TY - JOUR T1 - Role of Diet and Nutritional Supplements in Parkinson's Disease Progression. AU - Mischley,Laurie K, AU - Lau,Richard C, AU - Bennett,Rachel D, Y1 - 2017/09/10/ PY - 2017/04/11/received PY - 2017/07/19/revised PY - 2017/07/30/accepted PY - 2017/10/31/entrez PY - 2017/10/31/pubmed PY - 2018/7/3/medline SP - 6405278 EP - 6405278 JF - Oxidative medicine and cellular longevity JO - Oxid Med Cell Longev VL - 2017 N2 - OBJECTIVES: The goal of this study is to describe modifiable lifestyle variables associated with reduced rate of Parkinson's disease (PD) progression. METHODS: The patient-reported outcomes in PD (PRO-PD) were used as the primary outcome measure, and a food frequency questionnaire (FFQ) was used to assess dietary intake. In this cross-sectional analysis, regression analysis was performed on baseline data to identify the nutritional and pharmacological interventions associated with the rate of PD progression. All analyses were adjusted for age, gender, and years since diagnosis. RESULTS: 1053 individuals with self-reported idiopathic PD were available for analysis. Foods associated with the reduced rate of PD progression included fresh vegetables, fresh fruit, nuts and seeds, nonfried fish, olive oil, wine, coconut oil, fresh herbs, and spices (P < 0.05). Foods associated with more rapid PD progression include canned fruits and vegetables, diet and nondiet soda, fried foods, beef, ice cream, yogurt, and cheese (P < 0.05). Nutritional supplements coenzyme Q10 and fish oil were associated with reduced PD progression (P = 0.026 and P = 0.019, resp.), and iron supplementation was associated with faster progression (P = 0.022). DISCUSSION: These are the first data to provide evidence that targeted nutrition is associated with the rate of PD progression. SN - 1942-0994 UR - https://www.unboundmedicine.com/medline/citation/29081890/full_citation DB - PRIME DP - Unbound Medicine ER -