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Case-Control Study of Papillary Thyroid Carcinoma on Urinary and Dietary Iodine Status in South Korea.
World J Surg. 2018 05; 42(5):1424-1431.WJ

Abstract

BACKGROUND

The association between iodine levels and the risk of papillary thyroid cancer (PTC) has been suggested, but not definitively established. This study is to compare the iodine status of a group of patients with PTC (with and without BRAF V600E) with that of a healthy population cohort.

METHODS

A cohort of patients scheduled for thyroidectomy was enrolled, along with a community-based health-screening cohort with no known history of thyroid disease. Median urinary iodine (UI) levels, creatinine-adjusted median UI levels, and food frequency questionnaire (FFQ) scores (mean ± SD) were compared. In a subgroup analysis, these values were compared between BRAF V600E-positive and BRAF V600E-negative patients in the PTC group.

RESULTS

The PTC group consisted of 210 patients, and the control group consisted of 90 healthy individuals. Among the 191 PTC patients whose BRAF V600E mutational status was reported, 169 (88.5%) were revealed positive for the mutation. The median UI levels were significantly higher in the PTC group (786.0 μg/l) than the control group (112.0 μg/l; p < 0.001), as was the case with creatinine-adjusted median UI levels (884.6 μg/g creatinine versus 182.0 μg/g creatinine; p < 0.001) and FFQ scores (66.2 ± 17.5, range 13-114 versus 54.6 ± 21.5, range 16-134; p < 0.001). No significant differences were seen in the subgroup analysis between BRAF V600E-positive and BRAF V600E-negative patients.

CONCLUSIONS

Our results indicate that iodine status differs significantly between patients with PTC and healthy controls, suggesting that iodine may be involved in the occurrence of PTC, although the association between iodine levels and BRAF mutational status did not reach statistical significance.

Authors+Show Affiliations

Department of Surgery, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, Seongnam-si, Gyeonggi-do, Republic of Korea. Thyroid and Endocrine Surgery Section, Department of Surgery, Gachon University Gil Medical Center, Incheon, Republic of Korea.Department of Surgery, Seoul National University Hospital and College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, Republic of Korea.Department of Surgery, Seoul National University Hospital and College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, Republic of Korea.Department of Surgery, Seoul National University Hospital and College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, Republic of Korea.Department of Surgery, Seoul National University Hospital and College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, Republic of Korea.Department of Surgery, Seoul National University Hospital and College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, Republic of Korea. Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.Department of Surgery, Seoul National University Hospital Boramae Medical Center, Seoul, Republic of Korea.Department of Surgery, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, Seongnam-si, Gyeonggi-do, Republic of Korea.Department of Internal Medicine, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, Seongnam-si, Gyeonggi-do, Republic of Korea.Department of Surgery, Seoul National University Hospital and College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, Republic of Korea. kyueunlee@snu.ac.kr. Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. kyueunlee@snu.ac.kr.Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. Department of Internal Medicine, Seoul National University Hospital and College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, Republic of Korea.Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. Department of Preventive Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, Republic of Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29067516

Citation

Lee, Joon-Hyop, et al. "Case-Control Study of Papillary Thyroid Carcinoma On Urinary and Dietary Iodine Status in South Korea." World Journal of Surgery, vol. 42, no. 5, 2018, pp. 1424-1431.
Lee JH, Song RY, Yi JW, et al. Case-Control Study of Papillary Thyroid Carcinoma on Urinary and Dietary Iodine Status in South Korea. World J Surg. 2018;42(5):1424-1431.
Lee, J. H., Song, R. Y., Yi, J. W., Yu, H. W., Kwon, H., Kim, S. J., Chai, Y. J., Choi, J. Y., Moon, J. H., Lee, K. E., Park, Y. J., & Park, S. K. (2018). Case-Control Study of Papillary Thyroid Carcinoma on Urinary and Dietary Iodine Status in South Korea. World Journal of Surgery, 42(5), 1424-1431. https://doi.org/10.1007/s00268-017-4287-x
Lee JH, et al. Case-Control Study of Papillary Thyroid Carcinoma On Urinary and Dietary Iodine Status in South Korea. World J Surg. 2018;42(5):1424-1431. PubMed PMID: 29067516.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Case-Control Study of Papillary Thyroid Carcinoma on Urinary and Dietary Iodine Status in South Korea. AU - Lee,Joon-Hyop, AU - Song,Ra-Yeong, AU - Yi,Jin Wook, AU - Yu,Hyeong Won, AU - Kwon,Hyungju, AU - Kim,Su-Jin, AU - Chai,Young Jun, AU - Choi,June Young, AU - Moon,Jae Hoon, AU - Lee,Kyu Eun, AU - Park,Young Joo, AU - Park,Sue K, PY - 2017/10/27/pubmed PY - 2018/9/6/medline PY - 2017/10/26/entrez SP - 1424 EP - 1431 JF - World journal of surgery JO - World J Surg VL - 42 IS - 5 N2 - BACKGROUND: The association between iodine levels and the risk of papillary thyroid cancer (PTC) has been suggested, but not definitively established. This study is to compare the iodine status of a group of patients with PTC (with and without BRAF V600E) with that of a healthy population cohort. METHODS: A cohort of patients scheduled for thyroidectomy was enrolled, along with a community-based health-screening cohort with no known history of thyroid disease. Median urinary iodine (UI) levels, creatinine-adjusted median UI levels, and food frequency questionnaire (FFQ) scores (mean ± SD) were compared. In a subgroup analysis, these values were compared between BRAF V600E-positive and BRAF V600E-negative patients in the PTC group. RESULTS: The PTC group consisted of 210 patients, and the control group consisted of 90 healthy individuals. Among the 191 PTC patients whose BRAF V600E mutational status was reported, 169 (88.5%) were revealed positive for the mutation. The median UI levels were significantly higher in the PTC group (786.0 μg/l) than the control group (112.0 μg/l; p < 0.001), as was the case with creatinine-adjusted median UI levels (884.6 μg/g creatinine versus 182.0 μg/g creatinine; p < 0.001) and FFQ scores (66.2 ± 17.5, range 13-114 versus 54.6 ± 21.5, range 16-134; p < 0.001). No significant differences were seen in the subgroup analysis between BRAF V600E-positive and BRAF V600E-negative patients. CONCLUSIONS: Our results indicate that iodine status differs significantly between patients with PTC and healthy controls, suggesting that iodine may be involved in the occurrence of PTC, although the association between iodine levels and BRAF mutational status did not reach statistical significance. SN - 1432-2323 UR - https://www.unboundmedicine.com/medline/citation/29067516/Case_Control_Study_of_Papillary_Thyroid_Carcinoma_on_Urinary_and_Dietary_Iodine_Status_in_South_Korea_ L2 - https://dx.doi.org/10.1007/s00268-017-4287-x DB - PRIME DP - Unbound Medicine ER -