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A case of MOG antibody-positive bilateral optic neuritis and meningoganglionitis following a genital herpes simplex virus infection.
Mult Scler Relat Disord. 2017 Oct; 17:148-150.MS

Abstract

BACKGROUND

Myelin oligodendrocyte glycoprotein (MOG) antibody-positive optic neuritis (ON) and myelitis are recognized as important differential diagnosis of aquaporin-4 (AQP4) antibody-positive neuromyelitis optica (NMO)/NMO spectrum disorder (NMOSD). Similar to NMO/NMOSD associated with AQP4 antibodies, preceding infections have been reported in patients with MOG antibody-positive ON. This is the first report of bilateral ON following a herpes simplex virus (HSV) infection associated with a positive MOG antibody.

CASE PRESENTATION

A 41-year-old man who initially presented with genital herpes developed allodynia in the Th2-Th5 and Th8-L2 areas, urinary retention, and painful visual loss in the left eye. Ophthalmological evaluation and brain magnetic resonance imaging (MRI) revealed bilateral ON. A spinal MRI showed leptomeningeal enhancement from the thoracic to lumbar vertebrae and abnormal enhancement of the L3 to S3 dorsal root ganglia without a change in intramedullary signals. Following treatment with acyclovir and steroid pulse, he fully recovered. Serum anti-AQP4 antibodies were negative, but anti-MOG antibodies were positive. Finally, he was diagnosed with MOG antibody-positive bilateral ON and meningoganglionitis following an HSV infection.

CONCLUSION

Our case supports a relationship between anti-MOG antibodies and ON triggered by an HSV infection. Clinicians should thus consider testing for MOG antibodies in patients with post-infectious neurological symptoms due to an HSV infection.

Authors+Show Affiliations

Department of Neurology, Kansai Medical University, 2-5-1, Shinmachi, Hirakata, Osaka 5731010, Japan. Electronic address: nakamuma@hirakata.kmu.ac.jp.Department of Neurology, Kansai Medical University, 2-5-1, Shinmachi, Hirakata, Osaka 5731010, Japan.Department of Neurology, Tohoku University Graduate School of Medicine, 1-1, Seiryo-cho, Aoba-ku, Sendai 9808574, Japan; Department of Neurology, Yonezawa National Hospital, 26100-1, Misawa, Yonezawa 9921202, Japan.Department of Neurology, Tohoku University Graduate School of Medicine, 1-1, Seiryo-cho, Aoba-ku, Sendai 9808574, Japan.Department of Neurology, Tohoku University Graduate School of Medicine, 1-1, Seiryo-cho, Aoba-ku, Sendai 9808574, Japan.Department of Neurology, Kansai Medical University, 2-5-1, Shinmachi, Hirakata, Osaka 5731010, Japan.Department of Neurology, Kansai Medical University, 2-5-1, Shinmachi, Hirakata, Osaka 5731010, Japan.Department of Neurology, Kansai Medical University, 2-5-1, Shinmachi, Hirakata, Osaka 5731010, Japan.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

29055448

Citation

Nakamura, Masataka, et al. "A Case of MOG Antibody-positive Bilateral Optic Neuritis and Meningoganglionitis Following a Genital Herpes Simplex Virus Infection." Multiple Sclerosis and Related Disorders, vol. 17, 2017, pp. 148-150.
Nakamura M, Iwasaki Y, Takahashi T, et al. A case of MOG antibody-positive bilateral optic neuritis and meningoganglionitis following a genital herpes simplex virus infection. Mult Scler Relat Disord. 2017;17:148-150.
Nakamura, M., Iwasaki, Y., Takahashi, T., Kaneko, K., Nakashima, I., Kunieda, T., Kaneko, S., & Kusaka, H. (2017). A case of MOG antibody-positive bilateral optic neuritis and meningoganglionitis following a genital herpes simplex virus infection. Multiple Sclerosis and Related Disorders, 17, 148-150. https://doi.org/10.1016/j.msard.2017.07.023
Nakamura M, et al. A Case of MOG Antibody-positive Bilateral Optic Neuritis and Meningoganglionitis Following a Genital Herpes Simplex Virus Infection. Mult Scler Relat Disord. 2017;17:148-150. PubMed PMID: 29055448.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A case of MOG antibody-positive bilateral optic neuritis and meningoganglionitis following a genital herpes simplex virus infection. AU - Nakamura,Masataka, AU - Iwasaki,Yuko, AU - Takahashi,Toshiyuki, AU - Kaneko,Kimihiko, AU - Nakashima,Ichiro, AU - Kunieda,Takenobu, AU - Kaneko,Satoshi, AU - Kusaka,Hirofumi, Y1 - 2017/07/27/ PY - 2017/04/17/received PY - 2017/07/19/revised PY - 2017/07/24/accepted PY - 2017/10/23/entrez PY - 2017/10/23/pubmed PY - 2018/6/8/medline KW - Herpes simplex virus KW - Meningitis KW - Myelin-oligodendrocyte glycoprotein antibody KW - Optic neuritis KW - Urinary retention SP - 148 EP - 150 JF - Multiple sclerosis and related disorders JO - Mult Scler Relat Disord VL - 17 N2 - BACKGROUND: Myelin oligodendrocyte glycoprotein (MOG) antibody-positive optic neuritis (ON) and myelitis are recognized as important differential diagnosis of aquaporin-4 (AQP4) antibody-positive neuromyelitis optica (NMO)/NMO spectrum disorder (NMOSD). Similar to NMO/NMOSD associated with AQP4 antibodies, preceding infections have been reported in patients with MOG antibody-positive ON. This is the first report of bilateral ON following a herpes simplex virus (HSV) infection associated with a positive MOG antibody. CASE PRESENTATION: A 41-year-old man who initially presented with genital herpes developed allodynia in the Th2-Th5 and Th8-L2 areas, urinary retention, and painful visual loss in the left eye. Ophthalmological evaluation and brain magnetic resonance imaging (MRI) revealed bilateral ON. A spinal MRI showed leptomeningeal enhancement from the thoracic to lumbar vertebrae and abnormal enhancement of the L3 to S3 dorsal root ganglia without a change in intramedullary signals. Following treatment with acyclovir and steroid pulse, he fully recovered. Serum anti-AQP4 antibodies were negative, but anti-MOG antibodies were positive. Finally, he was diagnosed with MOG antibody-positive bilateral ON and meningoganglionitis following an HSV infection. CONCLUSION: Our case supports a relationship between anti-MOG antibodies and ON triggered by an HSV infection. Clinicians should thus consider testing for MOG antibodies in patients with post-infectious neurological symptoms due to an HSV infection. SN - 2211-0356 UR - https://www.unboundmedicine.com/medline/citation/29055448/A_case_of_MOG_antibody_positive_bilateral_optic_neuritis_and_meningoganglionitis_following_a_genital_herpes_simplex_virus_infection_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2211-0348(17)30183-9 DB - PRIME DP - Unbound Medicine ER -