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Immunoreactive prolactin in breast milk and plasma of women with hyperprolactinemia, galactorrhea and menstrual dysfunction.
Int J Fertil. 1986 Mar-Apr; 31(1):67-70.IJ

Abstract

Prolactin levels were measured by radioimmunoassay in paired breast milk and plasma samples of 11 hyperprolactinemic women with galactorrhea and various menstrual disorders (amenorrhea, n = 8; oligomenorrhea, n = 2; luteal phase defect, n = 1) before and during treatment with bromocriptine (Parlodel, Sandoz). Pretreatment levels of prolactin in the milk and plasma were 80 +/- 13 ng/mL (mean +/- SEM) and 47 +/- 7 ng/mL (P less than 0.05), respectively. While on treatment, the concentration gradient for prolactin remained in favour of the milk, with values for milk and plasma 59 +/- 11 and 29 +/- 3 ng/mL (P less than 0.01), respectively. Thus, bromocriptine lowered the prolactin concentrations in both breast milk and plasma. Since prolactin in milk is biologically active, these findings may be relevant to the initiation and maintenance of lactation in women with abnormal lactogenesis.

Authors+Show Affiliations

Department of Obstetrics and Gynaecology, Faculty of Medicine, University of British Columbia, Vancouver, Canada.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2908279

Citation

Yuen, B H.. "Immunoreactive Prolactin in Breast Milk and Plasma of Women With Hyperprolactinemia, Galactorrhea and Menstrual Dysfunction." International Journal of Fertility, vol. 31, no. 1, 1986, pp. 67-70.
Yuen BH. Immunoreactive prolactin in breast milk and plasma of women with hyperprolactinemia, galactorrhea and menstrual dysfunction. Int J Fertil. 1986;31(1):67-70.
Yuen, B. H. (1986). Immunoreactive prolactin in breast milk and plasma of women with hyperprolactinemia, galactorrhea and menstrual dysfunction. International Journal of Fertility, 31(1), 67-70.
Yuen BH. Immunoreactive Prolactin in Breast Milk and Plasma of Women With Hyperprolactinemia, Galactorrhea and Menstrual Dysfunction. Int J Fertil. 1986 Mar-Apr;31(1):67-70. PubMed PMID: 2908279.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunoreactive prolactin in breast milk and plasma of women with hyperprolactinemia, galactorrhea and menstrual dysfunction. A1 - Yuen,B H, PY - 1986/3/1/pubmed PY - 1986/3/1/medline PY - 1986/3/1/entrez SP - 67 EP - 70 JF - International journal of fertility JO - Int J Fertil VL - 31 IS - 1 N2 - Prolactin levels were measured by radioimmunoassay in paired breast milk and plasma samples of 11 hyperprolactinemic women with galactorrhea and various menstrual disorders (amenorrhea, n = 8; oligomenorrhea, n = 2; luteal phase defect, n = 1) before and during treatment with bromocriptine (Parlodel, Sandoz). Pretreatment levels of prolactin in the milk and plasma were 80 +/- 13 ng/mL (mean +/- SEM) and 47 +/- 7 ng/mL (P less than 0.05), respectively. While on treatment, the concentration gradient for prolactin remained in favour of the milk, with values for milk and plasma 59 +/- 11 and 29 +/- 3 ng/mL (P less than 0.01), respectively. Thus, bromocriptine lowered the prolactin concentrations in both breast milk and plasma. Since prolactin in milk is biologically active, these findings may be relevant to the initiation and maintenance of lactation in women with abnormal lactogenesis. SN - 0020-725X UR - https://www.unboundmedicine.com/medline/citation/2908279/Immunoreactive_prolactin_in_breast_milk_and_plasma_of_women_with_hyperprolactinemia_galactorrhea_and_menstrual_dysfunction_ L2 - http://www.diseaseinfosearch.org/result/2971 DB - PRIME DP - Unbound Medicine ER -