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Sensitivity and predictive value of serum ferritin and free erythrocyte protoporphyrin for iron deficiency.
J Lab Clin Med. 1989 Jan; 113(1):73-8.JL

Abstract

The sensitivity and predictive value of serum ferritin (SF) and free erythrocyte protoporphyrin (FEP) for iron deficiency (ID) was evaluated by studying 272 subjects with uncomplicated ID (174 with anemia and 98 without) in whom diagnosis was confirmed by the response to iron supplementation. Overall, the sensitivity, at 95% specificity, was 82% (79% in women, 94% in men) for SF and 61% (60% in women, 65% in men) for FEP. The sensitivity varied as a function of hemoglobin values, dropping from over 90% for both tests in the case of severe anemia, to approximately 70% for SF and less than 50% for FEP in the absence of anemia. The predictive value decreases more sharply for FEP than for SF with increasing hemoglobin levels. It is concluded that SF is preferable to FEP for the detection of ID, particularly in the absence of anemia. However, owing to the unsatisfactory predictive value at low prevalence, SF should be used as a screening test for ID without anemia only when the prevalence is at least 20%.

Authors+Show Affiliations

Centro Trasfusionale e di Immunologia dei Trapianti, Ospedale Maggiore Policlinico, Milano, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2909654

Citation

Zanella, A, et al. "Sensitivity and Predictive Value of Serum Ferritin and Free Erythrocyte Protoporphyrin for Iron Deficiency." The Journal of Laboratory and Clinical Medicine, vol. 113, no. 1, 1989, pp. 73-8.
Zanella A, Gridelli L, Berzuini A, et al. Sensitivity and predictive value of serum ferritin and free erythrocyte protoporphyrin for iron deficiency. J Lab Clin Med. 1989;113(1):73-8.
Zanella, A., Gridelli, L., Berzuini, A., Colotti, M. T., Mozzi, F., Milani, S., & Sirchia, G. (1989). Sensitivity and predictive value of serum ferritin and free erythrocyte protoporphyrin for iron deficiency. The Journal of Laboratory and Clinical Medicine, 113(1), 73-8.
Zanella A, et al. Sensitivity and Predictive Value of Serum Ferritin and Free Erythrocyte Protoporphyrin for Iron Deficiency. J Lab Clin Med. 1989;113(1):73-8. PubMed PMID: 2909654.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sensitivity and predictive value of serum ferritin and free erythrocyte protoporphyrin for iron deficiency. AU - Zanella,A, AU - Gridelli,L, AU - Berzuini,A, AU - Colotti,M T, AU - Mozzi,F, AU - Milani,S, AU - Sirchia,G, PY - 1989/1/1/pubmed PY - 1989/1/1/medline PY - 1989/1/1/entrez SP - 73 EP - 8 JF - The Journal of laboratory and clinical medicine JO - J Lab Clin Med VL - 113 IS - 1 N2 - The sensitivity and predictive value of serum ferritin (SF) and free erythrocyte protoporphyrin (FEP) for iron deficiency (ID) was evaluated by studying 272 subjects with uncomplicated ID (174 with anemia and 98 without) in whom diagnosis was confirmed by the response to iron supplementation. Overall, the sensitivity, at 95% specificity, was 82% (79% in women, 94% in men) for SF and 61% (60% in women, 65% in men) for FEP. The sensitivity varied as a function of hemoglobin values, dropping from over 90% for both tests in the case of severe anemia, to approximately 70% for SF and less than 50% for FEP in the absence of anemia. The predictive value decreases more sharply for FEP than for SF with increasing hemoglobin levels. It is concluded that SF is preferable to FEP for the detection of ID, particularly in the absence of anemia. However, owing to the unsatisfactory predictive value at low prevalence, SF should be used as a screening test for ID without anemia only when the prevalence is at least 20%. SN - 0022-2143 UR - https://www.unboundmedicine.com/medline/citation/2909654/Sensitivity_and_predictive_value_of_serum_ferritin_and_free_erythrocyte_protoporphyrin_for_iron_deficiency_ DB - PRIME DP - Unbound Medicine ER -