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Multiple epidermolytic acanthomas mimicking condyloma: a retrospective study of 8 cases.
Int J Dermatol. 2018 Jan; 57(1):28-33.IJ

Abstract

BACKGROUND

Epidermolytic acanthoma (EA) is an uncommon benign cutaneous lesion. Multiple epidermolytic acanthomas (multiple EAs) are rarely reported.

METHODS

We retrospectively identified patients diagnosed with multiple EAs between 2005 and 2017 from our dermatopathology database and analyzed their clinical, pathological, and immunohistochemical features. We also evaluated the association of multiple EAs with human papillomavirus (HPV) infection.

RESULTS

In total, eight patients (average age 51 years; 3 : 1 male predominance) with multiple EAs were found. All patients had lesions on the genitocrural area. The two most common clinical diagnoses were condyloma (5/8) and soft fibroma (3/8), which were predominantly skin-colored (5/8) or whitish (2/8). The lesions were less than 1 cm in diameter, and most (6/8) appeared to have a smooth surface. No molecular evidence suggesting HPV infection was found. Immunohistochemical staining showed low mitotic activity. The lesions were removed in one of two patients via cryotherapy, and one patient was treated with electrocauterization. The other five patients were followed without treatment.

CONCLUSION

The genital area was the most common location for multiple EAs, which was commonly misdiagnosed clinically as condyloma. Patients presenting with uniformly small-sized, skin-colored to whitish, smooth papular lesions in the genitalia should be carefully evaluated. The specific pathological features of epidermolytic hyperkeratosis are diagnostic, and the lesions can be observed without aggressive treatment after confirmed diagnosis.

Authors+Show Affiliations

Department of Dermatology, Mackay Memorial Hospital, Taipei, Taiwan.Department of Dermatology, Mackay Memorial Hospital, Taipei, Taiwan. Department of Medicine, Mackay Medical College, New Taipei City, Taiwan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29090469

Citation

Lee, Tsung-Ju, and Yu-Hung Wu. "Multiple Epidermolytic Acanthomas Mimicking Condyloma: a Retrospective Study of 8 Cases." International Journal of Dermatology, vol. 57, no. 1, 2018, pp. 28-33.
Lee TJ, Wu YH. Multiple epidermolytic acanthomas mimicking condyloma: a retrospective study of 8 cases. Int J Dermatol. 2018;57(1):28-33.
Lee, T. J., & Wu, Y. H. (2018). Multiple epidermolytic acanthomas mimicking condyloma: a retrospective study of 8 cases. International Journal of Dermatology, 57(1), 28-33. https://doi.org/10.1111/ijd.13818
Lee TJ, Wu YH. Multiple Epidermolytic Acanthomas Mimicking Condyloma: a Retrospective Study of 8 Cases. Int J Dermatol. 2018;57(1):28-33. PubMed PMID: 29090469.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multiple epidermolytic acanthomas mimicking condyloma: a retrospective study of 8 cases. AU - Lee,Tsung-Ju, AU - Wu,Yu-Hung, Y1 - 2017/10/31/ PY - 2017/08/14/received PY - 2017/09/20/revised PY - 2017/09/26/accepted PY - 2017/11/2/pubmed PY - 2018/8/8/medline PY - 2017/11/2/entrez SP - 28 EP - 33 JF - International journal of dermatology JO - Int. J. Dermatol. VL - 57 IS - 1 N2 - BACKGROUND: Epidermolytic acanthoma (EA) is an uncommon benign cutaneous lesion. Multiple epidermolytic acanthomas (multiple EAs) are rarely reported. METHODS: We retrospectively identified patients diagnosed with multiple EAs between 2005 and 2017 from our dermatopathology database and analyzed their clinical, pathological, and immunohistochemical features. We also evaluated the association of multiple EAs with human papillomavirus (HPV) infection. RESULTS: In total, eight patients (average age 51 years; 3 : 1 male predominance) with multiple EAs were found. All patients had lesions on the genitocrural area. The two most common clinical diagnoses were condyloma (5/8) and soft fibroma (3/8), which were predominantly skin-colored (5/8) or whitish (2/8). The lesions were less than 1 cm in diameter, and most (6/8) appeared to have a smooth surface. No molecular evidence suggesting HPV infection was found. Immunohistochemical staining showed low mitotic activity. The lesions were removed in one of two patients via cryotherapy, and one patient was treated with electrocauterization. The other five patients were followed without treatment. CONCLUSION: The genital area was the most common location for multiple EAs, which was commonly misdiagnosed clinically as condyloma. Patients presenting with uniformly small-sized, skin-colored to whitish, smooth papular lesions in the genitalia should be carefully evaluated. The specific pathological features of epidermolytic hyperkeratosis are diagnostic, and the lesions can be observed without aggressive treatment after confirmed diagnosis. SN - 1365-4632 UR - https://www.unboundmedicine.com/medline/citation/29090469/Multiple_epidermolytic_acanthomas_mimicking_condyloma:_a_retrospective_study_of_8_cases_ L2 - https://doi.org/10.1111/ijd.13818 DB - PRIME DP - Unbound Medicine ER -