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Clinical characteristics of myelin oligodendrocyte glycoprotein seropositive optic neuritis: a cohort study in Shanghai, China.
J Neurol. 2018 Jan; 265(1):33-40.JN

Abstract

Qualitative and quantitative visual outcomes of Asian optic neuritis (ON) patients with seropositive myelin oligodendrocyte glycoprotein (MOG) antibodies remain unknown. We retrospectively evaluated a cohort of new-onset ON patients in Shanghai, China between January 2015 and December 2016. Serum MOG and aquaporin-4 (AQP4) antibodies were detected using cell-based assays, and patients were followed-up for at least 6 months. The clinical characteristics and optical coherence tomography (OCT) results were evaluated in the MOG-seropositive optic neuritis (MOG-ON), AQP4-seropositive (AQP4-ON), and double seronegative (Seronegative-ON) patients. Best-corrected visual acuity (BCVA) and peripapillary retinal nerve fiber layer (RNFL) thickness after 6 months of follow-up were compared. Among MOG-ON (n = 49, 64 eyes), AQP4-ON (n = 76, 102 eyes), and Seronegative-ON patients (n = 100, 116 eyes), the percentages of BCVAs better than 0.8 (20/25) at the 6-month visit were 67.19, 19.60, and 72.41%, respectively, which showed no statistical difference between MOG-ON and Seronegative-ON patients (p = 0.198), but were better than the AQP4-ON patients (P = 0.001). The average peripapillary RNFLs measured 6 months after the attack were 58.03 ± 8.73, 64.34 ± 12.88, and 78.12 ± 13.34 μm for the MOG-ON, AQP4-ON, and Seronegative-ON patients, respectively. There was no statistical difference between MOG-ON and AQP4-ON patients (P = 0.089), but both were thinner than Seronegative-ON patients (P = 0.001). The visual acuity in MOG-ON patients was as good as Seronegative-ON patients, whereas the RNFL of the optic nerve head showed a significant thinning as in the AQP4-ON patients.

Authors+Show Affiliations

Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.Department of Ophthalmology, Eye Ear Nose and Throat Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China.Department of Ophthalmology, Eye Ear Nose and Throat Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China.Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.Department of Ophthalmology, Eye Ear Nose and Throat Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China. State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Fudan University, Shanghai, China.Department of Radiology, Eye Ear Nose and Throat Hospital of Fudan University, Shanghai, China.Department of Radiology, Eye Ear Nose and Throat Hospital of Fudan University, Shanghai, China.Department of Ophthalmology, Eye Ear Nose and Throat Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China. wangmin83@yahoo.com. State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Fudan University, Shanghai, China. wangmin83@yahoo.com.Department of Ophthalmology, Eye Ear Nose and Throat Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China. valentian99@hotmail.com. State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Fudan University, Shanghai, China. valentian99@hotmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29101456

Citation

Zhao, Guixian, et al. "Clinical Characteristics of Myelin Oligodendrocyte Glycoprotein Seropositive Optic Neuritis: a Cohort Study in Shanghai, China." Journal of Neurology, vol. 265, no. 1, 2018, pp. 33-40.
Zhao G, Chen Q, Huang Y, et al. Clinical characteristics of myelin oligodendrocyte glycoprotein seropositive optic neuritis: a cohort study in Shanghai, China. J Neurol. 2018;265(1):33-40.
Zhao, G., Chen, Q., Huang, Y., Li, Z., Sun, X., Lu, P., Yan, S., Wang, M., & Tian, G. (2018). Clinical characteristics of myelin oligodendrocyte glycoprotein seropositive optic neuritis: a cohort study in Shanghai, China. Journal of Neurology, 265(1), 33-40. https://doi.org/10.1007/s00415-017-8651-4
Zhao G, et al. Clinical Characteristics of Myelin Oligodendrocyte Glycoprotein Seropositive Optic Neuritis: a Cohort Study in Shanghai, China. J Neurol. 2018;265(1):33-40. PubMed PMID: 29101456.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical characteristics of myelin oligodendrocyte glycoprotein seropositive optic neuritis: a cohort study in Shanghai, China. AU - Zhao,Guixian, AU - Chen,Qian, AU - Huang,Yongheng, AU - Li,Zhenxin, AU - Sun,Xinghuai, AU - Lu,Ping, AU - Yan,S, AU - Wang,Min, AU - Tian,Guohong, Y1 - 2017/11/03/ PY - 2017/07/28/received PY - 2017/10/18/accepted PY - 2017/10/01/revised PY - 2017/11/5/pubmed PY - 2018/7/28/medline PY - 2017/11/5/entrez KW - Aquaporin-4 (AQP4) KW - Myelin oligodendrocyte glycoprotein (MOG) KW - Neuromyelitis optica (NMO) KW - Optic neuritis SP - 33 EP - 40 JF - Journal of neurology JO - J. Neurol. VL - 265 IS - 1 N2 - Qualitative and quantitative visual outcomes of Asian optic neuritis (ON) patients with seropositive myelin oligodendrocyte glycoprotein (MOG) antibodies remain unknown. We retrospectively evaluated a cohort of new-onset ON patients in Shanghai, China between January 2015 and December 2016. Serum MOG and aquaporin-4 (AQP4) antibodies were detected using cell-based assays, and patients were followed-up for at least 6 months. The clinical characteristics and optical coherence tomography (OCT) results were evaluated in the MOG-seropositive optic neuritis (MOG-ON), AQP4-seropositive (AQP4-ON), and double seronegative (Seronegative-ON) patients. Best-corrected visual acuity (BCVA) and peripapillary retinal nerve fiber layer (RNFL) thickness after 6 months of follow-up were compared. Among MOG-ON (n = 49, 64 eyes), AQP4-ON (n = 76, 102 eyes), and Seronegative-ON patients (n = 100, 116 eyes), the percentages of BCVAs better than 0.8 (20/25) at the 6-month visit were 67.19, 19.60, and 72.41%, respectively, which showed no statistical difference between MOG-ON and Seronegative-ON patients (p = 0.198), but were better than the AQP4-ON patients (P = 0.001). The average peripapillary RNFLs measured 6 months after the attack were 58.03 ± 8.73, 64.34 ± 12.88, and 78.12 ± 13.34 μm for the MOG-ON, AQP4-ON, and Seronegative-ON patients, respectively. There was no statistical difference between MOG-ON and AQP4-ON patients (P = 0.089), but both were thinner than Seronegative-ON patients (P = 0.001). The visual acuity in MOG-ON patients was as good as Seronegative-ON patients, whereas the RNFL of the optic nerve head showed a significant thinning as in the AQP4-ON patients. SN - 1432-1459 UR - https://www.unboundmedicine.com/medline/citation/29101456/Clinical_characteristics_of_myelin_oligodendrocyte_glycoprotein_seropositive_optic_neuritis:_a_cohort_study_in_Shanghai_China_ L2 - https://dx.doi.org/10.1007/s00415-017-8651-4 DB - PRIME DP - Unbound Medicine ER -