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Lesions of the lateral habenula improve working memory performance in hemiparkinsonian rats.
Neurosci Lett 2018; 662:162-166NL

Abstract

The lateral habenula (LHb) is an important structure involved in various brain functions, because it controls the activity of dopaminergic and serotonergic systems in the midbrain. The impairment of working memory commonly occurs in Parkinson's disease; however, it is not clear whether the LHb involves in the regulation of working memory in rats with unilateral 6-hydroxydopamine lesions of the medial forebrain bundle (MFB). In this study, we found that the MFB lesions in rats decreased choice accuracy as measured by the T-maze rewarded alternation test compared to control rats, indicating the induction of working memory impairment, and decreased dopamine (DA) levels in the medial prefrontal cortex (mPFC), hippocampus and amygdala. Further, rats in the MFB and LHb lesion group showed increased choice accuracy compared to rats in the MFB lesion group, indicating the enhancement of working memory after lesioning the LHb. Neurochemical results found that lesions of the LHb increased DA levels in the mPFC, hippocampus and amygdala in the MFB and LHb lesion group, as well as serotonin (5-HT) level in the mPFC. These findings suggest that DA depletion plays a key role in working memory impairment, and lesions of the LHb improve working memory in the MFB-lesioned rats, which involves in increases in the levels of DA and 5-HT in the mPFC, hippocampus and amygdala. Additionally, the present results may have implications for improving our understanding of the neuropathology and/or treatment of PD.

Authors+Show Affiliations

Department of Rehabilitation Medicine, The Second Hospital, Xi'an Jiaotong University, Xi'an 710004, China.Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.Department of Rehabilitation Medicine, The Second Hospital, Xi'an Jiaotong University, Xi'an 710004, China. Electronic address: zhangqj@mail.xjtu.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29054431

Citation

Du, Cheng Xue, et al. "Lesions of the Lateral Habenula Improve Working Memory Performance in Hemiparkinsonian Rats." Neuroscience Letters, vol. 662, 2018, pp. 162-166.
Du CX, Liu J, Guo Y, et al. Lesions of the lateral habenula improve working memory performance in hemiparkinsonian rats. Neurosci Lett. 2018;662:162-166.
Du, C. X., Liu, J., Guo, Y., Zhang, L., & Zhang, Q. J. (2018). Lesions of the lateral habenula improve working memory performance in hemiparkinsonian rats. Neuroscience Letters, 662, pp. 162-166. doi:10.1016/j.neulet.2017.10.027.
Du CX, et al. Lesions of the Lateral Habenula Improve Working Memory Performance in Hemiparkinsonian Rats. Neurosci Lett. 2018 Jan 1;662:162-166. PubMed PMID: 29054431.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lesions of the lateral habenula improve working memory performance in hemiparkinsonian rats. AU - Du,Cheng Xue, AU - Liu,Jian, AU - Guo,Yuan, AU - Zhang,Li, AU - Zhang,Qiao Jun, Y1 - 2017/10/17/ PY - 2017/06/21/received PY - 2017/10/15/revised PY - 2017/10/16/accepted PY - 2017/10/22/pubmed PY - 2018/6/30/medline PY - 2017/10/22/entrez KW - 5-HT KW - DA KW - Lateral habenula KW - Parkinson’s disease KW - Rat KW - Working memory SP - 162 EP - 166 JF - Neuroscience letters JO - Neurosci. Lett. VL - 662 N2 - The lateral habenula (LHb) is an important structure involved in various brain functions, because it controls the activity of dopaminergic and serotonergic systems in the midbrain. The impairment of working memory commonly occurs in Parkinson's disease; however, it is not clear whether the LHb involves in the regulation of working memory in rats with unilateral 6-hydroxydopamine lesions of the medial forebrain bundle (MFB). In this study, we found that the MFB lesions in rats decreased choice accuracy as measured by the T-maze rewarded alternation test compared to control rats, indicating the induction of working memory impairment, and decreased dopamine (DA) levels in the medial prefrontal cortex (mPFC), hippocampus and amygdala. Further, rats in the MFB and LHb lesion group showed increased choice accuracy compared to rats in the MFB lesion group, indicating the enhancement of working memory after lesioning the LHb. Neurochemical results found that lesions of the LHb increased DA levels in the mPFC, hippocampus and amygdala in the MFB and LHb lesion group, as well as serotonin (5-HT) level in the mPFC. These findings suggest that DA depletion plays a key role in working memory impairment, and lesions of the LHb improve working memory in the MFB-lesioned rats, which involves in increases in the levels of DA and 5-HT in the mPFC, hippocampus and amygdala. Additionally, the present results may have implications for improving our understanding of the neuropathology and/or treatment of PD. SN - 1872-7972 UR - https://www.unboundmedicine.com/medline/citation/29054431/Lesions_of_the_lateral_habenula_improve_working_memory_performance_in_hemiparkinsonian_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(17)30845-5 DB - PRIME DP - Unbound Medicine ER -