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Somatostatin-like immunoreactivity and somatostatin receptor binding in rat brain in pentylenetetrazol-induced kindling.
Peptides. 1988; 9 Suppl 1:105-7.P

Abstract

Kindling was induced in Sprague-Dawley rats by repeated injection of pentylenetetrazol (PTZ, 30 mg/kg, IP). Somatostatin-like immunoreactivity (SLI) and 125I-Tyr-somatostatin binding were measured in different areas of the brain in saline-injected controls, rats receiving PTZ but not kindled (prekindled rats), and kindled rats. Compared to SLI levels in controls, SLI increased (p < 0.01) in the frontal cortex, striatum (p < 0.05 in kindled rats), and hippocampus of both prekindled and kindled animals. Hypothalamic levels of SLI remained unchanged. Compared with the controls, no change was found in somatostatin receptor binding in the frontal cortex, striatum or hippocampus in prekindled or kindled animals. These results suggest that an increased level of somatostatin may be connected to the development and maintenance of kindling.

Authors+Show Affiliations

Pitkänen A
Department of Neurology, University of Kuopio, Finland.
Jolkkonen J
No affiliation info available
Sirviö J
No affiliation info available
Riekkinen P
No affiliation info available

MeSH

AnimalsBrainKindling, NeurologicMalePentylenetetrazolePeptidesRatsRats, Sprague-DawleyReceptors, SomatostatinSomatostatin

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2908807

Citation

Pitkänen, A, et al. "Somatostatin-like Immunoreactivity and Somatostatin Receptor Binding in Rat Brain in Pentylenetetrazol-induced Kindling." Peptides, vol. 9 Suppl 1, 1988, pp. 105-7.
Pitkänen A, Jolkkonen J, Sirviö J, et al. Somatostatin-like immunoreactivity and somatostatin receptor binding in rat brain in pentylenetetrazol-induced kindling. Peptides. 1988;9 Suppl 1:105-7.
Pitkänen, A., Jolkkonen, J., Sirviö, J., & Riekkinen, P. (1988). Somatostatin-like immunoreactivity and somatostatin receptor binding in rat brain in pentylenetetrazol-induced kindling. Peptides, 9 Suppl 1, 105-7.
Pitkänen A, et al. Somatostatin-like Immunoreactivity and Somatostatin Receptor Binding in Rat Brain in Pentylenetetrazol-induced Kindling. Peptides. 1988;9 Suppl 1:105-7. PubMed PMID: 2908807.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Somatostatin-like immunoreactivity and somatostatin receptor binding in rat brain in pentylenetetrazol-induced kindling. AU - Pitkänen,A, AU - Jolkkonen,J, AU - Sirviö,J, AU - Riekkinen,P, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez SP - 105 EP - 7 JF - Peptides JO - Peptides VL - 9 Suppl 1 N2 - Kindling was induced in Sprague-Dawley rats by repeated injection of pentylenetetrazol (PTZ, 30 mg/kg, IP). Somatostatin-like immunoreactivity (SLI) and 125I-Tyr-somatostatin binding were measured in different areas of the brain in saline-injected controls, rats receiving PTZ but not kindled (prekindled rats), and kindled rats. Compared to SLI levels in controls, SLI increased (p < 0.01) in the frontal cortex, striatum (p < 0.05 in kindled rats), and hippocampus of both prekindled and kindled animals. Hypothalamic levels of SLI remained unchanged. Compared with the controls, no change was found in somatostatin receptor binding in the frontal cortex, striatum or hippocampus in prekindled or kindled animals. These results suggest that an increased level of somatostatin may be connected to the development and maintenance of kindling. SN - 0196-9781 UR - https://www.unboundmedicine.com/medline/citation/2908807/Somatostatin_like_immunoreactivity_and_somatostatin_receptor_binding_in_rat_brain_in_pentylenetetrazol_induced_kindling_ DB - PRIME DP - Unbound Medicine ER -