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Thickness mapping of individual retinal layers and sectors by Spectralis SD-OCT in Autosomal Dominant Optic Atrophy.
Acta Ophthalmol. 2018 May; 96(3):251-256.AO

Abstract

PURPOSE

To assess layer- and location-specific retinal thickness deficits in autosomal dominant optic atrophy (ADOA) using Spectralis SD-OCT.

METHODS

This cross-sectional study included 41 ADOA patients with OPA1 exon 28 (2826delT) mutation [age, 8.6-83.5 years; best-corrected visual acuity (BCVA), 8-89 Early Treatment Diabetic Retinopathy Study (ETDRS) letters] and 55 mutation-free first-degree relatives as healthy controls (age, 8.9-68.7; BCVA, 80-99). Participants underwent routine examination and optical coherence tomography (OCT) with segmentation of the whole retina, inner retinal layers (IRL) and outer retinal layers (ORL). Individual segmentation was performed of the perifoveal retinal nerve fibre layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), retinal pigment epithelium (RPE) and the peripapillary RNFL. Combinations of layers and sectors were tested for their diagnostic significance. Only right eye data are presented. Statistical analysis was adjusted for age, gender, spherical equivalent, axial length and family clustering in a mixed model analysis.

RESULTS

The perifoveal RNFL, GCL, IPL and the peripapillary RNFL were all significantly thinner in ADOA patients than in healthy controls (p < 0.0001). No statistical difference was found for other layers. The most prominent and diagnostically most valuable deficit was found in the GCL (-49.9%) in the 'nasal inner macula' (NIM) sector (-63%). Attenuation of the peripapillary RNFL was most significant in the temporal sector (-58.4%).

CONCLUSION

In ADOA, retinal ganglion cells are most prominently reduced in the nasal perifoveal area of the GCL, which together with the temporal peripapillary RNFL area serves as the strongest diagnostic OCT marker.

Authors+Show Affiliations

Department of Ophthalmology, Glostrup Hospital, Copenhagen, Denmark.Department of Ophthalmology, Glostrup Hospital, Copenhagen, Denmark.Department of Ophthalmology, Glostrup Hospital, Copenhagen, Denmark.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

29091347

Citation

Corajevic, Nihada, et al. "Thickness Mapping of Individual Retinal Layers and Sectors By Spectralis SD-OCT in Autosomal Dominant Optic Atrophy." Acta Ophthalmologica, vol. 96, no. 3, 2018, pp. 251-256.
Corajevic N, Larsen M, Rönnbäck C. Thickness mapping of individual retinal layers and sectors by Spectralis SD-OCT in Autosomal Dominant Optic Atrophy. Acta Ophthalmol. 2018;96(3):251-256.
Corajevic, N., Larsen, M., & Rönnbäck, C. (2018). Thickness mapping of individual retinal layers and sectors by Spectralis SD-OCT in Autosomal Dominant Optic Atrophy. Acta Ophthalmologica, 96(3), 251-256. https://doi.org/10.1111/aos.13588
Corajevic N, Larsen M, Rönnbäck C. Thickness Mapping of Individual Retinal Layers and Sectors By Spectralis SD-OCT in Autosomal Dominant Optic Atrophy. Acta Ophthalmol. 2018;96(3):251-256. PubMed PMID: 29091347.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thickness mapping of individual retinal layers and sectors by Spectralis SD-OCT in Autosomal Dominant Optic Atrophy. AU - Corajevic,Nihada, AU - Larsen,Michael, AU - Rönnbäck,Cecilia, Y1 - 2017/11/01/ PY - 2017/06/11/received PY - 2017/08/11/accepted PY - 2017/11/2/pubmed PY - 2018/7/18/medline PY - 2017/11/2/entrez KW - Spectralis OCT KW - autosomal dominant optic atrophy KW - nasal inner macula KW - the ganglion cell layer SP - 251 EP - 256 JF - Acta ophthalmologica JO - Acta Ophthalmol VL - 96 IS - 3 N2 - PURPOSE: To assess layer- and location-specific retinal thickness deficits in autosomal dominant optic atrophy (ADOA) using Spectralis SD-OCT. METHODS: This cross-sectional study included 41 ADOA patients with OPA1 exon 28 (2826delT) mutation [age, 8.6-83.5 years; best-corrected visual acuity (BCVA), 8-89 Early Treatment Diabetic Retinopathy Study (ETDRS) letters] and 55 mutation-free first-degree relatives as healthy controls (age, 8.9-68.7; BCVA, 80-99). Participants underwent routine examination and optical coherence tomography (OCT) with segmentation of the whole retina, inner retinal layers (IRL) and outer retinal layers (ORL). Individual segmentation was performed of the perifoveal retinal nerve fibre layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), retinal pigment epithelium (RPE) and the peripapillary RNFL. Combinations of layers and sectors were tested for their diagnostic significance. Only right eye data are presented. Statistical analysis was adjusted for age, gender, spherical equivalent, axial length and family clustering in a mixed model analysis. RESULTS: The perifoveal RNFL, GCL, IPL and the peripapillary RNFL were all significantly thinner in ADOA patients than in healthy controls (p < 0.0001). No statistical difference was found for other layers. The most prominent and diagnostically most valuable deficit was found in the GCL (-49.9%) in the 'nasal inner macula' (NIM) sector (-63%). Attenuation of the peripapillary RNFL was most significant in the temporal sector (-58.4%). CONCLUSION: In ADOA, retinal ganglion cells are most prominently reduced in the nasal perifoveal area of the GCL, which together with the temporal peripapillary RNFL area serves as the strongest diagnostic OCT marker. SN - 1755-3768 UR - https://www.unboundmedicine.com/medline/citation/29091347/Thickness_mapping_of_individual_retinal_layers_and_sectors_by_Spectralis_SD_OCT_in_Autosomal_Dominant_Optic_Atrophy_ L2 - https://doi.org/10.1111/aos.13588 DB - PRIME DP - Unbound Medicine ER -