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Preparation and investigation of novel gastro-floating tablets with 3D extrusion-based printing.
Int J Pharm. 2018 Jan 15; 535(1-2):325-332.IJ

Abstract

Three dimensional (3D) extrusion-based printing is a paste-based rapid prototyping process, which is capable of building complex 3D structures. The aim of this study was to explore the feasibility of 3D extrusion-based printing as a pharmaceutical manufacture technique for the fabrication of gastro-floating tablets. Novel low-density lattice internal structure gastro-floating tablets of dipyridamole were developed to prolong the gastric residence time in order to improve drug release rate and consequently, improve bioavailability and therapeutic efficacy. Excipients commonly employed in the pharmaceutical study could be efficiently applied in the room temperature 3D extrusion-based printing process. The tablets were designed with three kinds of infill percentage and prepared by hydroxypropyl methylcellulose (HPMC K4M) and hydroxypropyl methylcellulose (HPMC E15) as hydrophilic matrices and microcrystalline cellulose (MCC PH101) as extrusion molding agent. In vitro evaluation of the 3D printed gastro-floating tablets was performed by determining mechanical properties, content uniformity, and weight variation. Furthermore, re-floating ability, floating duration time, and drug release behavior were also evaluated. Dissolution profiles revealed the relationship between infill percentage and drug release behavior. The results of this study revealed the potential of 3D extrusion-based printing to fabricate gastro-floating tablets with more than 8h floating process with traditional pharmaceutical excipients and lattice internal structure design.

Authors+Show Affiliations

Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.Discipline Construction and Development Planning Section, Shenyang Medical College, 146 Huanghe North Street, Shenyang 110034, China.Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.Department of Pharmaceutical Information, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, 110016, China.Shanghai Jingxin Biology & Pharmaceutical Co., Ltd., 150 Copernicus Road, Zhangjiang High Technology Park, Shanghai, 201210, China.Shanghai Jingxin Biology & Pharmaceutical Co., Ltd., 150 Copernicus Road, Zhangjiang High Technology Park, Shanghai, 201210, China.Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China. Electronic address: yangxg123@163.com.Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China. Electronic address: pppwwwsss@163.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29051121

Citation

Li, Qijun, et al. "Preparation and Investigation of Novel Gastro-floating Tablets With 3D Extrusion-based Printing." International Journal of Pharmaceutics, vol. 535, no. 1-2, 2018, pp. 325-332.
Li Q, Guan X, Cui M, et al. Preparation and investigation of novel gastro-floating tablets with 3D extrusion-based printing. Int J Pharm. 2018;535(1-2):325-332.
Li, Q., Guan, X., Cui, M., Zhu, Z., Chen, K., Wen, H., Jia, D., Hou, J., Xu, W., Yang, X., & Pan, W. (2018). Preparation and investigation of novel gastro-floating tablets with 3D extrusion-based printing. International Journal of Pharmaceutics, 535(1-2), 325-332. https://doi.org/10.1016/j.ijpharm.2017.10.037
Li Q, et al. Preparation and Investigation of Novel Gastro-floating Tablets With 3D Extrusion-based Printing. Int J Pharm. 2018 Jan 15;535(1-2):325-332. PubMed PMID: 29051121.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation and investigation of novel gastro-floating tablets with 3D extrusion-based printing. AU - Li,Qijun, AU - Guan,Xiaoying, AU - Cui,Mengsuo, AU - Zhu,Zhihong, AU - Chen,Kai, AU - Wen,Haoyang, AU - Jia,Danyang, AU - Hou,Jian, AU - Xu,Wenting, AU - Yang,Xinggang, AU - Pan,Weisan, Y1 - 2017/10/16/ PY - 2017/03/31/received PY - 2017/09/24/revised PY - 2017/10/15/accepted PY - 2017/10/21/pubmed PY - 2018/8/30/medline PY - 2017/10/21/entrez KW - 3D printing KW - Gastro-floating KW - Lattice structure KW - Personalized medicine KW - Sustained release SP - 325 EP - 332 JF - International journal of pharmaceutics JO - Int J Pharm VL - 535 IS - 1-2 N2 - Three dimensional (3D) extrusion-based printing is a paste-based rapid prototyping process, which is capable of building complex 3D structures. The aim of this study was to explore the feasibility of 3D extrusion-based printing as a pharmaceutical manufacture technique for the fabrication of gastro-floating tablets. Novel low-density lattice internal structure gastro-floating tablets of dipyridamole were developed to prolong the gastric residence time in order to improve drug release rate and consequently, improve bioavailability and therapeutic efficacy. Excipients commonly employed in the pharmaceutical study could be efficiently applied in the room temperature 3D extrusion-based printing process. The tablets were designed with three kinds of infill percentage and prepared by hydroxypropyl methylcellulose (HPMC K4M) and hydroxypropyl methylcellulose (HPMC E15) as hydrophilic matrices and microcrystalline cellulose (MCC PH101) as extrusion molding agent. In vitro evaluation of the 3D printed gastro-floating tablets was performed by determining mechanical properties, content uniformity, and weight variation. Furthermore, re-floating ability, floating duration time, and drug release behavior were also evaluated. Dissolution profiles revealed the relationship between infill percentage and drug release behavior. The results of this study revealed the potential of 3D extrusion-based printing to fabricate gastro-floating tablets with more than 8h floating process with traditional pharmaceutical excipients and lattice internal structure design. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/29051121/Preparation_and_investigation_of_novel_gastro_floating_tablets_with_3D_extrusion_based_printing_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(17)31016-5 DB - PRIME DP - Unbound Medicine ER -