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Decreasing body mass index is associated with cerebrospinal fluid markers of Alzheimer's pathology in MCI and mild dementia.
Exp Gerontol. 2017 12 15; 100:45-53.EG

Abstract

BACKGROUND

Several studies have identified an association between body mass index (BMI) and the incidence and severity of Alzheimer's disease (AD) but this relationship is not fully understood.

OBJECTIVE

The primary objective of this study was to assess the possible association between BMI and cerebrospinal fluid (CSF) biomarkers of AD pathology in subjects with normal cognition and cognitive impairment. The secondary objective was to test whether BMI may contribute to improve the accuracy of a clinical model to predict AD pathology in memory clinic patients with cognitive impairment.

METHOD

One hundred and seven elderly subjects with cognitive impairment (91 memory clinic patients with mild cognitive impairment [MCI] and 16 with dementia of AD type) and 55 cognitively healthy volunteers were included in this study. All subjects received a comprehensive clinical and neuropsychological evaluation and a lumbar puncture for CSF biomarker analysis. Multiple linear regressions and receiver operating characteristic (ROC) analyses were carried out to assess the association between BMI and the CSF biomarkers of AD pathology.

RESULTS

BMI was positively correlated with the CSF levels of Aβ42 and negatively with tau and P-tau181 in participants with cognitive impairment. The associations were independent of age, sex, educational level, type and severity of cognitive impairment, cerebrovascular risk factors and the presence of the APOEε4 allele. Furthermore, BMI significantly improved the sensitivity and specificity of a multi-factorial model to predict the presence of an AD CSF biomarker profile.

CONCLUSION

Lower BMI is associated with cerebral AD pathology rather than with cognitive impairment in elderly subjects with MCI and mild dementia. Along with other clinical factors, decreasing BMI may help the clinician to identify patients with cognitive impairment due to AD.

Authors+Show Affiliations

Old Age Psychiatry, Department of Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland.Departement of Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland.Departement of Laboratory Medicine, University Hospital of Lausanne, Lausanne, Switzerland.Old Age Psychiatry, Department of Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland.Old Age Psychiatry, Department of Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland; Geriatric Psychiatry, Geneva University Hospitals and University of Geneva, Switzerland. Electronic address: julius.popp@chuv.ch.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29054536

Citation

Mathys, Jules, et al. "Decreasing Body Mass Index Is Associated With Cerebrospinal Fluid Markers of Alzheimer's Pathology in MCI and Mild Dementia." Experimental Gerontology, vol. 100, 2017, pp. 45-53.
Mathys J, Gholamrezaee M, Henry H, et al. Decreasing body mass index is associated with cerebrospinal fluid markers of Alzheimer's pathology in MCI and mild dementia. Exp Gerontol. 2017;100:45-53.
Mathys, J., Gholamrezaee, M., Henry, H., von Gunten, A., & Popp, J. (2017). Decreasing body mass index is associated with cerebrospinal fluid markers of Alzheimer's pathology in MCI and mild dementia. Experimental Gerontology, 100, 45-53. https://doi.org/10.1016/j.exger.2017.10.013
Mathys J, et al. Decreasing Body Mass Index Is Associated With Cerebrospinal Fluid Markers of Alzheimer's Pathology in MCI and Mild Dementia. Exp Gerontol. 2017 12 15;100:45-53. PubMed PMID: 29054536.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decreasing body mass index is associated with cerebrospinal fluid markers of Alzheimer's pathology in MCI and mild dementia. AU - Mathys,Jules, AU - Gholamrezaee,Mehdi, AU - Henry,Hugues, AU - von Gunten,Armin, AU - Popp,Julius, Y1 - 2017/10/17/ PY - 2017/06/12/received PY - 2017/09/19/revised PY - 2017/10/16/accepted PY - 2017/10/22/pubmed PY - 2018/7/24/medline PY - 2017/10/22/entrez KW - Alzheimer's disease KW - Body mass index KW - Cerebrospinal fluid biomarkers KW - Dementia KW - Mild cognitive impairment KW - Weight loss SP - 45 EP - 53 JF - Experimental gerontology JO - Exp Gerontol VL - 100 N2 - BACKGROUND: Several studies have identified an association between body mass index (BMI) and the incidence and severity of Alzheimer's disease (AD) but this relationship is not fully understood. OBJECTIVE: The primary objective of this study was to assess the possible association between BMI and cerebrospinal fluid (CSF) biomarkers of AD pathology in subjects with normal cognition and cognitive impairment. The secondary objective was to test whether BMI may contribute to improve the accuracy of a clinical model to predict AD pathology in memory clinic patients with cognitive impairment. METHOD: One hundred and seven elderly subjects with cognitive impairment (91 memory clinic patients with mild cognitive impairment [MCI] and 16 with dementia of AD type) and 55 cognitively healthy volunteers were included in this study. All subjects received a comprehensive clinical and neuropsychological evaluation and a lumbar puncture for CSF biomarker analysis. Multiple linear regressions and receiver operating characteristic (ROC) analyses were carried out to assess the association between BMI and the CSF biomarkers of AD pathology. RESULTS: BMI was positively correlated with the CSF levels of Aβ42 and negatively with tau and P-tau181 in participants with cognitive impairment. The associations were independent of age, sex, educational level, type and severity of cognitive impairment, cerebrovascular risk factors and the presence of the APOEε4 allele. Furthermore, BMI significantly improved the sensitivity and specificity of a multi-factorial model to predict the presence of an AD CSF biomarker profile. CONCLUSION: Lower BMI is associated with cerebral AD pathology rather than with cognitive impairment in elderly subjects with MCI and mild dementia. Along with other clinical factors, decreasing BMI may help the clinician to identify patients with cognitive impairment due to AD. SN - 1873-6815 UR - https://www.unboundmedicine.com/medline/citation/29054536/Decreasing_body_mass_index_is_associated_with_cerebrospinal_fluid_markers_of_Alzheimer's_pathology_in_MCI_and_mild_dementia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0531-5565(17)30465-5 DB - PRIME DP - Unbound Medicine ER -