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Haematological indices and haematinic levels after mini gastric bypass: a matched comparison with Roux-en-Y gastric bypass.
Clin Obes 2018; 8(1):43-49CO

Abstract

Many surgeons believe mini gastric bypass (MGB) is more likely to cause micronutrient malabsorption compared to Roux-en-Y gastric bypass (RYGB). Till date, there is no published study evaluating haematological indices and haematinic levels in patients undergoing MGB and comparing these with a matched cohort of RYGB. Two hundred patients who underwent MGB between October 2012 and October 2015 were matched to 200 patients who underwent RYGB for age, sex, body mass index and time of surgery. We then compared haemoglobin, mean corpuscular volume, iron, ferritin, vitamin B12 and folic acid levels preoperatively and at 6 monthly intervals after surgery until 2 years. The percentage total weight loss was significantly higher in the MGB group compared to the RYGB group at all time points. At 2 years, MGB and RYGB both led to an increase in anaemia rates but the difference was only significant for MGB group. Compared to RYGB, MGB patients were more likely to be anaemic at 2 years, although the difference was not significant statistically (16.6% vs. 12.7%; P value = 0.55). There was a trend for lower iron and folate levels in MGB group compared to RYGB group but the difference was statistically significant at some of the time periods only (significantly lower folate at 6 and 12 months and lower iron at 6 months in the MGB group). MGB leads to a significant increase in anaemia rates in a supplemented cohort. There is a trend towards lower iron and folate levels and higher anaemia rates in MGB group in comparison with RYGB. Larger studies with longer follow-up should evaluate results of MGB with a shorter biliopancreatic limb.

Authors+Show Affiliations

Bariatric Unit, Department of General Surgery, Sunderland Royal Hospital, City Hospitals Sunderland NHS Foundation Trust, Sunderland, UK.Bariatric Unit, Department of General Surgery, Sunderland Royal Hospital, City Hospitals Sunderland NHS Foundation Trust, Sunderland, UK.Bariatric Unit, Department of General Surgery, Sunderland Royal Hospital, City Hospitals Sunderland NHS Foundation Trust, Sunderland, UK.Bariatric Unit, Department of General Surgery, Sunderland Royal Hospital, City Hospitals Sunderland NHS Foundation Trust, Sunderland, UK.Bariatric Unit, Department of General Surgery, Sunderland Royal Hospital, City Hospitals Sunderland NHS Foundation Trust, Sunderland, UK.Bariatric Unit, Department of General Surgery, Sunderland Royal Hospital, City Hospitals Sunderland NHS Foundation Trust, Sunderland, UK.Bariatric Unit, Department of General Surgery, Sunderland Royal Hospital, City Hospitals Sunderland NHS Foundation Trust, Sunderland, UK.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

29063708

Citation

Madhok, B M., et al. "Haematological Indices and Haematinic Levels After Mini Gastric Bypass: a Matched Comparison With Roux-en-Y Gastric Bypass." Clinical Obesity, vol. 8, no. 1, 2018, pp. 43-49.
Madhok BM, Mahawar KK, Hadfield JN, et al. Haematological indices and haematinic levels after mini gastric bypass: a matched comparison with Roux-en-Y gastric bypass. Clin Obes. 2018;8(1):43-49.
Madhok, B. M., Mahawar, K. K., Hadfield, J. N., Courtney, M., Stubbing-Moore, A., Koshy, S., & Small, P. K. (2018). Haematological indices and haematinic levels after mini gastric bypass: a matched comparison with Roux-en-Y gastric bypass. Clinical Obesity, 8(1), pp. 43-49. doi:10.1111/cob.12227.
Madhok BM, et al. Haematological Indices and Haematinic Levels After Mini Gastric Bypass: a Matched Comparison With Roux-en-Y Gastric Bypass. Clin Obes. 2018;8(1):43-49. PubMed PMID: 29063708.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Haematological indices and haematinic levels after mini gastric bypass: a matched comparison with Roux-en-Y gastric bypass. AU - Madhok,B M, AU - Mahawar,K K, AU - Hadfield,J N, AU - Courtney,M, AU - Stubbing-Moore,A, AU - Koshy,S, AU - Small,P K, Y1 - 2017/10/23/ PY - 2017/04/04/received PY - 2017/08/01/revised PY - 2017/08/18/accepted PY - 2017/10/25/pubmed PY - 2018/8/28/medline PY - 2017/10/25/entrez KW - Anaemia KW - Roux-en-Y gastric bypass KW - haematinic KW - mini gastric bypass SP - 43 EP - 49 JF - Clinical obesity JO - Clin Obes VL - 8 IS - 1 N2 - Many surgeons believe mini gastric bypass (MGB) is more likely to cause micronutrient malabsorption compared to Roux-en-Y gastric bypass (RYGB). Till date, there is no published study evaluating haematological indices and haematinic levels in patients undergoing MGB and comparing these with a matched cohort of RYGB. Two hundred patients who underwent MGB between October 2012 and October 2015 were matched to 200 patients who underwent RYGB for age, sex, body mass index and time of surgery. We then compared haemoglobin, mean corpuscular volume, iron, ferritin, vitamin B12 and folic acid levels preoperatively and at 6 monthly intervals after surgery until 2 years. The percentage total weight loss was significantly higher in the MGB group compared to the RYGB group at all time points. At 2 years, MGB and RYGB both led to an increase in anaemia rates but the difference was only significant for MGB group. Compared to RYGB, MGB patients were more likely to be anaemic at 2 years, although the difference was not significant statistically (16.6% vs. 12.7%; P value = 0.55). There was a trend for lower iron and folate levels in MGB group compared to RYGB group but the difference was statistically significant at some of the time periods only (significantly lower folate at 6 and 12 months and lower iron at 6 months in the MGB group). MGB leads to a significant increase in anaemia rates in a supplemented cohort. There is a trend towards lower iron and folate levels and higher anaemia rates in MGB group in comparison with RYGB. Larger studies with longer follow-up should evaluate results of MGB with a shorter biliopancreatic limb. SN - 1758-8111 UR - https://www.unboundmedicine.com/medline/citation/29063708/Haematological_indices_and_haematinic_levels_after_mini_gastric_bypass:_a_matched_comparison_with_Roux_en_Y_gastric_bypass_ L2 - https://doi.org/10.1111/cob.12227 DB - PRIME DP - Unbound Medicine ER -