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[A case of anti-MOG antibody-positive multiphasic disseminated encephalomyelitis co-occurring with unilateral cerebral cortical encephalitis].
Rinsho Shinkeigaku. 2017 Nov 25; 57(11):723-728.RS

Abstract

A 20-year-old woman first developed acute disseminated encephalomyelitis (ADEM) at 11 years of age. At 17 years of age, she was hospitalized due to generalized seizure and diagnosed with encephalitis. Brain MRI revealed a FLAIR-hyperintense lesion in the unilateral cerebral cortex. At 18 years of age, serum anti-myelin oligodendrocyte glycoprotein (MOG) antibody was detected. At 20 years of age, she was admitted to our hospital, diagnosed with multifocal disseminated encephalomyelitis (MDEM). MDEM has been observed in patients that are seropositive for the anti-MOG antibody. More recently, unilateral cerebral cortex encephalitis with epilepsy has also been reported in such patients. The co-occurrence of MDEM and cortical encephalitis in the same patient has important implications for the pathogenesis of anti-MOG antibody-associated autoimmune diseases.

Authors+Show Affiliations

Division of Neurology, Department of Internal Medicine, Tokyo Women's Medical University Yachiyo Medical Center.Division of Neurology, Department of Internal Medicine, Tokyo Women's Medical University Yachiyo Medical Center.Department of Neurology, Tohoku University Graduate School of Medicine.Division of Pediatric Neurology, Department of Pediatrics, Tokyo Women's Medical University Yachiyo Medical Center.Division of Pediatric Neurology, Department of Pediatrics, Tokyo Women's Medical University Yachiyo Medical Center.Division of Neurology, Department of Internal Medicine, Tokyo Women's Medical University Yachiyo Medical Center.

Pub Type(s)

Case Reports
Journal Article

Language

jpn

PubMed ID

29070756

Citation

Fukushima, Naoya, et al. "[A Case of anti-MOG Antibody-positive Multiphasic Disseminated Encephalomyelitis Co-occurring With Unilateral Cerebral Cortical Encephalitis]." Rinsho Shinkeigaku = Clinical Neurology, vol. 57, no. 11, 2017, pp. 723-728.
Fukushima N, Suzuki M, Ogawa R, et al. [A case of anti-MOG antibody-positive multiphasic disseminated encephalomyelitis co-occurring with unilateral cerebral cortical encephalitis]. Rinsho Shinkeigaku. 2017;57(11):723-728.
Fukushima, N., Suzuki, M., Ogawa, R., Hayashi, K., Takanashi, J. I., & Ohashi, T. (2017). [A case of anti-MOG antibody-positive multiphasic disseminated encephalomyelitis co-occurring with unilateral cerebral cortical encephalitis]. Rinsho Shinkeigaku = Clinical Neurology, 57(11), 723-728. https://doi.org/10.5692/clinicalneurol.cn-001078
Fukushima N, et al. [A Case of anti-MOG Antibody-positive Multiphasic Disseminated Encephalomyelitis Co-occurring With Unilateral Cerebral Cortical Encephalitis]. Rinsho Shinkeigaku. 2017 Nov 25;57(11):723-728. PubMed PMID: 29070756.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [A case of anti-MOG antibody-positive multiphasic disseminated encephalomyelitis co-occurring with unilateral cerebral cortical encephalitis]. AU - Fukushima,Naoya, AU - Suzuki,Miki, AU - Ogawa,Ryo, AU - Hayashi,Kitami, AU - Takanashi,Jun-Ichi, AU - Ohashi,Takashi, Y1 - 2017/10/26/ PY - 2017/10/27/pubmed PY - 2018/1/4/medline PY - 2017/10/27/entrez KW - anti-MOG antibody KW - encephalitis KW - epileptic seizure KW - magnetic resonance spectroscopy KW - multiphasic disseminated encephalomyelitis SP - 723 EP - 728 JF - Rinsho shinkeigaku = Clinical neurology JO - Rinsho Shinkeigaku VL - 57 IS - 11 N2 - A 20-year-old woman first developed acute disseminated encephalomyelitis (ADEM) at 11 years of age. At 17 years of age, she was hospitalized due to generalized seizure and diagnosed with encephalitis. Brain MRI revealed a FLAIR-hyperintense lesion in the unilateral cerebral cortex. At 18 years of age, serum anti-myelin oligodendrocyte glycoprotein (MOG) antibody was detected. At 20 years of age, she was admitted to our hospital, diagnosed with multifocal disseminated encephalomyelitis (MDEM). MDEM has been observed in patients that are seropositive for the anti-MOG antibody. More recently, unilateral cerebral cortex encephalitis with epilepsy has also been reported in such patients. The co-occurrence of MDEM and cortical encephalitis in the same patient has important implications for the pathogenesis of anti-MOG antibody-associated autoimmune diseases. SN - 1882-0654 UR - https://www.unboundmedicine.com/medline/citation/29070756/[A_case_of_anti_MOG_antibody_positive_multiphasic_disseminated_encephalomyelitis_co_occurring_with_unilateral_cerebral_cortical_encephalitis]_ L2 - https://dx.doi.org/10.5692/clinicalneurol.cn-001078 DB - PRIME DP - Unbound Medicine ER -