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What is the role of Staphylococcus aureus and herpes virus infections in the pathogenesis of atopic dermatitis?

Abstract

Atopic dermatitis (AD) is a chronic, relapsing disease. Genetic, environmental and immunological factors are involved in its pathophysiology. Individuals with AD have an increased predisposition to colonization and/or infection of the skin by various pathogens, especially Staphylococcus aureus and herpes simplex virus. The composition of their skin microbiome is also different, and changes during flares. The disease severity can be related to the degree of colonization by S. aureus. In addition, the presence of this bacterial species can predispose the host to more severe and disseminated viral infections. This article reviews the role of S. aureus and herpes virus infections and the skin microbiome in the pathogenesis of AD and their importance in the treatment and prevention strategies of this dermatosis.

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  • Authors+Show Affiliations

    ,

    Pediatric Dermatology Service, IPPMG-Martagão Gesteira Pediatric Institute-Federal University of Rio de Janeiro-UFRJ, Rio de Janeiro, Brazil.

    ,

    Pediatric Dermatology Service, IPPMG-Martagão Gesteira Pediatric Institute-Federal University of Rio de Janeiro-UFRJ, Rio de Janeiro, Brazil.

    ,

    Dentistry Graduate Program, School of Dentistry, Veiga de Almeida University, Rio de Janeiro, Brazil. Post graduation Program in Dentistry, School of Dentistry, Estácio de Sá University, Rio de Janeiro, Brazil.

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    Dentistry Graduate Program, School of Dentistry, Veiga de Almeida University, Rio de Janeiro, Brazil.

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    Microbiology Department-Federal University of Rio de Janeiro-UFRJ, Campus Macaé, Rio de Janeiro, Brazil.

    ,

    Post graduation Program in Dentistry, School of Dentistry, Estácio de Sá University, Rio de Janeiro, Brazil.

    ,

    Post graduation Program in Dentistry, School of Dentistry, Estácio de Sá University, Rio de Janeiro, Brazil.

    Paulo de Goes Microbiology Institute, Federal University Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

    Source

    Future microbiology 12: 2017 11 pg 1327-1334

    MeSH

    Adaptive Immunity
    Chronic Disease
    Dermatitis, Atopic
    Herpesviridae Infections
    Humans
    Immunity, Innate
    Microbiota
    Simplexvirus
    Skin
    Staphylococcal Skin Infections
    Staphylococcus aureus

    Pub Type(s)

    Journal Article
    Review
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    29052452

    Citation

    Saintive, Simone, et al. "What Is the Role of Staphylococcus Aureus and Herpes Virus Infections in the Pathogenesis of Atopic Dermatitis?" Future Microbiology, vol. 12, 2017, pp. 1327-1334.
    Saintive S, Abad E, C Ferreira D, et al. What is the role of Staphylococcus aureus and herpes virus infections in the pathogenesis of atopic dermatitis? Future Microbiol. 2017;12:1327-1334.
    Saintive, S., Abad, E., C Ferreira, D., Stambovsky, M., Cavalcante, F. S., Gonçalves, L. S., ... Dos Santos, K. R. (2017). What is the role of Staphylococcus aureus and herpes virus infections in the pathogenesis of atopic dermatitis? Future Microbiology, 12, pp. 1327-1334. doi:10.2217/fmb-2017-0081.
    Saintive S, et al. What Is the Role of Staphylococcus Aureus and Herpes Virus Infections in the Pathogenesis of Atopic Dermatitis. Future Microbiol. 2017;12:1327-1334. PubMed PMID: 29052452.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - What is the role of Staphylococcus aureus and herpes virus infections in the pathogenesis of atopic dermatitis? AU - Saintive,Simone, AU - Abad,Eliane, AU - C Ferreira,Dennis de, AU - Stambovsky,Mayra, AU - Cavalcante,Fernanda S, AU - Gonçalves,Lucio S, AU - Vidal,Fabio, AU - Dos Santos,Katia Rn, Y1 - 2017/10/20/ PY - 2017/10/21/pubmed PY - 2018/7/22/medline PY - 2017/10/21/entrez KW - Staphylococcus aureus KW - atopic dermatitis KW - herpes simplex virus KW - microbiome SP - 1327 EP - 1334 JF - Future microbiology JO - Future Microbiol VL - 12 N2 - Atopic dermatitis (AD) is a chronic, relapsing disease. Genetic, environmental and immunological factors are involved in its pathophysiology. Individuals with AD have an increased predisposition to colonization and/or infection of the skin by various pathogens, especially Staphylococcus aureus and herpes simplex virus. The composition of their skin microbiome is also different, and changes during flares. The disease severity can be related to the degree of colonization by S. aureus. In addition, the presence of this bacterial species can predispose the host to more severe and disseminated viral infections. This article reviews the role of S. aureus and herpes virus infections and the skin microbiome in the pathogenesis of AD and their importance in the treatment and prevention strategies of this dermatosis. SN - 1746-0921 UR - https://www.unboundmedicine.com/medline/citation/29052452/What_is_the_role_of_Staphylococcus_aureus_and_herpes_virus_infections_in_the_pathogenesis_of_atopic_dermatitis L2 - http://www.futuremedicine.com/doi/full/10.2217/fmb-2017-0081?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -