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Effects of pregnancy and short-lasting acute feed restriction on total ghrelin concentration and metabolic parameters in dairy cattle.
Theriogenology 2018; 106:141-148T

Abstract

The aims of this study were: to compare total ghrelin concentration throughout pregnancy between lactating cows and heifers, and to study the response to acute feed restriction in pregnant or non-pregnant heifers. Blood samples were collected each month of pregnancy from cows (n = 5) and heifers (n = 5) and analyzed for total ghrelin concentration. Compared to pre-conception values, ghrelin concentrations tended to be greater during 3rd month of pregnancy in heifers, whereas they were higher in the 7th, 8th and 9th months in lactating cows, but no difference was detected between lactating cows and heifers. In experiment two, pregnant (n = 4) and non-pregnant (n = 4) heifers were fasted for 24 h. Blood samples were collected 0, 4, 8, 12, 16 and 24 h of fasting and were assayed for, insulin, glucose, cortisol, BHBA and NEFA concentrations, and at time points 0, 8, 16 and 24 for total ghrelin determination. Compared to satiety, ghrelin concentrations were higher at 8th, 16th and 24th hour of fasting in pregnant and at 8th hour in non-pregnant animals, but no difference was detected between pregnant and non-pregnant heifers. Pregnant heifers had lower glucose concentrations than non-pregnant ones. Insulin concentrations were reduced at 4 and 8 h of fasting in pregnant heifers, and stayed unaffected in non-pregnant ones. Cortisol concentrations increased after 4th hour and remained elevated throughout the sampling period in pregnant heifers, while they increased at 24th h in non-pregnant animals. Here, we provide evidence that total ghrelin concentrations rise in response to feed restriction. Albeit no group effect was evident, our results imply that a) during the last trimester of pregnancy total ghrelin is secreted in different pattern between lactating cows and heifers, b) pregnant animals are more responsive than non-pregnant ones to hunger induced stress.

Authors+Show Affiliations

Department of Obstetrics & Reproduction, Veterinary Faculty, University of Thessaly, Karditsa Greece.Department of Obstetrics & Reproduction, Veterinary Faculty, University of Thessaly, Karditsa Greece.Department of Nuclear Medicine, Faculty of Medicine, University of Thessaly, Larissa, Greece.Freelance Collaborator, Thessaloniki, Greece.Department of Obstetrics & Gynecology, Faculty of Medicine, University of Thessaly, Larissa, Greece.Department of Medicine, Veterinary Faculty, University of Thessaly, Karditsa, Greece.Department of Obstetrics & Reproduction, Veterinary Faculty, University of Thessaly, Karditsa Greece.Department of Obstetrics & Reproduction, Veterinary Faculty, University of Thessaly, Karditsa Greece. Electronic address: gsamir@vet.uth.gr.

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

29059601

Citation

Chouzouris, Thomas Markos, et al. "Effects of Pregnancy and Short-lasting Acute Feed Restriction On Total Ghrelin Concentration and Metabolic Parameters in Dairy Cattle." Theriogenology, vol. 106, 2018, pp. 141-148.
Chouzouris TM, Dovolou E, Georgoulias P, et al. Effects of pregnancy and short-lasting acute feed restriction on total ghrelin concentration and metabolic parameters in dairy cattle. Theriogenology. 2018;106:141-148.
Chouzouris, T. M., Dovolou, E., Georgoulias, P., Rekkas, A., Dafopoulos, K., Athanasiou, L., ... Amiridis, G. S. (2018). Effects of pregnancy and short-lasting acute feed restriction on total ghrelin concentration and metabolic parameters in dairy cattle. Theriogenology, 106, pp. 141-148. doi:10.1016/j.theriogenology.2017.10.011.
Chouzouris TM, et al. Effects of Pregnancy and Short-lasting Acute Feed Restriction On Total Ghrelin Concentration and Metabolic Parameters in Dairy Cattle. Theriogenology. 2018 Jan 15;106:141-148. PubMed PMID: 29059601.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of pregnancy and short-lasting acute feed restriction on total ghrelin concentration and metabolic parameters in dairy cattle. AU - Chouzouris,Thomas Markos, AU - Dovolou,Eleni, AU - Georgoulias,Panagiotis, AU - Rekkas,Alexandros, AU - Dafopoulos,Konstantinos, AU - Athanasiou,Lambrini, AU - Fthenakis,George C, AU - Amiridis,Georgios S, Y1 - 2017/10/16/ PY - 2017/07/12/received PY - 2017/10/02/revised PY - 2017/10/07/accepted PY - 2017/10/24/pubmed PY - 2018/7/19/medline PY - 2017/10/24/entrez KW - Cattle KW - Cortisol KW - Feed restriction KW - Ghrelin KW - Glucose KW - Insulin SP - 141 EP - 148 JF - Theriogenology JO - Theriogenology VL - 106 N2 - The aims of this study were: to compare total ghrelin concentration throughout pregnancy between lactating cows and heifers, and to study the response to acute feed restriction in pregnant or non-pregnant heifers. Blood samples were collected each month of pregnancy from cows (n = 5) and heifers (n = 5) and analyzed for total ghrelin concentration. Compared to pre-conception values, ghrelin concentrations tended to be greater during 3rd month of pregnancy in heifers, whereas they were higher in the 7th, 8th and 9th months in lactating cows, but no difference was detected between lactating cows and heifers. In experiment two, pregnant (n = 4) and non-pregnant (n = 4) heifers were fasted for 24 h. Blood samples were collected 0, 4, 8, 12, 16 and 24 h of fasting and were assayed for, insulin, glucose, cortisol, BHBA and NEFA concentrations, and at time points 0, 8, 16 and 24 for total ghrelin determination. Compared to satiety, ghrelin concentrations were higher at 8th, 16th and 24th hour of fasting in pregnant and at 8th hour in non-pregnant animals, but no difference was detected between pregnant and non-pregnant heifers. Pregnant heifers had lower glucose concentrations than non-pregnant ones. Insulin concentrations were reduced at 4 and 8 h of fasting in pregnant heifers, and stayed unaffected in non-pregnant ones. Cortisol concentrations increased after 4th hour and remained elevated throughout the sampling period in pregnant heifers, while they increased at 24th h in non-pregnant animals. Here, we provide evidence that total ghrelin concentrations rise in response to feed restriction. Albeit no group effect was evident, our results imply that a) during the last trimester of pregnancy total ghrelin is secreted in different pattern between lactating cows and heifers, b) pregnant animals are more responsive than non-pregnant ones to hunger induced stress. SN - 1879-3231 UR - https://www.unboundmedicine.com/medline/citation/29059601/Effects_of_pregnancy_and_short_lasting_acute_feed_restriction_on_total_ghrelin_concentration_and_metabolic_parameters_in_dairy_cattle_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0093-691X(17)30485-5 DB - PRIME DP - Unbound Medicine ER -