Tags

Type your tag names separated by a space and hit enter

The synergic effect of BRAFV600E mutation and multifocality on central lymph node metastasis in unilateral papillary thyroid carcinoma.
Endocr J. 2018 Jan 30; 65(1):113-120.EJ

Abstract

The purpose of this study is to evaluate the potential synergic effect of BRAFV600E mutation and multifocality on central lymph nodes metastasis (CLNM) in the patients with unilateral papillary thyroid carcinoma (PTC). We enrolled 413 patients with unilateral PTCs who accepted prophylactic unilateral or bilateral central lymph node dissection (LND). Univariate and multivariate analyses were made to determine the association between related factors and CLNM. Then, all patients were divided into 4 groups based on their status of BRAFV600E mutation and multifocality. Relative excess risk of interaction (RERI), attributable proportion (AP) of interaction and synergy index (SI) were applied to evaluate the interactive effect of these two factors on CLNM. Results showed that BRAFV600E mutation and multifocality were independent risk factors for CLNM. A further study revealed that unilateral PTCs accompanying multifocality with BRAFV600E mutation had the highest incidence of CLNM compared with other subgroups. Besides, RERI was 4.323 (95% CI = 1.276-7.369), AP was 0.523 (95% CI = 0.364-0.682) and SI was 2.469 (95% CI = 1.607 to 3.794), indicating a significant additive interaction of BRAFV600E mutation and multifocality on CLNM. The present study has confirmed that BRAFV600E mutation and multifocality are risk factors for CLNM in unilateral PTC. Additionally, unilateral PTC patients accompanying multifocality with BRAFV600E mutation may have an increased risk of CLNM in clinically negative CLNM.

Authors+Show Affiliations

The Department of Thyroid and Breast, Taizhou Cancer Hospital, Wenling, Zhejiang, China.Nursing Department, The First People's Hospital of Wenling, Wenling City, Zhejiang, China.The Department of Thyroid and Breast, Taizhou Cancer Hospital, Wenling, Zhejiang, China.Department of Laboratory Medicine, Taizhou Cancer Hospital, Wenling, Zhejiang, China.Department of Laboratory Medicine, Wenling Women's and Children's Hospital, Wenling, Zhejiang, China.Department of Ultrasound, Taizhou Cancer Hospital, Wenling, Zhejiang, China.Department of Head and Neck Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29070763

Citation

Qu, Hai-Jiang, et al. "The Synergic Effect of BRAFV600E Mutation and Multifocality On Central Lymph Node Metastasis in Unilateral Papillary Thyroid Carcinoma." Endocrine Journal, vol. 65, no. 1, 2018, pp. 113-120.
Qu HJ, Qu XY, Hu Z, et al. The synergic effect of BRAFV600E mutation and multifocality on central lymph node metastasis in unilateral papillary thyroid carcinoma. Endocr J. 2018;65(1):113-120.
Qu, H. J., Qu, X. Y., Hu, Z., Lin, Y., Wang, J. R., Zheng, C. F., & Tan, Z. (2018). The synergic effect of BRAFV600E mutation and multifocality on central lymph node metastasis in unilateral papillary thyroid carcinoma. Endocrine Journal, 65(1), 113-120. https://doi.org/10.1507/endocrj.EJ17-0110
Qu HJ, et al. The Synergic Effect of BRAFV600E Mutation and Multifocality On Central Lymph Node Metastasis in Unilateral Papillary Thyroid Carcinoma. Endocr J. 2018 Jan 30;65(1):113-120. PubMed PMID: 29070763.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The synergic effect of BRAFV600E mutation and multifocality on central lymph node metastasis in unilateral papillary thyroid carcinoma. AU - Qu,Hai-Jiang, AU - Qu,Xue-Yan, AU - Hu,Ze, AU - Lin,Yan, AU - Wang,Jun-Rong, AU - Zheng,Chang-Fu, AU - Tan,Zhuo, Y1 - 2017/10/26/ PY - 2017/10/27/pubmed PY - 2018/8/18/medline PY - 2017/10/27/entrez KW - BRAFV600E mutation KW - Central lymph node metastasis KW - Multifocality KW - Papillary thyroid carcinoma KW - Prophylactic lymph node dissection SP - 113 EP - 120 JF - Endocrine journal JO - Endocr. J. VL - 65 IS - 1 N2 - The purpose of this study is to evaluate the potential synergic effect of BRAFV600E mutation and multifocality on central lymph nodes metastasis (CLNM) in the patients with unilateral papillary thyroid carcinoma (PTC). We enrolled 413 patients with unilateral PTCs who accepted prophylactic unilateral or bilateral central lymph node dissection (LND). Univariate and multivariate analyses were made to determine the association between related factors and CLNM. Then, all patients were divided into 4 groups based on their status of BRAFV600E mutation and multifocality. Relative excess risk of interaction (RERI), attributable proportion (AP) of interaction and synergy index (SI) were applied to evaluate the interactive effect of these two factors on CLNM. Results showed that BRAFV600E mutation and multifocality were independent risk factors for CLNM. A further study revealed that unilateral PTCs accompanying multifocality with BRAFV600E mutation had the highest incidence of CLNM compared with other subgroups. Besides, RERI was 4.323 (95% CI = 1.276-7.369), AP was 0.523 (95% CI = 0.364-0.682) and SI was 2.469 (95% CI = 1.607 to 3.794), indicating a significant additive interaction of BRAFV600E mutation and multifocality on CLNM. The present study has confirmed that BRAFV600E mutation and multifocality are risk factors for CLNM in unilateral PTC. Additionally, unilateral PTC patients accompanying multifocality with BRAFV600E mutation may have an increased risk of CLNM in clinically negative CLNM. SN - 1348-4540 UR - https://www.unboundmedicine.com/medline/citation/29070763/The_synergic_effect_of_BRAFV600E_mutation_and_multifocality_on_central_lymph_node_metastasis_in_unilateral_papillary_thyroid_carcinoma_ L2 - https://dx.doi.org/10.1507/endocrj.EJ17-0110 DB - PRIME DP - Unbound Medicine ER -