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Association between Antihypertensive Drug Use and the Incidence of Cognitive Decline and Dementia: A Meta-Analysis of Prospective Cohort Studies.
Biomed Res Int 2017; 2017:4368474BR

Abstract

Background

Antihypertensive drug use is inconsistently associated with the risk of dementia, Alzheimer's disease, cognitive impairment, and cognitive decline. Therefore, we conducted a meta-analysis of available prospective cohort studies to summarize the evidence on the strength of these relationships.

Methods

Three electronic databases including MedLine, Embase, and the Cochrane Library were searched to identify studies from inception to April 2017. Only prospective cohort studies that reported effect estimates with corresponding 95% confidence intervals (CIs) of dementia, Alzheimer's disease, cognitive impairment, and cognitive decline for antihypertensive drug use versus not using antihypertensive drugs were included.

Results

We included 10 prospective cohort studies reporting data on 30,895 individuals. Overall, participants who received antihypertensive drugs had lower incidence of dementia (relative risk [RR]: 0.86; 95% CI: 0.75-0.99; p = 0.033), while there was no significant effect on the incidence of Alzheimer's disease (RR: 0.83; 95% CI: 0.64-1.09; p = 0.154), cognitive impairment (RR: 0.89; 95% CI: 0.57-1.38; p = 0.596), and cognitive decline (RR: 1.11; 95% CI: 0.86-1.43; p = 0.415). Further, the incidence of Alzheimer's disease might be affected by antihypertensive drug use in participants with specific characteristics.

Conclusions

Antihypertensive drug use was associated with a significantly reduced risk of dementia, but not with the risk of Alzheimer's disease, cognitive impairment, and cognitive decline.

Authors+Show Affiliations

Department of Cardiology, Lanzhou University Second Hospital, Lanzhou 730030, China.Department of Cardiology, Lanzhou University Second Hospital, Lanzhou 730030, China.Department of Cardiology, Lanzhou University Second Hospital, Lanzhou 730030, China.Department of Cardiology, Lanzhou University Second Hospital, Lanzhou 730030, China.Department of Cardiology, Lanzhou University Second Hospital, Lanzhou 730030, China.Department of Cardiology, Lanzhou University Second Hospital, Lanzhou 730030, China.Department of Cardiology, Lanzhou University Second Hospital, Lanzhou 730030, China.Department of Urology, Lanzhou University Second Hospital, Lanzhou 730030, China.Department of Cardiac Surgery, Lanzhou University Second Hospital, Lanzhou 730030, China.

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

29094046

Citation

Xu, Guangli, et al. "Association Between Antihypertensive Drug Use and the Incidence of Cognitive Decline and Dementia: a Meta-Analysis of Prospective Cohort Studies." BioMed Research International, vol. 2017, 2017, p. 4368474.
Xu G, Bai F, Lin X, et al. Association between Antihypertensive Drug Use and the Incidence of Cognitive Decline and Dementia: A Meta-Analysis of Prospective Cohort Studies. Biomed Res Int. 2017;2017:4368474.
Xu, G., Bai, F., Lin, X., Wang, Q., Wu, Q., Sun, S., ... Gao, B. (2017). Association between Antihypertensive Drug Use and the Incidence of Cognitive Decline and Dementia: A Meta-Analysis of Prospective Cohort Studies. BioMed Research International, 2017, p. 4368474. doi:10.1155/2017/4368474.
Xu G, et al. Association Between Antihypertensive Drug Use and the Incidence of Cognitive Decline and Dementia: a Meta-Analysis of Prospective Cohort Studies. Biomed Res Int. 2017;2017:4368474. PubMed PMID: 29094046.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between Antihypertensive Drug Use and the Incidence of Cognitive Decline and Dementia: A Meta-Analysis of Prospective Cohort Studies. AU - Xu,Guangli, AU - Bai,Feng, AU - Lin,Xin, AU - Wang,Qiongying, AU - Wu,Qiang, AU - Sun,Shougang, AU - Jiang,Cheng, AU - Liang,Qiang, AU - Gao,Bingren, Y1 - 2017/09/28/ PY - 2017/05/08/received PY - 2017/06/28/revised PY - 2017/07/27/accepted PY - 2017/11/3/entrez PY - 2017/11/3/pubmed PY - 2018/6/16/medline SP - 4368474 EP - 4368474 JF - BioMed research international JO - Biomed Res Int VL - 2017 N2 - Background: Antihypertensive drug use is inconsistently associated with the risk of dementia, Alzheimer's disease, cognitive impairment, and cognitive decline. Therefore, we conducted a meta-analysis of available prospective cohort studies to summarize the evidence on the strength of these relationships. Methods: Three electronic databases including MedLine, Embase, and the Cochrane Library were searched to identify studies from inception to April 2017. Only prospective cohort studies that reported effect estimates with corresponding 95% confidence intervals (CIs) of dementia, Alzheimer's disease, cognitive impairment, and cognitive decline for antihypertensive drug use versus not using antihypertensive drugs were included. Results: We included 10 prospective cohort studies reporting data on 30,895 individuals. Overall, participants who received antihypertensive drugs had lower incidence of dementia (relative risk [RR]: 0.86; 95% CI: 0.75-0.99; p = 0.033), while there was no significant effect on the incidence of Alzheimer's disease (RR: 0.83; 95% CI: 0.64-1.09; p = 0.154), cognitive impairment (RR: 0.89; 95% CI: 0.57-1.38; p = 0.596), and cognitive decline (RR: 1.11; 95% CI: 0.86-1.43; p = 0.415). Further, the incidence of Alzheimer's disease might be affected by antihypertensive drug use in participants with specific characteristics. Conclusions: Antihypertensive drug use was associated with a significantly reduced risk of dementia, but not with the risk of Alzheimer's disease, cognitive impairment, and cognitive decline. SN - 2314-6141 UR - https://www.unboundmedicine.com/medline/citation/29094046/Association_between_Antihypertensive_Drug_Use_and_the_Incidence_of_Cognitive_Decline_and_Dementia:_A_Meta_Analysis_of_Prospective_Cohort_Studies_ L2 - https://dx.doi.org/10.1155/2017/4368474 DB - PRIME DP - Unbound Medicine ER -