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Serum ICAM-1, VCAM-1 and E-selectin levels in patients with primary and secondary Sjögren's syndrome.
Adv Clin Exp Med. 2017 Aug; 26(5):835-842.AC

Abstract

BACKGROUND

Typical features of Sjögren's syndrome (SS) are severe xerostomia and xerophthalmia which are basic diagnostic criteria.

OBJECTIVES

The aim of this study was to compare the serum levels of soluble (s) intercellular adhesion molecule 1 (sICAM-1), vascular cell adhesion molecule 1 (sVCAM-1) and sE-selectin between primary (pSS), secondary (sSS) and healthy subjects (HS). We correlated these results with selected clinical parameters of disease activity and parameters of the severity of xerostomia and xerophthalmia.

MATERIAL AND METHODS

The serum levels of sICAM-1, sVCAM-1 and sE-selectin were determined by enzyme-linked immunosorbent assay (ELISA) in 16 patients with pSS, 18 with sSS and 15 HS. Eye dryness and xerostomia were assessed by the Schirmer's test, the Fox test and the visual analogue scale (VAS).

RESULTS

The levels of sICAM-1 in pSS and sVCAM-1 in sSS patients were significantly higher when compared to HS (p = 0.02 and p = 0.048, respectively). There were no differences between pSS and sSS. In pSS, sVCAM-1 correlated positively with VAS (rS = 0.52, p = 0.04) and the Fox test (rS = 0.66, p=0.01). In sSS, sE-selectin correlated positively with sICAM-1 (rS = 0.54, p = 0.01), the duration of the disease (rS = 0.51, p = 0.03) and negatively with the Schirmer's test (rS = 0.59, p = 0.04). sICAM-1 correlated positively with the erythrocyte sedimentation rate (ESR) value (rS = 0.59, p = 0.01).

CONCLUSIONS

sVCAM-1 reflects xerostomia in pSS. sICAM-1 and sE-selectin may be additional parameters of sSS activity.

Authors+Show Affiliations

Department of Oral Surgery, Poznan University of Medical Sciences, Poland.Department of Rheumatology and Clinical Immunology, Poznan University of Medical Sciences, Poland.Department of Rheumatology and Clinical Immunology, Poznan University of Medical Sciences, Poland.Department of Ophthalmology, Poznan University of Medical Sciences, Poland.Department of Ophthalmology, Poznan University of Medical Sciences, Poland.Department of Plastic, Reconstructive and Aesthetic Surgery, Nicolaus Copernicus University Torun, Collegium Medicum, Bydgoszcz, Poland.Department of Oral Surgery, Poznan University of Medical Sciences, Poland.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

29068581

Citation

Błochowiak, Katarzyna J., et al. "Serum ICAM-1, VCAM-1 and E-selectin Levels in Patients With Primary and Secondary Sjögren's Syndrome." Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University, vol. 26, no. 5, 2017, pp. 835-842.
Błochowiak KJ, Olewicz-Gawlik A, Trzybulska D, et al. Serum ICAM-1, VCAM-1 and E-selectin levels in patients with primary and secondary Sjögren's syndrome. Adv Clin Exp Med. 2017;26(5):835-842.
Błochowiak, K. J., Olewicz-Gawlik, A., Trzybulska, D., Nowak-Gabryel, M., Kocięcki, J., Witmanowski, H., & Sokalski, J. (2017). Serum ICAM-1, VCAM-1 and E-selectin levels in patients with primary and secondary Sjögren's syndrome. Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University, 26(5), 835-842. https://doi.org/10.17219/acem/61434
Błochowiak KJ, et al. Serum ICAM-1, VCAM-1 and E-selectin Levels in Patients With Primary and Secondary Sjögren's Syndrome. Adv Clin Exp Med. 2017;26(5):835-842. PubMed PMID: 29068581.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum ICAM-1, VCAM-1 and E-selectin levels in patients with primary and secondary Sjögren's syndrome. AU - Błochowiak,Katarzyna J, AU - Olewicz-Gawlik,Anna, AU - Trzybulska,Dorota, AU - Nowak-Gabryel,Michalina, AU - Kocięcki,Jarosław, AU - Witmanowski,Henryk, AU - Sokalski,Jerzy, PY - 2017/10/26/entrez PY - 2017/10/27/pubmed PY - 2018/2/14/medline KW - Sjögren’s syndrome KW - sE-selectin KW - sICAM-1 KW - sVCAM-1 KW - xerostomia SP - 835 EP - 842 JF - Advances in clinical and experimental medicine : official organ Wroclaw Medical University JO - Adv Clin Exp Med VL - 26 IS - 5 N2 - BACKGROUND: Typical features of Sjögren's syndrome (SS) are severe xerostomia and xerophthalmia which are basic diagnostic criteria. OBJECTIVES: The aim of this study was to compare the serum levels of soluble (s) intercellular adhesion molecule 1 (sICAM-1), vascular cell adhesion molecule 1 (sVCAM-1) and sE-selectin between primary (pSS), secondary (sSS) and healthy subjects (HS). We correlated these results with selected clinical parameters of disease activity and parameters of the severity of xerostomia and xerophthalmia. MATERIAL AND METHODS: The serum levels of sICAM-1, sVCAM-1 and sE-selectin were determined by enzyme-linked immunosorbent assay (ELISA) in 16 patients with pSS, 18 with sSS and 15 HS. Eye dryness and xerostomia were assessed by the Schirmer's test, the Fox test and the visual analogue scale (VAS). RESULTS: The levels of sICAM-1 in pSS and sVCAM-1 in sSS patients were significantly higher when compared to HS (p = 0.02 and p = 0.048, respectively). There were no differences between pSS and sSS. In pSS, sVCAM-1 correlated positively with VAS (rS = 0.52, p = 0.04) and the Fox test (rS = 0.66, p=0.01). In sSS, sE-selectin correlated positively with sICAM-1 (rS = 0.54, p = 0.01), the duration of the disease (rS = 0.51, p = 0.03) and negatively with the Schirmer's test (rS = 0.59, p = 0.04). sICAM-1 correlated positively with the erythrocyte sedimentation rate (ESR) value (rS = 0.59, p = 0.01). CONCLUSIONS: sVCAM-1 reflects xerostomia in pSS. sICAM-1 and sE-selectin may be additional parameters of sSS activity. SN - 1899-5276 UR - https://www.unboundmedicine.com/medline/citation/29068581/Serum_ICAM_1_VCAM_1_and_E_selectin_levels_in_patients_with_primary_and_secondary_Sjögren's_syndrome_ L2 - http://www.advances.am.wroc.pl/pdf/2017/26/5/835.pdf DB - PRIME DP - Unbound Medicine ER -