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CD4+, CD8+ cells, IgE and prick test in infants allergic to cow's milk.

Abstract

Three groups of infants were formed according to the type of feeding: I-breast milk from mothers without any kind of elimination diet, II-cow's milk-based formula, and III-breast milk till 2 months of age and after that, cow's milk formula. CD4 and CD8 were determined by monoclonal antibodies technique, IgE by ELISA and prick test with either intact or enzymatically digested cow's milk antigens. The average age of onset of the atopic disease in the first group was 2m 10d +/- 15d, in the second: 3m 4d +/- 14d, and in the third: 2m 11d +/- 1m 18d. The number of CD4 in group II was the lowest while in group III was the highest. CD8 value in the second group was higher than in the others. Ratio between CD4 and CD8 in cow's milk-fed infants was the lowest. Total serum IgE level in group II was the lowest although the mean values of the three groups were significantly increased. Prick tests, with at least one antigen, were positive in 75%, 50% and 48% in group I, II and III respectively. It is suggested that the behaviour of the parameters studied would be related to the dose of cow's milk proteins received through breast milk in breast-fed infants; to the relatively great amount of cow's milk antigens and to the lack of breast-feeding in infants fed on cow's milk formula; and to the interaction of such factors in infants fed with both cow's milk and breast milk.

Authors+Show Affiliations

,

Department of Microbiology and Immunology, National University of Rio Cuarto, Argentina.

Source

MeSH

Animals
Breast Feeding
CD4-Positive T-Lymphocytes
Cattle
Food Hypersensitivity
Humans
Hypersensitivity, Immediate
Immunoglobulin E
Infant
Infant Food
Intradermal Tests
Milk
Milk Proteins
T-Lymphocytes, Regulatory

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

2906523

Citation

Vanella, L, and A M. de González Lascano. "CD4+, CD8+ Cells, IgE and Prick Test in Infants Allergic to Cow's Milk." Allergologia Et Immunopathologia, vol. 16, no. 5, 1988, pp. 327-31.
Vanella L, de González Lascano AM. CD4+, CD8+ cells, IgE and prick test in infants allergic to cow's milk. Allergol Immunopathol (Madr). 1988;16(5):327-31.
Vanella, L., & de González Lascano, A. M. (1988). CD4+, CD8+ cells, IgE and prick test in infants allergic to cow's milk. Allergologia Et Immunopathologia, 16(5), pp. 327-31.
Vanella L, de González Lascano AM. CD4+, CD8+ Cells, IgE and Prick Test in Infants Allergic to Cow's Milk. Allergol Immunopathol (Madr). 1988;16(5):327-31. PubMed PMID: 2906523.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CD4+, CD8+ cells, IgE and prick test in infants allergic to cow's milk. AU - Vanella,L, AU - de González Lascano,A M, PY - 1988/9/1/pubmed PY - 1988/9/1/medline PY - 1988/9/1/entrez SP - 327 EP - 31 JF - Allergologia et immunopathologia JO - Allergol Immunopathol (Madr) VL - 16 IS - 5 N2 - Three groups of infants were formed according to the type of feeding: I-breast milk from mothers without any kind of elimination diet, II-cow's milk-based formula, and III-breast milk till 2 months of age and after that, cow's milk formula. CD4 and CD8 were determined by monoclonal antibodies technique, IgE by ELISA and prick test with either intact or enzymatically digested cow's milk antigens. The average age of onset of the atopic disease in the first group was 2m 10d +/- 15d, in the second: 3m 4d +/- 14d, and in the third: 2m 11d +/- 1m 18d. The number of CD4 in group II was the lowest while in group III was the highest. CD8 value in the second group was higher than in the others. Ratio between CD4 and CD8 in cow's milk-fed infants was the lowest. Total serum IgE level in group II was the lowest although the mean values of the three groups were significantly increased. Prick tests, with at least one antigen, were positive in 75%, 50% and 48% in group I, II and III respectively. It is suggested that the behaviour of the parameters studied would be related to the dose of cow's milk proteins received through breast milk in breast-fed infants; to the relatively great amount of cow's milk antigens and to the lack of breast-feeding in infants fed on cow's milk formula; and to the interaction of such factors in infants fed with both cow's milk and breast milk. SN - 0301-0546 UR - https://www.unboundmedicine.com/medline/citation/2906523/CD4+_CD8+_cells_IgE_and_prick_test_in_infants_allergic_to_cow's_milk_ L2 - https://medlineplus.gov/foodallergy.html DB - PRIME DP - Unbound Medicine ER -