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Body-fat indicators and kidney function decline in older post-myocardial infarction patients: The Alpha Omega Cohort Study.
Eur J Prev Cardiol 2018; 25(1):90-99EJ

Abstract

Background Obesity increases risk of hypertension and diabetes, the leading causes of end-stage renal disease. The effect of obesity on kidney function decline in stable post-myocardial infarction patients is poorly documented. This relation was investigated in a large cohort of older post-myocardial infarction patients. Design Data were analysed from 2410 post-myocardial infarction patients in the Alpha Omega Trial, aged 60-80 years receiving optimal pharmacotherapy treatment (79% men, 18% diabetes). Methods Cystatin C based estimated glomerular filtration rate (eGFRcysC) was calculated at baseline and after 41 months, using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. Obesity was defined as body mass index ≥ 30 kg/m2 and high waist circumference as ≥102 and ≥88 cm for men and women. The relation between body mass index, waist circumference and annual eGFRcysC decline was evaluated by linear regression. Results At baseline, mean (standard deviation) eGFRcysC was 81.5 (19.6) ml/min/1.73 m2, 23% of all patients were obese. After multivariable adjustment, the annual mean (95% confidence interval) eGFRcysC decline in men and women was -1.45 (-1.59 to -1.31) and -0.92 (-1.20 to -0.63) ml/min/1.73 m2, respectively (p = 0.001). Obese versus non-obese patients and patients with high versus normal waist circumference experienced greater annual eGFRcysC decline. Men and women showed an additional annual eGFRcysC decline of -0.35 (-0.56 to -0.14) and -0.21 (-0.55 to 0.14) ml/min/1.73 m2 per 5 kg/m2 body mass index increment (p for interaction 0.3). Conclusions High compared to normal body mass index or waist circumference were associated with more rapid kidney function decline in older stable post-myocardial infarction patients receiving optimal drug therapy.

Authors+Show Affiliations

1 Department of Nephrology, Leiden University Medical Center, The Netherlands. 2 Department of Clinical Epidemiology, Leiden University Medical Center, The Netherlands.3 Division of Human Nutrition, Wageningen University, The Netherlands.4 Department of Psychiatry, Leiden University Medical Center, The Netherlands.5 Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, The Netherlands.2 Department of Clinical Epidemiology, Leiden University Medical Center, The Netherlands.1 Department of Nephrology, Leiden University Medical Center, The Netherlands.3 Division of Human Nutrition, Wageningen University, The Netherlands. 6 Department of Epidemiology, University Medical Center Groningen, The Netherlands.1 Department of Nephrology, Leiden University Medical Center, The Netherlands. 2 Department of Clinical Epidemiology, Leiden University Medical Center, The Netherlands. 7 Department of Nephrology, Jeroen Bosch Hospital, The Netherlands.

Pub Type(s)

Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

29095051

Citation

Esmeijer, Kevin, et al. "Body-fat Indicators and Kidney Function Decline in Older Post-myocardial Infarction Patients: the Alpha Omega Cohort Study." European Journal of Preventive Cardiology, vol. 25, no. 1, 2018, pp. 90-99.
Esmeijer K, Geleijnse JM, Giltay EJ, et al. Body-fat indicators and kidney function decline in older post-myocardial infarction patients: The Alpha Omega Cohort Study. Eur J Prev Cardiol. 2018;25(1):90-99.
Esmeijer, K., Geleijnse, J. M., Giltay, E. J., Stijnen, T., Dekker, F. W., de Fijter, J. W., ... Hoogeveen, E. K. (2018). Body-fat indicators and kidney function decline in older post-myocardial infarction patients: The Alpha Omega Cohort Study. European Journal of Preventive Cardiology, 25(1), pp. 90-99. doi:10.1177/2047487317739986.
Esmeijer K, et al. Body-fat Indicators and Kidney Function Decline in Older Post-myocardial Infarction Patients: the Alpha Omega Cohort Study. Eur J Prev Cardiol. 2018;25(1):90-99. PubMed PMID: 29095051.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Body-fat indicators and kidney function decline in older post-myocardial infarction patients: The Alpha Omega Cohort Study. AU - Esmeijer,Kevin, AU - Geleijnse,Johanna M, AU - Giltay,Erik J, AU - Stijnen,Theo, AU - Dekker,Friedo W, AU - de Fijter,Johan W, AU - Kromhout,Daan, AU - Hoogeveen,Ellen K, Y1 - 2017/11/02/ PY - 2017/11/3/pubmed PY - 2018/8/7/medline PY - 2017/11/3/entrez KW - Obesity KW - cardiovascular disease KW - kidney function KW - risk factors SP - 90 EP - 99 JF - European journal of preventive cardiology JO - Eur J Prev Cardiol VL - 25 IS - 1 N2 - Background Obesity increases risk of hypertension and diabetes, the leading causes of end-stage renal disease. The effect of obesity on kidney function decline in stable post-myocardial infarction patients is poorly documented. This relation was investigated in a large cohort of older post-myocardial infarction patients. Design Data were analysed from 2410 post-myocardial infarction patients in the Alpha Omega Trial, aged 60-80 years receiving optimal pharmacotherapy treatment (79% men, 18% diabetes). Methods Cystatin C based estimated glomerular filtration rate (eGFRcysC) was calculated at baseline and after 41 months, using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. Obesity was defined as body mass index ≥ 30 kg/m2 and high waist circumference as ≥102 and ≥88 cm for men and women. The relation between body mass index, waist circumference and annual eGFRcysC decline was evaluated by linear regression. Results At baseline, mean (standard deviation) eGFRcysC was 81.5 (19.6) ml/min/1.73 m2, 23% of all patients were obese. After multivariable adjustment, the annual mean (95% confidence interval) eGFRcysC decline in men and women was -1.45 (-1.59 to -1.31) and -0.92 (-1.20 to -0.63) ml/min/1.73 m2, respectively (p = 0.001). Obese versus non-obese patients and patients with high versus normal waist circumference experienced greater annual eGFRcysC decline. Men and women showed an additional annual eGFRcysC decline of -0.35 (-0.56 to -0.14) and -0.21 (-0.55 to 0.14) ml/min/1.73 m2 per 5 kg/m2 body mass index increment (p for interaction 0.3). Conclusions High compared to normal body mass index or waist circumference were associated with more rapid kidney function decline in older stable post-myocardial infarction patients receiving optimal drug therapy. SN - 2047-4881 UR - https://www.unboundmedicine.com/medline/citation/29095051/Body_fat_indicators_and_kidney_function_decline_in_older_post_myocardial_infarction_patients:_The_Alpha_Omega_Cohort_Study_ L2 - http://journals.sagepub.com/doi/full/10.1177/2047487317739986?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -