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Magnesium as a new player in CKD: too little is as bad as too much?
Kidney Int. 2017 11; 92(5):1034-1036.KI

Abstract

Vascular calcification is a serious complication of chronic kidney disease, but the current therapeutic strategy is insufficient for preventing its progression. Magnesium is a potent inhibitor of calcification and represents a promising therapeutic candidate. Diaz-Tocados and colleagues now demonstrate that magnesium supplementation prevents the progression of vascular calcification in a uremic rat model, independently of the phosphate-binding capacity. We should keep in mind, however, that too much magnesium could have adverse effects on bone metabolism.

Authors+Show Affiliations

Division of Nephrology, Endocrinology and Metabolism, Tokai University School of Medicine, Isehara, Japan.Division of Nephrology, Endocrinology and Metabolism, Tokai University School of Medicine, Isehara, Japan; The Institute of Medical Sciences, Tokai University, Isehara, Japan.Division of Nephrology, Endocrinology and Metabolism, Tokai University School of Medicine, Isehara, Japan. Electronic address: fukagawa@tokai-u.jp.

Pub Type(s)

Journal Article
Comment

Language

eng

PubMed ID

29055421

Citation

Hamano, Naoto, et al. "Magnesium as a New Player in CKD: Too Little Is as Bad as Too Much?" Kidney International, vol. 92, no. 5, 2017, pp. 1034-1036.
Hamano N, Komaba H, Fukagawa M. Magnesium as a new player in CKD: too little is as bad as too much? Kidney Int. 2017;92(5):1034-1036.
Hamano, N., Komaba, H., & Fukagawa, M. (2017). Magnesium as a new player in CKD: too little is as bad as too much? Kidney International, 92(5), 1034-1036. https://doi.org/10.1016/j.kint.2017.05.032
Hamano N, Komaba H, Fukagawa M. Magnesium as a New Player in CKD: Too Little Is as Bad as Too Much. Kidney Int. 2017;92(5):1034-1036. PubMed PMID: 29055421.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Magnesium as a new player in CKD: too little is as bad as too much? AU - Hamano,Naoto, AU - Komaba,Hirotaka, AU - Fukagawa,Masafumi, PY - 2017/05/01/received PY - 2017/05/05/revised PY - 2017/05/10/accepted PY - 2017/10/23/entrez PY - 2017/10/23/pubmed PY - 2018/7/17/medline SP - 1034 EP - 1036 JF - Kidney international JO - Kidney Int VL - 92 IS - 5 N2 - Vascular calcification is a serious complication of chronic kidney disease, but the current therapeutic strategy is insufficient for preventing its progression. Magnesium is a potent inhibitor of calcification and represents a promising therapeutic candidate. Diaz-Tocados and colleagues now demonstrate that magnesium supplementation prevents the progression of vascular calcification in a uremic rat model, independently of the phosphate-binding capacity. We should keep in mind, however, that too much magnesium could have adverse effects on bone metabolism. SN - 1523-1755 UR - https://www.unboundmedicine.com/medline/citation/29055421/Magnesium_as_a_new_player_in_CKD:_too_little_is_as_bad_as_too_much L2 - https://linkinghub.elsevier.com/retrieve/pii/S0085-2538(17)30460-X DB - PRIME DP - Unbound Medicine ER -