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What is the role of Staphylococcus aureus and herpes virus infections in the pathogenesis of atopic dermatitis?
Future Microbiol 2017; 12:1327-1334FM

Abstract

Atopic dermatitis (AD) is a chronic, relapsing disease. Genetic, environmental and immunological factors are involved in its pathophysiology. Individuals with AD have an increased predisposition to colonization and/or infection of the skin by various pathogens, especially Staphylococcus aureus and herpes simplex virus. The composition of their skin microbiome is also different, and changes during flares. The disease severity can be related to the degree of colonization by S. aureus. In addition, the presence of this bacterial species can predispose the host to more severe and disseminated viral infections. This article reviews the role of S. aureus and herpes virus infections and the skin microbiome in the pathogenesis of AD and their importance in the treatment and prevention strategies of this dermatosis.

Authors+Show Affiliations

Pediatric Dermatology Service, IPPMG-Martagão Gesteira Pediatric Institute-Federal University of Rio de Janeiro-UFRJ, Rio de Janeiro, Brazil.Pediatric Dermatology Service, IPPMG-Martagão Gesteira Pediatric Institute-Federal University of Rio de Janeiro-UFRJ, Rio de Janeiro, Brazil.Dentistry Graduate Program, School of Dentistry, Veiga de Almeida University, Rio de Janeiro, Brazil. Post graduation Program in Dentistry, School of Dentistry, Estácio de Sá University, Rio de Janeiro, Brazil.Dentistry Graduate Program, School of Dentistry, Veiga de Almeida University, Rio de Janeiro, Brazil.Microbiology Department-Federal University of Rio de Janeiro-UFRJ, Campus Macaé, Rio de Janeiro, Brazil.Post graduation Program in Dentistry, School of Dentistry, Estácio de Sá University, Rio de Janeiro, Brazil.Post graduation Program in Dentistry, School of Dentistry, Estácio de Sá University, Rio de Janeiro, Brazil.Paulo de Goes Microbiology Institute, Federal University Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29052452

Citation

Saintive, Simone, et al. "What Is the Role of Staphylococcus Aureus and Herpes Virus Infections in the Pathogenesis of Atopic Dermatitis?" Future Microbiology, vol. 12, 2017, pp. 1327-1334.
Saintive S, Abad E, C Ferreira D, et al. What is the role of Staphylococcus aureus and herpes virus infections in the pathogenesis of atopic dermatitis? Future Microbiol. 2017;12:1327-1334.
Saintive, S., Abad, E., C Ferreira, D., Stambovsky, M., Cavalcante, F. S., Gonçalves, L. S., ... Dos Santos, K. R. (2017). What is the role of Staphylococcus aureus and herpes virus infections in the pathogenesis of atopic dermatitis? Future Microbiology, 12, pp. 1327-1334. doi:10.2217/fmb-2017-0081.
Saintive S, et al. What Is the Role of Staphylococcus Aureus and Herpes Virus Infections in the Pathogenesis of Atopic Dermatitis. Future Microbiol. 2017;12:1327-1334. PubMed PMID: 29052452.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - What is the role of Staphylococcus aureus and herpes virus infections in the pathogenesis of atopic dermatitis? AU - Saintive,Simone, AU - Abad,Eliane, AU - C Ferreira,Dennis de, AU - Stambovsky,Mayra, AU - Cavalcante,Fernanda S, AU - Gonçalves,Lucio S, AU - Vidal,Fabio, AU - Dos Santos,Katia Rn, Y1 - 2017/10/20/ PY - 2017/10/21/pubmed PY - 2018/7/22/medline PY - 2017/10/21/entrez KW - Staphylococcus aureus KW - atopic dermatitis KW - herpes simplex virus KW - microbiome SP - 1327 EP - 1334 JF - Future microbiology JO - Future Microbiol VL - 12 N2 - Atopic dermatitis (AD) is a chronic, relapsing disease. Genetic, environmental and immunological factors are involved in its pathophysiology. Individuals with AD have an increased predisposition to colonization and/or infection of the skin by various pathogens, especially Staphylococcus aureus and herpes simplex virus. The composition of their skin microbiome is also different, and changes during flares. The disease severity can be related to the degree of colonization by S. aureus. In addition, the presence of this bacterial species can predispose the host to more severe and disseminated viral infections. This article reviews the role of S. aureus and herpes virus infections and the skin microbiome in the pathogenesis of AD and their importance in the treatment and prevention strategies of this dermatosis. SN - 1746-0921 UR - https://www.unboundmedicine.com/medline/citation/29052452/What_is_the_role_of_Staphylococcus_aureus_and_herpes_virus_infections_in_the_pathogenesis_of_atopic_dermatitis L2 - http://www.futuremedicine.com/doi/full/10.2217/fmb-2017-0081?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -