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Neuroprotection through flavonoid: Enhancement of the glyoxalase pathway.
Redox Biol. 2018 04; 14:465-473.RB

Abstract

The glyoxalase pathway functions to detoxify reactive dicarbonyl compounds, most importantly methylglyoxal. The glyoxalase pathway is an antioxidant defense mechanism that is essential for neuroprotection. Excessive concentrations of methylglyoxal have deleterious effects on cells, leading to increased levels of inflammation and oxidative stress. Neurodegenerative diseases - including Alzheimer's, Parkinson's, Aging and Autism Spectrum Disorder - are often induced or exacerbated by accumulation of methylglyoxal. Antioxidant compounds possess several distinct mechanisms that enhance the glyoxalase pathway and function as neuroprotectants. Flavonoids are well-researched secondary plant metabolites that appear to be effective in reducing levels of oxidative stress and inflammation in neural cells. Novel flavonoids could be designed, synthesized and tested to protect against neurodegenerative diseases through regulating the glyoxalase pathway.

Authors+Show Affiliations

Department of Pathology and Microbiology, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5900, USA.Department of Pathology and Microbiology, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5900, USA. Electronic address: p.narayanasamy@unmc.edu.

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29080525

Citation

Frandsen, Joel R., and Prabagaran Narayanasamy. "Neuroprotection Through Flavonoid: Enhancement of the Glyoxalase Pathway." Redox Biology, vol. 14, 2018, pp. 465-473.
Frandsen JR, Narayanasamy P. Neuroprotection through flavonoid: Enhancement of the glyoxalase pathway. Redox Biol. 2018;14:465-473.
Frandsen, J. R., & Narayanasamy, P. (2018). Neuroprotection through flavonoid: Enhancement of the glyoxalase pathway. Redox Biology, 14, 465-473. https://doi.org/10.1016/j.redox.2017.10.015
Frandsen JR, Narayanasamy P. Neuroprotection Through Flavonoid: Enhancement of the Glyoxalase Pathway. Redox Biol. 2018;14:465-473. PubMed PMID: 29080525.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotection through flavonoid: Enhancement of the glyoxalase pathway. AU - Frandsen,Joel R, AU - Narayanasamy,Prabagaran, Y1 - 2017/10/18/ PY - 2017/09/20/received PY - 2017/10/11/revised PY - 2017/10/17/accepted PY - 2017/10/29/pubmed PY - 2018/7/17/medline PY - 2017/10/29/entrez KW - Antioxidant KW - Detoxification KW - Flavonoid KW - Glyoxalase pathway KW - Neurodegenerative disease KW - Neuron KW - Neurons viable KW - Neuroprotection SP - 465 EP - 473 JF - Redox biology JO - Redox Biol VL - 14 N2 - The glyoxalase pathway functions to detoxify reactive dicarbonyl compounds, most importantly methylglyoxal. The glyoxalase pathway is an antioxidant defense mechanism that is essential for neuroprotection. Excessive concentrations of methylglyoxal have deleterious effects on cells, leading to increased levels of inflammation and oxidative stress. Neurodegenerative diseases - including Alzheimer's, Parkinson's, Aging and Autism Spectrum Disorder - are often induced or exacerbated by accumulation of methylglyoxal. Antioxidant compounds possess several distinct mechanisms that enhance the glyoxalase pathway and function as neuroprotectants. Flavonoids are well-researched secondary plant metabolites that appear to be effective in reducing levels of oxidative stress and inflammation in neural cells. Novel flavonoids could be designed, synthesized and tested to protect against neurodegenerative diseases through regulating the glyoxalase pathway. SN - 2213-2317 UR - https://www.unboundmedicine.com/medline/citation/29080525/Neuroprotection_through_flavonoid:_Enhancement_of_the_glyoxalase_pathway_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2213-2317(17)30714-0 DB - PRIME DP - Unbound Medicine ER -