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The Effects of Synbiotic Supplementation on Carotid Intima-Media Thickness, Biomarkers of Inflammation, and Oxidative Stress in People with Overweight, Diabetes, and Coronary Heart Disease: a Randomized, Double-Blind, Placebo-Controlled Trial.
Probiotics Antimicrob Proteins. 2019 03; 11(1):133-142.PA

Abstract

Synbiotics are known to exert multiple beneficial effects, including anti-inflammatory and antioxidant actions. The aim of this study was to evaluate the effects of synbiotic supplementation on carotid intima-media thickness (CIMT), biomarkers of inflammation, and oxidative stress in people with overweight, diabetes, and coronary heart disease (CHD). This randomized, double-blind, placebo-controlled trial was conducted and involved 60 people with overweight, diabetes, and CHD, aged 50-85 years old. Participants were randomly allocated into two groups to take either synbiotic supplements containing three probiotic bacteria spices Lactobacillus acidophilus strain T16 (IBRC-M10785), Lactobacillus casei strain T2 (IBRC-M10783), and Bifidobacterium bifidum strain T1 (IBRC-M10771) (2 × 109 CFU/g each) plus 800 mg inulin or placebo (n = 30 each group) for 12 weeks. Fasting blood samples were taken at baseline and after the 12-week intervention period to determine metabolic variables. After the 12-week intervention, compared with the placebo, synbiotic supplementation significantly reduced serum high-sensitivity C-reactive protein (hs-CRP) (- 3101.7 ± 5109.1 vs. - 6.2 ± 3163.6 ng/mL, P = 0.02), plasma malondialdehyde (MDA) (- 0.6 ± 1.0 vs. - 0.1 ± 0.3 μmol/L, P = 0.01), and significantly increased nitric oxide (NO) levels (+ 7.8 ± 10.3 vs. - 3.6 ± 6.9 μmol/L, P < 0.001). We did not observe any significant changes of synbiotic supplementation on other biomarkers of oxidative stress and CIMT levels. Overall, synbiotic supplementation for 12 weeks among people with overweight, diabetes, and CHD had beneficial effects on serum hs-CRP, plasma NO, and MDA levels; however, it did not have any effect on other biomarkers of oxidative stress and CIMT levels.

Authors+Show Affiliations

Department of Cardiology, School of Medicine, Kashan University of Medical Sciences, Kashan, I.R., Iran.Department of Cardiology, School of Medicine, Kashan University of Medical Sciences, Kashan, I.R., Iran.Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R., Iran.Science Department, Science Faculty, Islamic Azad University, Tehran Central Branch, Tehran, Iran.Department of Oncology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.Department of Urology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R., Iran. asemi_r@yahoo.com.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29079990

Citation

Farrokhian, Alireza, et al. "The Effects of Synbiotic Supplementation On Carotid Intima-Media Thickness, Biomarkers of Inflammation, and Oxidative Stress in People With Overweight, Diabetes, and Coronary Heart Disease: a Randomized, Double-Blind, Placebo-Controlled Trial." Probiotics and Antimicrobial Proteins, vol. 11, no. 1, 2019, pp. 133-142.
Farrokhian A, Raygan F, Soltani A, et al. The Effects of Synbiotic Supplementation on Carotid Intima-Media Thickness, Biomarkers of Inflammation, and Oxidative Stress in People with Overweight, Diabetes, and Coronary Heart Disease: a Randomized, Double-Blind, Placebo-Controlled Trial. Probiotics Antimicrob Proteins. 2019;11(1):133-142.
Farrokhian, A., Raygan, F., Soltani, A., Tajabadi-Ebrahimi, M., Sharifi Esfahani, M., Karami, A. A., & Asemi, Z. (2019). The Effects of Synbiotic Supplementation on Carotid Intima-Media Thickness, Biomarkers of Inflammation, and Oxidative Stress in People with Overweight, Diabetes, and Coronary Heart Disease: a Randomized, Double-Blind, Placebo-Controlled Trial. Probiotics and Antimicrobial Proteins, 11(1), 133-142. https://doi.org/10.1007/s12602-017-9343-1
Farrokhian A, et al. The Effects of Synbiotic Supplementation On Carotid Intima-Media Thickness, Biomarkers of Inflammation, and Oxidative Stress in People With Overweight, Diabetes, and Coronary Heart Disease: a Randomized, Double-Blind, Placebo-Controlled Trial. Probiotics Antimicrob Proteins. 2019;11(1):133-142. PubMed PMID: 29079990.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Effects of Synbiotic Supplementation on Carotid Intima-Media Thickness, Biomarkers of Inflammation, and Oxidative Stress in People with Overweight, Diabetes, and Coronary Heart Disease: a Randomized, Double-Blind, Placebo-Controlled Trial. AU - Farrokhian,Alireza, AU - Raygan,Fariba, AU - Soltani,Ali, AU - Tajabadi-Ebrahimi,Maryam, AU - Sharifi Esfahani,Mehran, AU - Karami,Ali Akbar, AU - Asemi,Zatollah, PY - 2017/10/29/pubmed PY - 2019/8/27/medline PY - 2017/10/29/entrez KW - Carotid intima-media thickness KW - Coronary heart disease KW - Inflammation KW - Oxidative stress KW - Synbiotic supplementation KW - Type 2 diabetes mellitus SP - 133 EP - 142 JF - Probiotics and antimicrobial proteins JO - Probiotics Antimicrob Proteins VL - 11 IS - 1 N2 - Synbiotics are known to exert multiple beneficial effects, including anti-inflammatory and antioxidant actions. The aim of this study was to evaluate the effects of synbiotic supplementation on carotid intima-media thickness (CIMT), biomarkers of inflammation, and oxidative stress in people with overweight, diabetes, and coronary heart disease (CHD). This randomized, double-blind, placebo-controlled trial was conducted and involved 60 people with overweight, diabetes, and CHD, aged 50-85 years old. Participants were randomly allocated into two groups to take either synbiotic supplements containing three probiotic bacteria spices Lactobacillus acidophilus strain T16 (IBRC-M10785), Lactobacillus casei strain T2 (IBRC-M10783), and Bifidobacterium bifidum strain T1 (IBRC-M10771) (2 × 109 CFU/g each) plus 800 mg inulin or placebo (n = 30 each group) for 12 weeks. Fasting blood samples were taken at baseline and after the 12-week intervention period to determine metabolic variables. After the 12-week intervention, compared with the placebo, synbiotic supplementation significantly reduced serum high-sensitivity C-reactive protein (hs-CRP) (- 3101.7 ± 5109.1 vs. - 6.2 ± 3163.6 ng/mL, P = 0.02), plasma malondialdehyde (MDA) (- 0.6 ± 1.0 vs. - 0.1 ± 0.3 μmol/L, P = 0.01), and significantly increased nitric oxide (NO) levels (+ 7.8 ± 10.3 vs. - 3.6 ± 6.9 μmol/L, P < 0.001). We did not observe any significant changes of synbiotic supplementation on other biomarkers of oxidative stress and CIMT levels. Overall, synbiotic supplementation for 12 weeks among people with overweight, diabetes, and CHD had beneficial effects on serum hs-CRP, plasma NO, and MDA levels; however, it did not have any effect on other biomarkers of oxidative stress and CIMT levels. SN - 1867-1314 UR - https://www.unboundmedicine.com/medline/citation/29079990/The_Effects_of_Synbiotic_Supplementation_on_Carotid_Intima_Media_Thickness_Biomarkers_of_Inflammation_and_Oxidative_Stress_in_People_with_Overweight_Diabetes_and_Coronary_Heart_Disease:_a_Randomized_Double_Blind_Placebo_Controlled_Trial_ L2 - https://dx.doi.org/10.1007/s12602-017-9343-1 DB - PRIME DP - Unbound Medicine ER -