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The Role of Nicotine Dependence in E-Cigarettes' Potential for Smoking Reduction.
Nicotine Tob Res. 2018 09 04; 20(10):1272-1277.NT

Abstract

Introduction

E-cigarettes (Electronic Nicotine Delivery Systems, or ENDS) are an increasingly popular tobacco product among youth. Some evidence suggests that e-cigarettes may be effective for harm reduction and smoking cessation, although these claims remain controversial. Little is known about how nicotine dependence may contribute to e-cigarettes' effectiveness in reducing or quitting conventional smoking.

Methods

A cohort of young adults were surveyed over 4 years (approximately ages 19-23). Varying-coefficient models (VCMs) were used to examine the relationship between e-cigarette use and conventional smoking frequency, and how this relationship varies across users with different nicotine dependence levels.

Results

Lifetime, but not recent, e-cigarette use was associated with less frequent concurrent smoking of conventional cigarettes among those with high levels of nicotine dependence. However, nondependent e-cigarette users smoked conventional cigarettes slightly more frequently than those who had never used e-cigarettes. Nearly half of ever e-cigarette users reported using them to quit smoking at the last measurement wave. For those who used e-cigarettes in a cessation attempt, the frequency of e-cigarette use was not associated with reductions in future conventional smoking frequency.

Conclusions

These findings offer possible support that e-cigarettes may act as a smoking reduction method among highly nicotine-dependent young adult cigarette smokers. However, the opposite was found in non-dependent smokers, suggesting that e-cigarette use should be discouraged among novice tobacco users. Additionally, although a substantial proportion of young adults used e-cigarettes to help them quit smoking, these self-initiated quit attempts with e-cigarettes were not associated with future smoking reduction or cessation.

Implications

This study offers potential support for e-cigarettes as a smoking reduction tool among highly nicotine-dependent young adult conventional smokers, although the extent and nature of this remains unclear. The use of e-cigarettes as a quit aid was not associated with reductions in conventional smoking, consistent with most other quit aids in this sample except for nicotine replacement therapy, which was only effective for the most dependent smokers. Notably, these findings highlight the necessity of accounting for smokers' nicotine dependence levels when examining tobacco use patterns.

Authors+Show Affiliations

Department of Population Health, University of North Dakota, Grand Forks, ND.Psychology Department, Wesleyan University, Middletown, CT.Psychology Department, Wesleyan University, Middletown, CT.Department of Public Health Sciences, University of Chicago, Chicago, IL.Institute for Health Research and Policy, University of Illinois at Chicago, Chicago, IL.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

29065204

Citation

Selya, Arielle S., et al. "The Role of Nicotine Dependence in E-Cigarettes' Potential for Smoking Reduction." Nicotine & Tobacco Research : Official Journal of the Society for Research On Nicotine and Tobacco, vol. 20, no. 10, 2018, pp. 1272-1277.
Selya AS, Dierker L, Rose JS, et al. The Role of Nicotine Dependence in E-Cigarettes' Potential for Smoking Reduction. Nicotine Tob Res. 2018;20(10):1272-1277.
Selya, A. S., Dierker, L., Rose, J. S., Hedeker, D., & Mermelstein, R. J. (2018). The Role of Nicotine Dependence in E-Cigarettes' Potential for Smoking Reduction. Nicotine & Tobacco Research : Official Journal of the Society for Research On Nicotine and Tobacco, 20(10), 1272-1277. https://doi.org/10.1093/ntr/ntx160
Selya AS, et al. The Role of Nicotine Dependence in E-Cigarettes' Potential for Smoking Reduction. Nicotine Tob Res. 2018 09 4;20(10):1272-1277. PubMed PMID: 29065204.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Role of Nicotine Dependence in E-Cigarettes' Potential for Smoking Reduction. AU - Selya,Arielle S, AU - Dierker,Lisa, AU - Rose,Jennifer S, AU - Hedeker,Donald, AU - Mermelstein,Robin J, PY - 2017/03/02/received PY - 2017/07/05/accepted PY - 2017/10/25/pubmed PY - 2019/9/19/medline PY - 2017/10/25/entrez SP - 1272 EP - 1277 JF - Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco JO - Nicotine Tob Res VL - 20 IS - 10 N2 - Introduction: E-cigarettes (Electronic Nicotine Delivery Systems, or ENDS) are an increasingly popular tobacco product among youth. Some evidence suggests that e-cigarettes may be effective for harm reduction and smoking cessation, although these claims remain controversial. Little is known about how nicotine dependence may contribute to e-cigarettes' effectiveness in reducing or quitting conventional smoking. Methods: A cohort of young adults were surveyed over 4 years (approximately ages 19-23). Varying-coefficient models (VCMs) were used to examine the relationship between e-cigarette use and conventional smoking frequency, and how this relationship varies across users with different nicotine dependence levels. Results: Lifetime, but not recent, e-cigarette use was associated with less frequent concurrent smoking of conventional cigarettes among those with high levels of nicotine dependence. However, nondependent e-cigarette users smoked conventional cigarettes slightly more frequently than those who had never used e-cigarettes. Nearly half of ever e-cigarette users reported using them to quit smoking at the last measurement wave. For those who used e-cigarettes in a cessation attempt, the frequency of e-cigarette use was not associated with reductions in future conventional smoking frequency. Conclusions: These findings offer possible support that e-cigarettes may act as a smoking reduction method among highly nicotine-dependent young adult cigarette smokers. However, the opposite was found in non-dependent smokers, suggesting that e-cigarette use should be discouraged among novice tobacco users. Additionally, although a substantial proportion of young adults used e-cigarettes to help them quit smoking, these self-initiated quit attempts with e-cigarettes were not associated with future smoking reduction or cessation. Implications: This study offers potential support for e-cigarettes as a smoking reduction tool among highly nicotine-dependent young adult conventional smokers, although the extent and nature of this remains unclear. The use of e-cigarettes as a quit aid was not associated with reductions in conventional smoking, consistent with most other quit aids in this sample except for nicotine replacement therapy, which was only effective for the most dependent smokers. Notably, these findings highlight the necessity of accounting for smokers' nicotine dependence levels when examining tobacco use patterns. SN - 1469-994X UR - https://www.unboundmedicine.com/medline/citation/29065204/The_Role_of_Nicotine_Dependence_in_E_Cigarettes'_Potential_for_Smoking_Reduction_ L2 - https://academic.oup.com/ntr/article-lookup/doi/10.1093/ntr/ntx160 DB - PRIME DP - Unbound Medicine ER -