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The Society for Obstetric Anesthesia and Perinatology Consensus Statement on the Anesthetic Management of Pregnant and Postpartum Women Receiving Thromboprophylaxis or Higher Dose Anticoagulants.
Anesth Analg. 2018 03; 126(3):928-944.A&A

Abstract

Venous thromboembolism is recognized as a leading cause of maternal death in the United States. Thromboprophylaxis has been highlighted as a key preventive measure to reduce venous thromboembolism-related maternal deaths. However, the expanded use of thromboprophylaxis in obstetrics will have a major impact on the use and timing of neuraxial analgesia and anesthesia for women undergoing vaginal or cesarean delivery and other obstetric surgeries. Experts from the Society of Obstetric Anesthesia and Perinatology, the American Society of Regional Anesthesia, and hematology have collaborated to develop this comprehensive, pregnancy-specific consensus statement on neuraxial procedures in obstetric patients receiving thromboprophylaxis or higher dose anticoagulants. To date, none of the existing anesthesia societies' recommendations have weighed the potential risks of neuraxial procedures in the presence of thromboprophylaxis, with the competing risks of general anesthesia with a potentially difficult airway, or maternal or fetal harm from avoidance or delayed neuraxial anesthesia. Furthermore, existing guidelines have not integrated the pharmacokinetics and pharmacodynamics of anticoagulants in the obstetric population. The goal of this consensus statement is to provide a practical guide of how to appropriately identify, prepare, and manage pregnant women receiving thromboprophylaxis or higher dose anticoagulants during the ante-, intra-, and postpartum periods. The tactics to facilitate multidisciplinary communication, evidence-based pharmacokinetic and spinal epidural hematoma data, and Decision Aids should help inform risk-benefit discussions with patients and facilitate shared decision making.

Authors+Show Affiliations

From the Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts.Department of Anesthesia, Stanford University School of Medicine, Stanford, California.Department of Anesthesia, Stanford University School of Medicine, Stanford, California.Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota.Department of Medicine, Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada.Departments of Obstetrics and Gynecology.Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota.From the Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts.Anesthesiology, Columbia University College of Physicians and Surgeons, New York, New York.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Consensus Development Conference
Journal Article

Language

eng

PubMed ID

29099429

Citation

Leffert, Lisa, et al. "The Society for Obstetric Anesthesia and Perinatology Consensus Statement On the Anesthetic Management of Pregnant and Postpartum Women Receiving Thromboprophylaxis or Higher Dose Anticoagulants." Anesthesia and Analgesia, vol. 126, no. 3, 2018, pp. 928-944.
Leffert L, Butwick A, Carvalho B, et al. The Society for Obstetric Anesthesia and Perinatology Consensus Statement on the Anesthetic Management of Pregnant and Postpartum Women Receiving Thromboprophylaxis or Higher Dose Anticoagulants. Anesth Analg. 2018;126(3):928-944.
Leffert, L., Butwick, A., Carvalho, B., Arendt, K., Bates, S. M., Friedman, A., Horlocker, T., Houle, T., Landau, R., Dubois, H., Fernando, R., Houle, T., Kopp, S., Montgomery, D., Pellegrini, J., Smiley, R., & Toledo, P. (2018). The Society for Obstetric Anesthesia and Perinatology Consensus Statement on the Anesthetic Management of Pregnant and Postpartum Women Receiving Thromboprophylaxis or Higher Dose Anticoagulants. Anesthesia and Analgesia, 126(3), 928-944. https://doi.org/10.1213/ANE.0000000000002530
Leffert L, et al. The Society for Obstetric Anesthesia and Perinatology Consensus Statement On the Anesthetic Management of Pregnant and Postpartum Women Receiving Thromboprophylaxis or Higher Dose Anticoagulants. Anesth Analg. 2018;126(3):928-944. PubMed PMID: 29099429.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Society for Obstetric Anesthesia and Perinatology Consensus Statement on the Anesthetic Management of Pregnant and Postpartum Women Receiving Thromboprophylaxis or Higher Dose Anticoagulants. AU - Leffert,Lisa, AU - Butwick,Alexander, AU - Carvalho,Brendan, AU - Arendt,Katherine, AU - Bates,Shannon M, AU - Friedman,Alex, AU - Horlocker,Terese, AU - Houle,Timothy, AU - Landau,Ruth, AU - Dubois,Heloise, AU - Fernando,Roshan, AU - Houle,Tim, AU - Kopp,Sandra, AU - Montgomery,Douglas, AU - Pellegrini,Joseph, AU - Smiley,Richard, AU - Toledo,Paloma, AU - ,, PY - 2017/11/4/pubmed PY - 2019/1/1/medline PY - 2017/11/4/entrez SP - 928 EP - 944 JF - Anesthesia and analgesia JO - Anesth Analg VL - 126 IS - 3 N2 - Venous thromboembolism is recognized as a leading cause of maternal death in the United States. Thromboprophylaxis has been highlighted as a key preventive measure to reduce venous thromboembolism-related maternal deaths. However, the expanded use of thromboprophylaxis in obstetrics will have a major impact on the use and timing of neuraxial analgesia and anesthesia for women undergoing vaginal or cesarean delivery and other obstetric surgeries. Experts from the Society of Obstetric Anesthesia and Perinatology, the American Society of Regional Anesthesia, and hematology have collaborated to develop this comprehensive, pregnancy-specific consensus statement on neuraxial procedures in obstetric patients receiving thromboprophylaxis or higher dose anticoagulants. To date, none of the existing anesthesia societies' recommendations have weighed the potential risks of neuraxial procedures in the presence of thromboprophylaxis, with the competing risks of general anesthesia with a potentially difficult airway, or maternal or fetal harm from avoidance or delayed neuraxial anesthesia. Furthermore, existing guidelines have not integrated the pharmacokinetics and pharmacodynamics of anticoagulants in the obstetric population. The goal of this consensus statement is to provide a practical guide of how to appropriately identify, prepare, and manage pregnant women receiving thromboprophylaxis or higher dose anticoagulants during the ante-, intra-, and postpartum periods. The tactics to facilitate multidisciplinary communication, evidence-based pharmacokinetic and spinal epidural hematoma data, and Decision Aids should help inform risk-benefit discussions with patients and facilitate shared decision making. SN - 1526-7598 UR - https://www.unboundmedicine.com/medline/citation/29099429/The_Society_for_Obstetric_Anesthesia_and_Perinatology_Consensus_Statement_on_the_Anesthetic_Management_of_Pregnant_and_Postpartum_Women_Receiving_Thromboprophylaxis_or_Higher_Dose_Anticoagulants_ L2 - https://doi.org/10.1213/ANE.0000000000002530 DB - PRIME DP - Unbound Medicine ER -