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Hints on transcriptional control of essential players in heterotopic ossification of Fibrodysplasia Ossificans Progressiva.
Bone. 2018 04; 109:187-191.BONE

Abstract

Signaling of the Bone Morphogenetic Protein (BMP) pathway is influenced by the level of expression of its components, in particular receptors, intracellular molecules and target genes which largely depends on gene transcription. One peculiar aspect of Fibrodysplasia Ossificans Progressiva (FOP) relates to the cell types in which the genetic mutation exerts its effects, then not only those involved in the heterotopic ossification processes but also others that participate in the inflammatory phases preceding and triggering heterotopic ossification. Such effects are in part detectable as variation in gene expression, which is also variably manifesting in term of time of appearance in different phases of the inflammatory or ossification processes.

Authors+Show Affiliations

DINOGMI Department, University of Genova, Genova, Italy; Medical Genetics Unit, Istituto Giannina Gaslini, Genova, Italy. Electronic address: rravazzo@unige.it.DINOGMI Department, University of Genova, Genova, Italy.DINOGMI Department, University of Genova, Genova, Italy; Medical Genetics Unit, Istituto Giannina Gaslini, Genova, Italy.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

29100956

Citation

Ravazzolo, Roberto, et al. "Hints On Transcriptional Control of Essential Players in Heterotopic Ossification of Fibrodysplasia Ossificans Progressiva." Bone, vol. 109, 2018, pp. 187-191.
Ravazzolo R, Cappato S, Bocciardi R. Hints on transcriptional control of essential players in heterotopic ossification of Fibrodysplasia Ossificans Progressiva. Bone. 2018;109:187-191.
Ravazzolo, R., Cappato, S., & Bocciardi, R. (2018). Hints on transcriptional control of essential players in heterotopic ossification of Fibrodysplasia Ossificans Progressiva. Bone, 109, 187-191. https://doi.org/10.1016/j.bone.2017.10.028
Ravazzolo R, Cappato S, Bocciardi R. Hints On Transcriptional Control of Essential Players in Heterotopic Ossification of Fibrodysplasia Ossificans Progressiva. Bone. 2018;109:187-191. PubMed PMID: 29100956.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hints on transcriptional control of essential players in heterotopic ossification of Fibrodysplasia Ossificans Progressiva. AU - Ravazzolo,Roberto, AU - Cappato,Serena, AU - Bocciardi,Renata, Y1 - 2017/10/31/ PY - 2017/07/03/received PY - 2017/10/30/revised PY - 2017/10/30/accepted PY - 2017/11/5/pubmed PY - 2018/11/20/medline PY - 2017/11/5/entrez KW - ACVR1/Alk2 KW - Activin KW - BMP KW - Fibrodysplasia Ossificans Progressiva (FOP) KW - Follistatin KW - Heterotopic ossification KW - Smad KW - Transcriptional regulation SP - 187 EP - 191 JF - Bone JO - Bone VL - 109 N2 - Signaling of the Bone Morphogenetic Protein (BMP) pathway is influenced by the level of expression of its components, in particular receptors, intracellular molecules and target genes which largely depends on gene transcription. One peculiar aspect of Fibrodysplasia Ossificans Progressiva (FOP) relates to the cell types in which the genetic mutation exerts its effects, then not only those involved in the heterotopic ossification processes but also others that participate in the inflammatory phases preceding and triggering heterotopic ossification. Such effects are in part detectable as variation in gene expression, which is also variably manifesting in term of time of appearance in different phases of the inflammatory or ossification processes. SN - 1873-2763 UR - https://www.unboundmedicine.com/medline/citation/29100956/Hints_on_transcriptional_control_of_essential_players_in_heterotopic_ossification_of_Fibrodysplasia_Ossificans_Progressiva_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S8756-3282(17)30394-0 DB - PRIME DP - Unbound Medicine ER -