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Design and evaluation of lidocaine- and prilocaine-coloaded nanoparticulate drug delivery systems for topical anesthetic analgesic therapy: a comparison between solid lipid nanoparticles and nanostructured lipid carriers.
Drug Des Devel Ther 2017; 11:2743-2752DD

Abstract

PURPOSE

Topical anesthesia analgesic therapy has diverse applicability in solving the barrier properties of skin and unfavorable physicochemical properties of drugs. Lidocaine (LID) combined with prilocaine (PRI) has been used as a topical preparation for dermal anesthesia for treatment of conditions such as paresthesia.

MATERIALS AND METHODS

In this study, for combination anesthesia and overcoming the drawbacks of LID and PRI, respectively, LID- and PRI-loaded solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) were prepared and characterized by determination of their particle size, drug loading capacity, stability, in vitro drug release behavior and in vitro cellular viability. Ex vivo skin permeation and in vivo anesthesia analgesic efficiency of these two systems were also evaluated and compared.

RESULTS

Results revealed that combination delivery of the dual drugs exhibited more remarkable efficiency than signal drug-loaded systems. SLN systems have better ex vivo skin permeation ability than NLCs. NLC systems revealed a stronger in vivo anesthesia analgesic effect than SLN systems.

CONCLUSION

It can be concluded that SLNs and NLCs have different advantages, and that both carriers are promising dual drug delivery systems for topical anesthetic analgesic therapy.

Authors+Show Affiliations

Department of Anesthesiology, Shandong Jining No 1 People's Hospital, Shandong, People's Republic of China.Department of Anesthesiology, Affiliated Hospital of Jining Medical College, Jining, Shandong, People's Republic of China.Department of Anesthesiology, Shandong Jining No 1 People's Hospital, Shandong, People's Republic of China.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

29075099

Citation

You, Peijun, et al. "Design and Evaluation of Lidocaine- and Prilocaine-coloaded Nanoparticulate Drug Delivery Systems for Topical Anesthetic Analgesic Therapy: a Comparison Between Solid Lipid Nanoparticles and Nanostructured Lipid Carriers." Drug Design, Development and Therapy, vol. 11, 2017, pp. 2743-2752.
You P, Yuan R, Chen C. Design and evaluation of lidocaine- and prilocaine-coloaded nanoparticulate drug delivery systems for topical anesthetic analgesic therapy: a comparison between solid lipid nanoparticles and nanostructured lipid carriers. Drug Des Devel Ther. 2017;11:2743-2752.
You, P., Yuan, R., & Chen, C. (2017). Design and evaluation of lidocaine- and prilocaine-coloaded nanoparticulate drug delivery systems for topical anesthetic analgesic therapy: a comparison between solid lipid nanoparticles and nanostructured lipid carriers. Drug Design, Development and Therapy, 11, pp. 2743-2752. doi:10.2147/DDDT.S141031.
You P, Yuan R, Chen C. Design and Evaluation of Lidocaine- and Prilocaine-coloaded Nanoparticulate Drug Delivery Systems for Topical Anesthetic Analgesic Therapy: a Comparison Between Solid Lipid Nanoparticles and Nanostructured Lipid Carriers. Drug Des Devel Ther. 2017;11:2743-2752. PubMed PMID: 29075099.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Design and evaluation of lidocaine- and prilocaine-coloaded nanoparticulate drug delivery systems for topical anesthetic analgesic therapy: a comparison between solid lipid nanoparticles and nanostructured lipid carriers. AU - You,Peijun, AU - Yuan,Ran, AU - Chen,Chuanyu, Y1 - 2017/09/18/ PY - 2017/10/28/entrez PY - 2017/10/28/pubmed PY - 2018/7/24/medline KW - lidocaine KW - nanostructured lipid carriers KW - prilocaine KW - solid lipid nanoparticles KW - topical anesthesia SP - 2743 EP - 2752 JF - Drug design, development and therapy JO - Drug Des Devel Ther VL - 11 N2 - PURPOSE: Topical anesthesia analgesic therapy has diverse applicability in solving the barrier properties of skin and unfavorable physicochemical properties of drugs. Lidocaine (LID) combined with prilocaine (PRI) has been used as a topical preparation for dermal anesthesia for treatment of conditions such as paresthesia. MATERIALS AND METHODS: In this study, for combination anesthesia and overcoming the drawbacks of LID and PRI, respectively, LID- and PRI-loaded solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) were prepared and characterized by determination of their particle size, drug loading capacity, stability, in vitro drug release behavior and in vitro cellular viability. Ex vivo skin permeation and in vivo anesthesia analgesic efficiency of these two systems were also evaluated and compared. RESULTS: Results revealed that combination delivery of the dual drugs exhibited more remarkable efficiency than signal drug-loaded systems. SLN systems have better ex vivo skin permeation ability than NLCs. NLC systems revealed a stronger in vivo anesthesia analgesic effect than SLN systems. CONCLUSION: It can be concluded that SLNs and NLCs have different advantages, and that both carriers are promising dual drug delivery systems for topical anesthetic analgesic therapy. SN - 1177-8881 UR - https://www.unboundmedicine.com/medline/citation/29075099/Design_and_evaluation_of_lidocaine__and_prilocaine_coloaded_nanoparticulate_drug_delivery_systems_for_topical_anesthetic_analgesic_therapy:_a_comparison_between_solid_lipid_nanoparticles_and_nanostructured_lipid_carriers_ L2 - https://dx.doi.org/10.2147/DDDT.S141031 DB - PRIME DP - Unbound Medicine ER -