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Coronary Artery Calcium Progression Is Associated With Coronary Plaque Volume Progression: Results From a Quantitative Semiautomated Coronary Artery Plaque Analysis.
JACC Cardiovasc Imaging. 2018 12; 11(12):1785-1794.JC

Abstract

OBJECTIVES

The aim of this study was to determine whether coronary artery calcium (CAC) progression was associated with coronary plaque progression on coronary computed tomographic angiography.

BACKGROUND

CAC progression and coronary plaque characteristics are associated with incident coronary heart disease. However, natural history of coronary atherosclerosis has not been well described to date, and the understanding of the association between CAC progression and coronary plaque subtypes such as noncalcified plaque progression remains unclear.

METHODS

Consecutive patients who were referred to our clinic for evaluation and had serial coronary computed tomography angiography scans performed were included in the study. Coronary artery plaque (total, fibrous, fibrous-fatty, low-attenuation, densely calcified) volumes were calculated using semiautomated plaque analysis software.

RESULTS

A total of 211 patients (61.3 ± 12.7 years of age, 75.4% men) were included in the analysis. The mean interval between baseline and follow-up scans was 3.3 ± 1.7 years. CAC progression was associated with a significant linear increase in all types of coronary plaque and no plaque progression was observed in subjects without CAC progression. In multivariate analysis, annualized and normalized total plaque (β = 0.38; p < 0.001), noncalcified plaque (β = 0.35; p = 0.001), fibrous plaque (β = 0.56; p < 0.001), and calcified plaque (β = 0.63; p = 0.001) volume progression, but not fibrous-fatty (β = 0.03; p = 0.28) or low-attenuation plaque (β = 0.11; p = 0.1) progression, were independently associated with CAC progression. Plaque progression did not differ between the sexes. A significantly increased total and calcified plaque progression was observed in statin users.

CONCLUSIONS

In a clinical practice setting, progression of CAC was significantly associated with an increase in both calcified and noncalcified plaque volume, except fibrous-fatty and low-attenuation plaque. Serial CAC measurements may be helpful in determining the need for intensification of preventive treatment.

Authors+Show Affiliations

Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California; Departments of Cardiology and Radiology, Academy of Medicine, Lithuanian University of Health Sciences, Kaunas, Lithuania.Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California. Electronic address: rnakanishi@labiomed.org.Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California.Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California.Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California.Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California.Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California.Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California.Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California.Division of Image Processing, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.Division of Image Processing, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands; Medis Medical Imaging Systems, Leiden, the Netherlands.Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

29055625

Citation

Ceponiene, Indre, et al. "Coronary Artery Calcium Progression Is Associated With Coronary Plaque Volume Progression: Results From a Quantitative Semiautomated Coronary Artery Plaque Analysis." JACC. Cardiovascular Imaging, vol. 11, no. 12, 2018, pp. 1785-1794.
Ceponiene I, Nakanishi R, Osawa K, et al. Coronary Artery Calcium Progression Is Associated With Coronary Plaque Volume Progression: Results From a Quantitative Semiautomated Coronary Artery Plaque Analysis. JACC Cardiovasc Imaging. 2018;11(12):1785-1794.
Ceponiene, I., Nakanishi, R., Osawa, K., Kanisawa, M., Nezarat, N., Rahmani, S., Kissel, K., Kim, M., Jayawardena, E., Broersen, A., Kitslaar, P., & Budoff, M. J. (2018). Coronary Artery Calcium Progression Is Associated With Coronary Plaque Volume Progression: Results From a Quantitative Semiautomated Coronary Artery Plaque Analysis. JACC. Cardiovascular Imaging, 11(12), 1785-1794. https://doi.org/10.1016/j.jcmg.2017.07.023
Ceponiene I, et al. Coronary Artery Calcium Progression Is Associated With Coronary Plaque Volume Progression: Results From a Quantitative Semiautomated Coronary Artery Plaque Analysis. JACC Cardiovasc Imaging. 2018;11(12):1785-1794. PubMed PMID: 29055625.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coronary Artery Calcium Progression Is Associated With Coronary Plaque Volume Progression: Results From a Quantitative Semiautomated Coronary Artery Plaque Analysis. AU - Ceponiene,Indre, AU - Nakanishi,Rine, AU - Osawa,Kazuhiro, AU - Kanisawa,Mitsuru, AU - Nezarat,Negin, AU - Rahmani,Sina, AU - Kissel,Kendall, AU - Kim,Michael, AU - Jayawardena,Eranthi, AU - Broersen,Alexander, AU - Kitslaar,Pieter, AU - Budoff,Matthew J, Y1 - 2017/10/18/ PY - 2017/05/22/received PY - 2017/07/05/revised PY - 2017/07/21/accepted PY - 2017/10/23/pubmed PY - 2019/11/20/medline PY - 2017/10/23/entrez KW - coronary artery calcium progression KW - coronary computed tomography angiography KW - plaque progression SP - 1785 EP - 1794 JF - JACC. Cardiovascular imaging JO - JACC Cardiovasc Imaging VL - 11 IS - 12 N2 - OBJECTIVES: The aim of this study was to determine whether coronary artery calcium (CAC) progression was associated with coronary plaque progression on coronary computed tomographic angiography. BACKGROUND: CAC progression and coronary plaque characteristics are associated with incident coronary heart disease. However, natural history of coronary atherosclerosis has not been well described to date, and the understanding of the association between CAC progression and coronary plaque subtypes such as noncalcified plaque progression remains unclear. METHODS: Consecutive patients who were referred to our clinic for evaluation and had serial coronary computed tomography angiography scans performed were included in the study. Coronary artery plaque (total, fibrous, fibrous-fatty, low-attenuation, densely calcified) volumes were calculated using semiautomated plaque analysis software. RESULTS: A total of 211 patients (61.3 ± 12.7 years of age, 75.4% men) were included in the analysis. The mean interval between baseline and follow-up scans was 3.3 ± 1.7 years. CAC progression was associated with a significant linear increase in all types of coronary plaque and no plaque progression was observed in subjects without CAC progression. In multivariate analysis, annualized and normalized total plaque (β = 0.38; p < 0.001), noncalcified plaque (β = 0.35; p = 0.001), fibrous plaque (β = 0.56; p < 0.001), and calcified plaque (β = 0.63; p = 0.001) volume progression, but not fibrous-fatty (β = 0.03; p = 0.28) or low-attenuation plaque (β = 0.11; p = 0.1) progression, were independently associated with CAC progression. Plaque progression did not differ between the sexes. A significantly increased total and calcified plaque progression was observed in statin users. CONCLUSIONS: In a clinical practice setting, progression of CAC was significantly associated with an increase in both calcified and noncalcified plaque volume, except fibrous-fatty and low-attenuation plaque. Serial CAC measurements may be helpful in determining the need for intensification of preventive treatment. SN - 1876-7591 UR - https://www.unboundmedicine.com/medline/citation/29055625/Coronary_Artery_Calcium_Progression_Is_Associated_With_Coronary_Plaque_Volume_Progression:_Results_From_a_Quantitative_Semiautomated_Coronary_Artery_Plaque_Analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1936-878X(17)30802-1 DB - PRIME DP - Unbound Medicine ER -