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Effects of a single preappointment dose of gabapentin on signs of stress in cats during transportation and veterinary examination.
J Am Vet Med Assoc 2017; 251(10):1175-1181JA

Abstract

OBJECTIVE

To determine the effects of oral gabapentin administration prior to veterinary examination on signs of stress in cats. DESIGN Randomized, blinded, crossover clinical trial. ANIMALS 20 healthy pet cats with a history of fractious behavior or signs of stress during veterinary examination. PROCEDURES Cats were scheduled for 2 veterinary visits 1 week apart and randomly assigned to receive a capsule containing 100 mg of gabapentin (13.0 to 29.4 mg/kg [5.9 to 13.4 mg/lb]) or placebo (lactose powder) prior to the first visit and the opposite treatment prior to the second visit. Owners were instructed to administer the assigned capsule orally 90 minutes prior to placing the cat into a carrier and transporting it to the veterinary hospital. Standardized physical examinations and blood pressure readings were performed. Owners assigned a cat stress score during transportation and examination, and the veterinarian assigned a compliance score at the visit. Scores were compared between treatments, controlling for various factors.

RESULTS

Owner-assessed cat stress scores during transportation and veterinary examination and veterinarian-assessed compliance scores were significantly lower when cats received gabapentin than when they received the placebo. Sedation was a common effect of gabapentin administration, and ataxia, hypersalivation, and vomiting were also reported. All effects resolved within 8 hours after gabapentin administration.

CONCLUSIONS

AND CLINICAL RELEVANCE Owners' perception of stress in their cats is a primary reason for failing to seek veterinary care. Results of this study suggested that gabapentin is a safe and effective treatment for cats to help reduce stress and aggression and increase compliance for transportation and veterinary examination.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

29099247

Citation

van Haaften, Karen A., et al. "Effects of a Single Preappointment Dose of Gabapentin On Signs of Stress in Cats During Transportation and Veterinary Examination." Journal of the American Veterinary Medical Association, vol. 251, no. 10, 2017, pp. 1175-1181.
van Haaften KA, Forsythe LRE, Stelow EA, et al. Effects of a single preappointment dose of gabapentin on signs of stress in cats during transportation and veterinary examination. J Am Vet Med Assoc. 2017;251(10):1175-1181.
van Haaften, K. A., Forsythe, L. R. E., Stelow, E. A., & Bain, M. J. (2017). Effects of a single preappointment dose of gabapentin on signs of stress in cats during transportation and veterinary examination. Journal of the American Veterinary Medical Association, 251(10), pp. 1175-1181. doi:10.2460/javma.251.10.1175.
van Haaften KA, et al. Effects of a Single Preappointment Dose of Gabapentin On Signs of Stress in Cats During Transportation and Veterinary Examination. J Am Vet Med Assoc. 2017 Nov 15;251(10):1175-1181. PubMed PMID: 29099247.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of a single preappointment dose of gabapentin on signs of stress in cats during transportation and veterinary examination. AU - van Haaften,Karen A, AU - Forsythe,Lauren R Eichstadt, AU - Stelow,Elizabeth A, AU - Bain,Melissa J, PY - 2017/11/4/entrez PY - 2017/11/4/pubmed PY - 2018/1/10/medline SP - 1175 EP - 1181 JF - Journal of the American Veterinary Medical Association JO - J. Am. Vet. Med. Assoc. VL - 251 IS - 10 N2 - OBJECTIVE To determine the effects of oral gabapentin administration prior to veterinary examination on signs of stress in cats. DESIGN Randomized, blinded, crossover clinical trial. ANIMALS 20 healthy pet cats with a history of fractious behavior or signs of stress during veterinary examination. PROCEDURES Cats were scheduled for 2 veterinary visits 1 week apart and randomly assigned to receive a capsule containing 100 mg of gabapentin (13.0 to 29.4 mg/kg [5.9 to 13.4 mg/lb]) or placebo (lactose powder) prior to the first visit and the opposite treatment prior to the second visit. Owners were instructed to administer the assigned capsule orally 90 minutes prior to placing the cat into a carrier and transporting it to the veterinary hospital. Standardized physical examinations and blood pressure readings were performed. Owners assigned a cat stress score during transportation and examination, and the veterinarian assigned a compliance score at the visit. Scores were compared between treatments, controlling for various factors. RESULTS Owner-assessed cat stress scores during transportation and veterinary examination and veterinarian-assessed compliance scores were significantly lower when cats received gabapentin than when they received the placebo. Sedation was a common effect of gabapentin administration, and ataxia, hypersalivation, and vomiting were also reported. All effects resolved within 8 hours after gabapentin administration. CONCLUSIONS AND CLINICAL RELEVANCE Owners' perception of stress in their cats is a primary reason for failing to seek veterinary care. Results of this study suggested that gabapentin is a safe and effective treatment for cats to help reduce stress and aggression and increase compliance for transportation and veterinary examination. SN - 1943-569X UR - https://www.unboundmedicine.com/medline/citation/29099247/Effects_of_a_single_preappointment_dose_of_gabapentin_on_signs_of_stress_in_cats_during_transportation_and_veterinary_examination_ L2 - http://avmajournals.avma.org/doi/full/10.2460/javma.251.10.1175?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -