially psychiatrists, should consider the possibility of an autoimmune encephalitis in their differential diagnosis in every new onset psychotic episode with rapid progression, the presence of pathognomonic orofacial dyskinesia, the lack of psychiatric history, and the non-responding to psychopharmacological treatment. Early diagnosis and treatment is essential for recovery and may improve the prognosis. SN - 2295-3337 UR - https://www.unboundmedicine.com/medline/citation/29050531/Anti_NMDA_receptor_encephalitis:_still_unknown_and_underdiagnosed_by_physicians_and_especially_by_psychiatrists L2 - http://www.tandfonline.com/doi/full/10.1080/17843286.2017.1392077 DB - PRIME DP - Unbound Medicine ER -