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[Preliminary analysis on relationship between traditional efficacy of Chinese medicine and modern pharmacological action].
Zhongguo Zhong Yao Za Zhi 2017; 42(10):1979-1983ZZ

Abstract

To find the relationship between traditional efficacy of Chinese medicine and modern pharmacological action by using data mining, and provide information and reference for further research and development for the pharmacology research of traditional Chinese medicine.The information of 547 kinds of traditional Chinese medicines, 335 kinds of Chinese medicine effects and 86 kinds of pharmacological actions were collected and processed in Clinical Guide to the Chinese Pharmacopoeia published in 2010; Access and Excel software were used to analyze the frequence and frequency of single effect, pharmacological action, and both. In addition, the relationship between efficacy and pharmacology was analyzed with the clearing heat and antibacterial effects as the example. The analysis results showed that 547 kinds of Chinese medicines involved 335 kinds of Chinese medicine effects and 86 kinds of pharmacological actions. Among them, the most frequent Chinese medicine effect was"clearing heat", whose frequence was 130 and the frequency was 0.24; the most frequent pharmacological action was "anti-inflammatory action" whose frequence was 191 and the frequency was 0.35. The most common efficacy-pharmacological action group was "clearing heat" and "anti-bacterial action", whose frequence was 75 and the frequency was 0.26. The couple of "purgation" and "cathartic effect" had the largest frequency of 0.30, but they just appeared together for 3 times. There were 52 kinds of pharmacological actions that occurred together with clearing heat, of which, the top 10 were anti-bacterial action, anti-inflammatory action, antineoplastic action, anti-hepatic injury action, immunoregulation action, antipyretic action, antiviralaction, hypoglycemic action, antioxidant action and analgesic action. There were 161 kinds of Chinese medicine effects that occurred together with anti-bacterial action, of which, the top 10 were clearing heat, detoxification, detumescence, analgesia, resolving dampness, pesticide, cooling blood, expelling wind, eliminating dampness and hemostasis. These results suggested that there was a certain relationship between traditional Chinese medicine effects and modern pharmacological actions.

Authors+Show Affiliations

Beijing Key Laboratory of Pharmacology of Traditional Chinese Medicine, Institute of Basic Medical Sciences of Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.Beijing Key Laboratory of Pharmacology of Traditional Chinese Medicine, Institute of Basic Medical Sciences of Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.Beijing Key Laboratory of Pharmacology of Traditional Chinese Medicine, Institute of Basic Medical Sciences of Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.

Pub Type(s)

Journal Article

Language

chi

PubMed ID

29090560

Citation

Ren, Jun-Guo, et al. "[Preliminary Analysis On Relationship Between Traditional Efficacy of Chinese Medicine and Modern Pharmacological Action]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 42, no. 10, 2017, pp. 1979-1983.
Ren JG, Wang DZ, Lei L, et al. [Preliminary analysis on relationship between traditional efficacy of Chinese medicine and modern pharmacological action]. Zhongguo Zhong Yao Za Zhi. 2017;42(10):1979-1983.
Ren, J. G., Wang, D. Z., Lei, L., Kang, L., & Liu, J. X. (2017). [Preliminary analysis on relationship between traditional efficacy of Chinese medicine and modern pharmacological action]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 42(10), pp. 1979-1983. doi:10.19540/j.cnki.cjcmm.20170307.002.
Ren JG, et al. [Preliminary Analysis On Relationship Between Traditional Efficacy of Chinese Medicine and Modern Pharmacological Action]. Zhongguo Zhong Yao Za Zhi. 2017;42(10):1979-1983. PubMed PMID: 29090560.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Preliminary analysis on relationship between traditional efficacy of Chinese medicine and modern pharmacological action]. AU - Ren,Jun-Guo, AU - Wang,Dong-Zhi, AU - Lei,Lei, AU - Kang,Li, AU - Liu,Jian-Xun, PY - 2016/11/22/received PY - 2017/11/2/entrez PY - 2017/11/2/pubmed PY - 2019/4/16/medline KW - anti-bacterial action KW - clearing heat KW - pharmacological action KW - traditional Chinese medicine KW - traditional efficacy SP - 1979 EP - 1983 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 42 IS - 10 N2 - To find the relationship between traditional efficacy of Chinese medicine and modern pharmacological action by using data mining, and provide information and reference for further research and development for the pharmacology research of traditional Chinese medicine.The information of 547 kinds of traditional Chinese medicines, 335 kinds of Chinese medicine effects and 86 kinds of pharmacological actions were collected and processed in Clinical Guide to the Chinese Pharmacopoeia published in 2010; Access and Excel software were used to analyze the frequence and frequency of single effect, pharmacological action, and both. In addition, the relationship between efficacy and pharmacology was analyzed with the clearing heat and antibacterial effects as the example. The analysis results showed that 547 kinds of Chinese medicines involved 335 kinds of Chinese medicine effects and 86 kinds of pharmacological actions. Among them, the most frequent Chinese medicine effect was"clearing heat", whose frequence was 130 and the frequency was 0.24; the most frequent pharmacological action was "anti-inflammatory action" whose frequence was 191 and the frequency was 0.35. The most common efficacy-pharmacological action group was "clearing heat" and "anti-bacterial action", whose frequence was 75 and the frequency was 0.26. The couple of "purgation" and "cathartic effect" had the largest frequency of 0.30, but they just appeared together for 3 times. There were 52 kinds of pharmacological actions that occurred together with clearing heat, of which, the top 10 were anti-bacterial action, anti-inflammatory action, antineoplastic action, anti-hepatic injury action, immunoregulation action, antipyretic action, antiviralaction, hypoglycemic action, antioxidant action and analgesic action. There were 161 kinds of Chinese medicine effects that occurred together with anti-bacterial action, of which, the top 10 were clearing heat, detoxification, detumescence, analgesia, resolving dampness, pesticide, cooling blood, expelling wind, eliminating dampness and hemostasis. These results suggested that there was a certain relationship between traditional Chinese medicine effects and modern pharmacological actions. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/29090560/[Preliminary_analysis_on_relationship_between_traditional_efficacy_of_Chinese_medicine_and_modern_pharmacological_action] DB - PRIME DP - Unbound Medicine ER -