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Coffee and green tea consumption and subsequent risk of acute myeloid leukemia and myelodysplastic syndromes in Japan.
Int J Cancer 2018; 142(6):1130-1138IJ

Abstract

Although coffee and green tea are suggested to reduce the risk of some types of cancers, only a few epidemiological studies have investigated their effect on the risk of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Here, we investigated the association of coffee and green tea consumption and the risk of AML and MDS in a large-scale population-based cohort study in Japan. A total of 95,807 Japanese subjects (45,937 men and 49,870 women; age 40-69 years at baseline) were followed to the end of 2012, for an average of 18 years. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) for the association between coffee and green tea consumption at baseline and the risk of AML and MDS were assessed using a Cox proportional hazards model with adjustment for potential confounders. During 1,751.956 person-years, we identified 85 AML cases and 70 MDS cases. Our findings showed no significant association between coffee consumption and the risk of AML, or between green tea consumption and the risk of AML or MDS. In contrast, we observed a decreasing dose-response relationship between coffee consumption and the risk of MDS among men (almost none: reference, 1-4 times/week: HR = 0.83, 95% CI: 0.43-1.62; ≥1cups/day: HR = 0.47, 0.22-0.99, p for trend = 0.049). Stratified analysis by smoking status suggested that the observed relative risk for AML and MDS of coffee drinkers relative to non-coffee drinkers might be due to residual confounding by smoking. These findings deserve further investigation in future studies.

Authors+Show Affiliations

Division of Molecular and Clinical Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan. Division of Hematology, Saitama Medical Center, Jichi Medical University, Omiya, Saitama, Japan.Division of Molecular and Clinical Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan. Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.Division of Hematology, Saitama Medical Center, Jichi Medical University, Omiya, Saitama, Japan.Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29076523

Citation

Ugai, Tomotaka, et al. "Coffee and Green Tea Consumption and Subsequent Risk of Acute Myeloid Leukemia and Myelodysplastic Syndromes in Japan." International Journal of Cancer, vol. 142, no. 6, 2018, pp. 1130-1138.
Ugai T, Matsuo K, Sawada N, et al. Coffee and green tea consumption and subsequent risk of acute myeloid leukemia and myelodysplastic syndromes in Japan. Int J Cancer. 2018;142(6):1130-1138.
Ugai, T., Matsuo, K., Sawada, N., Iwasaki, M., Yamaji, T., Shimazu, T., ... Tsugane, S. (2018). Coffee and green tea consumption and subsequent risk of acute myeloid leukemia and myelodysplastic syndromes in Japan. International Journal of Cancer, 142(6), pp. 1130-1138. doi:10.1002/ijc.31135.
Ugai T, et al. Coffee and Green Tea Consumption and Subsequent Risk of Acute Myeloid Leukemia and Myelodysplastic Syndromes in Japan. Int J Cancer. 2018 03 15;142(6):1130-1138. PubMed PMID: 29076523.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coffee and green tea consumption and subsequent risk of acute myeloid leukemia and myelodysplastic syndromes in Japan. AU - Ugai,Tomotaka, AU - Matsuo,Keitaro, AU - Sawada,Norie, AU - Iwasaki,Motoki, AU - Yamaji,Taiki, AU - Shimazu,Taichi, AU - Goto,Atsushi, AU - Inoue,Manami, AU - Kanda,Yoshinobu, AU - Tsugane,Shoichiro, AU - ,, Y1 - 2017/11/21/ PY - 2017/07/05/received PY - 2017/10/12/revised PY - 2017/10/19/accepted PY - 2017/10/28/pubmed PY - 2018/10/12/medline PY - 2017/10/28/entrez KW - JPHC study KW - acute myeloid leukemia KW - coffee KW - green tea KW - myelodysplastic syndrome KW - prospective SP - 1130 EP - 1138 JF - International journal of cancer JO - Int. J. Cancer VL - 142 IS - 6 N2 - Although coffee and green tea are suggested to reduce the risk of some types of cancers, only a few epidemiological studies have investigated their effect on the risk of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Here, we investigated the association of coffee and green tea consumption and the risk of AML and MDS in a large-scale population-based cohort study in Japan. A total of 95,807 Japanese subjects (45,937 men and 49,870 women; age 40-69 years at baseline) were followed to the end of 2012, for an average of 18 years. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) for the association between coffee and green tea consumption at baseline and the risk of AML and MDS were assessed using a Cox proportional hazards model with adjustment for potential confounders. During 1,751.956 person-years, we identified 85 AML cases and 70 MDS cases. Our findings showed no significant association between coffee consumption and the risk of AML, or between green tea consumption and the risk of AML or MDS. In contrast, we observed a decreasing dose-response relationship between coffee consumption and the risk of MDS among men (almost none: reference, 1-4 times/week: HR = 0.83, 95% CI: 0.43-1.62; ≥1cups/day: HR = 0.47, 0.22-0.99, p for trend = 0.049). Stratified analysis by smoking status suggested that the observed relative risk for AML and MDS of coffee drinkers relative to non-coffee drinkers might be due to residual confounding by smoking. These findings deserve further investigation in future studies. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/29076523/Coffee_and_green_tea_consumption_and_subsequent_risk_of_acute_myeloid_leukemia_and_myelodysplastic_syndromes_in_Japan_ L2 - https://doi.org/10.1002/ijc.31135 DB - PRIME DP - Unbound Medicine ER -