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Systematic review of community-based, school-based, and combined delivery modes for reaching school-aged children in mass drug administration programs for schistosomiasis.
PLoS Negl Trop Dis. 2017 Oct; 11(10):e0006043.PN

Abstract

BACKGROUND

The mainstay of current schistosomiasis control programs is mass preventive chemotherapy of school-aged children with praziquantel. This treatment is delivered through school-based, community-based, or combined school- and community-based systems. Attaining very high coverage rates for children is essential in mass schistosomiasis treatment programs, as is ensuring that there are no persistently untreated subpopulations, a potential challenge for school-based programs in areas with low school enrollment. This review sought to compare the different treatment delivery methods based both on their coverage of school-aged children overall and on their coverage specifically of non-enrolled children. In addition, qualitative community or programmatic factors associated with high or low coverage rates were identified, with suggestions for overall coverage improvement.

METHODOLOGY/PRINCIPAL FINDINGS

This review was registered prospectively with PROSPERO (CRD 42015017656). Five hundred forty-nine publication of potential relevance were identified through database searches, reference lists, and personal communications. Eligible studies included those published before October 2015, written in English or French, containing quantitative or qualitative data about coverage rates for MDA of school-aged children with praziquantel. Among the 22 selected studies, combined community- and school-based programs achieved the highest median coverage rates (89%), followed by community-based programs (72%). School-based programs had both the lowest median coverage of children overall (49%) and the lowest coverage of the non-enrolled subpopulation of children. Qualitatively, major factors affecting program success included fear of side effects, inadequate education about schistosomiasis, lack of incentives for drug distributors, and inequitable distribution to minority groups.

CONCLUSIONS/SIGNIFICANCE

This review provides an evidence-based framework for the development of future schistosomiasis control programs. Based on our results, a combined community and school-based delivery system should maximize coverage for both in- and out-of-school children, especially when combined with interventions such as snacks for treated children, educational campaigns, incentives for drug distributors, and active inclusion of marginalized groups.

TRIAL REGISTRATION

ClinicalTrials.gov CRD42015017656.

Authors+Show Affiliations

Center for Global Health and Diseases and WHO Collaborating Centre for Research and Training for Schistosomiasis Elimination, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America.Center for Global Health and Diseases and WHO Collaborating Centre for Research and Training for Schistosomiasis Elimination, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America.Center for Global Health and Diseases and WHO Collaborating Centre for Research and Training for Schistosomiasis Elimination, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America. Schistosomiasis Consortium for Operational Research and Evaluation, University of Georgia, Athens, Georgia, United States of America.

Pub Type(s)

Journal Article
Review
Systematic Review

Language

eng

PubMed ID

29077723

Citation

Burnim, Michael, et al. "Systematic Review of Community-based, School-based, and Combined Delivery Modes for Reaching School-aged Children in Mass Drug Administration Programs for Schistosomiasis." PLoS Neglected Tropical Diseases, vol. 11, no. 10, 2017, pp. e0006043.
Burnim M, Ivy JA, King CH. Systematic review of community-based, school-based, and combined delivery modes for reaching school-aged children in mass drug administration programs for schistosomiasis. PLoS Negl Trop Dis. 2017;11(10):e0006043.
Burnim, M., Ivy, J. A., & King, C. H. (2017). Systematic review of community-based, school-based, and combined delivery modes for reaching school-aged children in mass drug administration programs for schistosomiasis. PLoS Neglected Tropical Diseases, 11(10), e0006043. https://doi.org/10.1371/journal.pntd.0006043
Burnim M, Ivy JA, King CH. Systematic Review of Community-based, School-based, and Combined Delivery Modes for Reaching School-aged Children in Mass Drug Administration Programs for Schistosomiasis. PLoS Negl Trop Dis. 2017;11(10):e0006043. PubMed PMID: 29077723.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Systematic review of community-based, school-based, and combined delivery modes for reaching school-aged children in mass drug administration programs for schistosomiasis. AU - Burnim,Michael, AU - Ivy,Julianne A, AU - King,Charles H, Y1 - 2017/10/27/ PY - 2017/07/28/received PY - 2017/10/16/accepted PY - 2017/11/08/revised PY - 2017/10/28/pubmed PY - 2017/11/14/medline PY - 2017/10/28/entrez SP - e0006043 EP - e0006043 JF - PLoS neglected tropical diseases JO - PLoS Negl Trop Dis VL - 11 IS - 10 N2 - BACKGROUND: The mainstay of current schistosomiasis control programs is mass preventive chemotherapy of school-aged children with praziquantel. This treatment is delivered through school-based, community-based, or combined school- and community-based systems. Attaining very high coverage rates for children is essential in mass schistosomiasis treatment programs, as is ensuring that there are no persistently untreated subpopulations, a potential challenge for school-based programs in areas with low school enrollment. This review sought to compare the different treatment delivery methods based both on their coverage of school-aged children overall and on their coverage specifically of non-enrolled children. In addition, qualitative community or programmatic factors associated with high or low coverage rates were identified, with suggestions for overall coverage improvement. METHODOLOGY/PRINCIPAL FINDINGS: This review was registered prospectively with PROSPERO (CRD 42015017656). Five hundred forty-nine publication of potential relevance were identified through database searches, reference lists, and personal communications. Eligible studies included those published before October 2015, written in English or French, containing quantitative or qualitative data about coverage rates for MDA of school-aged children with praziquantel. Among the 22 selected studies, combined community- and school-based programs achieved the highest median coverage rates (89%), followed by community-based programs (72%). School-based programs had both the lowest median coverage of children overall (49%) and the lowest coverage of the non-enrolled subpopulation of children. Qualitatively, major factors affecting program success included fear of side effects, inadequate education about schistosomiasis, lack of incentives for drug distributors, and inequitable distribution to minority groups. CONCLUSIONS/SIGNIFICANCE: This review provides an evidence-based framework for the development of future schistosomiasis control programs. Based on our results, a combined community and school-based delivery system should maximize coverage for both in- and out-of-school children, especially when combined with interventions such as snacks for treated children, educational campaigns, incentives for drug distributors, and active inclusion of marginalized groups. TRIAL REGISTRATION: ClinicalTrials.gov CRD42015017656. SN - 1935-2735 UR - https://www.unboundmedicine.com/medline/citation/29077723/Systematic_review_of_community_based_school_based_and_combined_delivery_modes_for_reaching_school_aged_children_in_mass_drug_administration_programs_for_schistosomiasis_ L2 - http://dx.plos.org/10.1371/journal.pntd.0006043 DB - PRIME DP - Unbound Medicine ER -