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Inhibition of 3,5,2',4'-Tetrahydroxychalcone on Production of Uric Acid in Hypoxanthine-Induced Hyperuricemic Mice.
Biol Pharm Bull. 2018 Jan 01; 41(1):99-105.BP

Abstract

The mechanism of 3,5,2',4'-tetrahydroxychalcone on lowing urate level is still unknown. Here we investigated the effects of 3,5,2',4'-tetrahydroxychalcone on urate levels, xanthine oxidase/xanthine dehydrogenase (XOD/XDH) activities in hypoxanthine-induced hyperuricemic mice, as well as the effects of 3,5,2',4'-tetrahydroxychalcone on the mRNA expression levels and content of phosphoribosyl pyrophosphate synthetase (PRPS), phosphoribosyl pyrophosphate amidotransferase (PRPPAT) and hypoxanthine-guanine phosphoribosyl transferase (HGPRT). Our results demonstrated that 3,5,2',4'-tetrahydroxychalcone (1.0, 2.0, and 4.0 mg/kg) reduced the uric acid levels in serum of the hyperuricemic mice in dose- and time-dependent manners. The activities of XOD/XDH in serum and liver were also significantly inhibited by 3,5,2',4'-tetrahydroxychalcone; In addition, 3,5,2',4'-tetrahydroxychalcone decreased the mRNA expression of HGPRT in brain and content of PRPS and PRPPAT in liver. These findings demonstrated that 3,5,2',4'-tetrahydroxychalcone suppresses uric acid production by affecting the critical enzymes, XOD/XDH, PRPS, PRPPAT and HGPRT in purine nucleotide metabolism.

Authors+Show Affiliations

State Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University. Biomedical Engineering Research Center, Kunming Medical University. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences. University of Chinese Academy of Sciences.Biomedical Engineering Research Center, Kunming Medical University. The Second Affiliated Hospital of Kunming Medical University.Biomedical Engineering Research Center, Kunming Medical University.Biomedical Engineering Research Center, Kunming Medical University.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences.College of Pharmacy, HeiBei University.State Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University.Biomedical Engineering Research Center, Kunming Medical University.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29093325

Citation

Niu, Yanfen, et al. "Inhibition of 3,5,2',4'-Tetrahydroxychalcone On Production of Uric Acid in Hypoxanthine-Induced Hyperuricemic Mice." Biological & Pharmaceutical Bulletin, vol. 41, no. 1, 2018, pp. 99-105.
Niu Y, Zhou Y, Lin H, et al. Inhibition of 3,5,2',4'-Tetrahydroxychalcone on Production of Uric Acid in Hypoxanthine-Induced Hyperuricemic Mice. Biol Pharm Bull. 2018;41(1):99-105.
Niu, Y., Zhou, Y., Lin, H., Gao, L. H., Xiong, W., Zhu, H., Zou, C. G., & Li, L. (2018). Inhibition of 3,5,2',4'-Tetrahydroxychalcone on Production of Uric Acid in Hypoxanthine-Induced Hyperuricemic Mice. Biological & Pharmaceutical Bulletin, 41(1), 99-105. https://doi.org/10.1248/bpb.b17-00655
Niu Y, et al. Inhibition of 3,5,2',4'-Tetrahydroxychalcone On Production of Uric Acid in Hypoxanthine-Induced Hyperuricemic Mice. Biol Pharm Bull. 2018 Jan 1;41(1):99-105. PubMed PMID: 29093325.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibition of 3,5,2',4'-Tetrahydroxychalcone on Production of Uric Acid in Hypoxanthine-Induced Hyperuricemic Mice. AU - Niu,Yanfen, AU - Zhou,Yuanfang, AU - Lin,Hua, AU - Gao,Li-Hui, AU - Xiong,Wenyong, AU - Zhu,Huajie, AU - Zou,Cheng-Gang, AU - Li,Ling, Y1 - 2017/11/01/ PY - 2017/11/3/pubmed PY - 2018/8/7/medline PY - 2017/11/3/entrez KW - 3,5,2′,4′-tetrahydroxychalcone KW - hyperuricemia KW - purine metabolism enzyme SP - 99 EP - 105 JF - Biological & pharmaceutical bulletin JO - Biol. Pharm. Bull. VL - 41 IS - 1 N2 - The mechanism of 3,5,2',4'-tetrahydroxychalcone on lowing urate level is still unknown. Here we investigated the effects of 3,5,2',4'-tetrahydroxychalcone on urate levels, xanthine oxidase/xanthine dehydrogenase (XOD/XDH) activities in hypoxanthine-induced hyperuricemic mice, as well as the effects of 3,5,2',4'-tetrahydroxychalcone on the mRNA expression levels and content of phosphoribosyl pyrophosphate synthetase (PRPS), phosphoribosyl pyrophosphate amidotransferase (PRPPAT) and hypoxanthine-guanine phosphoribosyl transferase (HGPRT). Our results demonstrated that 3,5,2',4'-tetrahydroxychalcone (1.0, 2.0, and 4.0 mg/kg) reduced the uric acid levels in serum of the hyperuricemic mice in dose- and time-dependent manners. The activities of XOD/XDH in serum and liver were also significantly inhibited by 3,5,2',4'-tetrahydroxychalcone; In addition, 3,5,2',4'-tetrahydroxychalcone decreased the mRNA expression of HGPRT in brain and content of PRPS and PRPPAT in liver. These findings demonstrated that 3,5,2',4'-tetrahydroxychalcone suppresses uric acid production by affecting the critical enzymes, XOD/XDH, PRPS, PRPPAT and HGPRT in purine nucleotide metabolism. SN - 1347-5215 UR - https://www.unboundmedicine.com/medline/citation/29093325/Inhibition_of_352'4'_Tetrahydroxychalcone_on_Production_of_Uric_Acid_in_Hypoxanthine_Induced_Hyperuricemic_Mice_ L2 - https://dx.doi.org/10.1248/bpb.b17-00655 DB - PRIME DP - Unbound Medicine ER -