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Antagonism of spontaneous and evoked bursts by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) in the CA3 region of the in vitro hippocampus.
Brain Res. 1988 Nov 22; 474(1):201-3.BR

Abstract

Superfusion of hippocampal slices with 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) antagonized kainate-induced bursts and bursts of unknown origin in the CA3 region. CNQX also increased the latency of and eventually blocked evoked bursts which persist following kainate washout. In contrast, D-(-)-2-amino-7-phosphonoheptanoic acid did not alter burst latency or block bursts unless applied subsequent to CNQX. We conclude that the quisqualate type receptor has a prominent role in burst generation with a smaller contribution from N-methyl-D-aspartate receptors.

Authors+Show Affiliations

INSERM U29, Hôpital de Port-Royal, Paris, France.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2905616

Citation

Neuman, R S., et al. "Antagonism of Spontaneous and Evoked Bursts By 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) in the CA3 Region of the in Vitro Hippocampus." Brain Research, vol. 474, no. 1, 1988, pp. 201-3.
Neuman RS, Ben-Ari Y, Cherubini E. Antagonism of spontaneous and evoked bursts by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) in the CA3 region of the in vitro hippocampus. Brain Res. 1988;474(1):201-3.
Neuman, R. S., Ben-Ari, Y., & Cherubini, E. (1988). Antagonism of spontaneous and evoked bursts by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) in the CA3 region of the in vitro hippocampus. Brain Research, 474(1), 201-3.
Neuman RS, Ben-Ari Y, Cherubini E. Antagonism of Spontaneous and Evoked Bursts By 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) in the CA3 Region of the in Vitro Hippocampus. Brain Res. 1988 Nov 22;474(1):201-3. PubMed PMID: 2905616.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antagonism of spontaneous and evoked bursts by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) in the CA3 region of the in vitro hippocampus. AU - Neuman,R S, AU - Ben-Ari,Y, AU - Cherubini,E, PY - 1988/11/22/pubmed PY - 1988/11/22/medline PY - 1988/11/22/entrez SP - 201 EP - 3 JF - Brain research JO - Brain Res VL - 474 IS - 1 N2 - Superfusion of hippocampal slices with 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) antagonized kainate-induced bursts and bursts of unknown origin in the CA3 region. CNQX also increased the latency of and eventually blocked evoked bursts which persist following kainate washout. In contrast, D-(-)-2-amino-7-phosphonoheptanoic acid did not alter burst latency or block bursts unless applied subsequent to CNQX. We conclude that the quisqualate type receptor has a prominent role in burst generation with a smaller contribution from N-methyl-D-aspartate receptors. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/2905616/Antagonism_of_spontaneous_and_evoked_bursts_by_6_cyano_7_nitroquinoxaline_23_dione__CNQX__in_the_CA3_region_of_the_in_vitro_hippocampus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0006-8993(88)90686-5 DB - PRIME DP - Unbound Medicine ER -