Tags

Type your tag names separated by a space and hit enter

Brown Adipose Tissue: an Update on Recent Findings.
Curr Obes Rep. 2017 Dec; 6(4):389-396.CO

Abstract

PURPOSE OF REVIEW

New treatment approaches to weight loss and weight loss maintenance in humans are critical. Given its potential role in stimulating energy expenditure, brown adipose tissue (BAT) activation has become a trending topic as an anti-obesity treatment.

RECENT FINDINGS

Most studies on BAT stimulation have been conducted in rodents and used cold stimulation. To date, few human trials exist that tested the effect of cold exposure on BAT. Those studies show that BAT contributes a small amount to overall energy metabolism which is unlikely to cause weight loss. Nonetheless, improvements in glucose metabolism have been demonstrated in humans. While new pharmacological approaches demonstrate some contribution of BAT to overall energy expenditure, the potential cardiovascular risk (increased heart rate and blood pressure to sustain the extra energy expenditure) may preclude their use. There is no convincing evidence yet to indicate that BAT may be a viable pharmaceutical target for body weight loss or even weight loss maintenance. More research is needed to confirm the relevance of BAT and beige tissue to whole-body energy metabolism in humans.

Authors+Show Affiliations

Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA. eric.ravussin@pbrc.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29101739

Citation

Marlatt, Kara L., and Eric Ravussin. "Brown Adipose Tissue: an Update On Recent Findings." Current Obesity Reports, vol. 6, no. 4, 2017, pp. 389-396.
Marlatt KL, Ravussin E. Brown Adipose Tissue: an Update on Recent Findings. Curr Obes Rep. 2017;6(4):389-396.
Marlatt, K. L., & Ravussin, E. (2017). Brown Adipose Tissue: an Update on Recent Findings. Current Obesity Reports, 6(4), 389-396. https://doi.org/10.1007/s13679-017-0283-6
Marlatt KL, Ravussin E. Brown Adipose Tissue: an Update On Recent Findings. Curr Obes Rep. 2017;6(4):389-396. PubMed PMID: 29101739.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Brown Adipose Tissue: an Update on Recent Findings. AU - Marlatt,Kara L, AU - Ravussin,Eric, PY - 2017/11/5/pubmed PY - 2018/7/17/medline PY - 2017/11/5/entrez KW - Beige KW - Brite KW - Brown adipose tissue, BAT KW - Capsaicin KW - Capsinoids KW - Cold acclimation KW - Cold exposure KW - Cold-induced thermogenesis, CIT KW - Diet-induced thermogenesis, DIT KW - Energy balance KW - Thermogenesis KW - Uncoupling protein 1, UCP1 KW - β3-adrenoreceptor agonists SP - 389 EP - 396 JF - Current obesity reports JO - Curr Obes Rep VL - 6 IS - 4 N2 - PURPOSE OF REVIEW: New treatment approaches to weight loss and weight loss maintenance in humans are critical. Given its potential role in stimulating energy expenditure, brown adipose tissue (BAT) activation has become a trending topic as an anti-obesity treatment. RECENT FINDINGS: Most studies on BAT stimulation have been conducted in rodents and used cold stimulation. To date, few human trials exist that tested the effect of cold exposure on BAT. Those studies show that BAT contributes a small amount to overall energy metabolism which is unlikely to cause weight loss. Nonetheless, improvements in glucose metabolism have been demonstrated in humans. While new pharmacological approaches demonstrate some contribution of BAT to overall energy expenditure, the potential cardiovascular risk (increased heart rate and blood pressure to sustain the extra energy expenditure) may preclude their use. There is no convincing evidence yet to indicate that BAT may be a viable pharmaceutical target for body weight loss or even weight loss maintenance. More research is needed to confirm the relevance of BAT and beige tissue to whole-body energy metabolism in humans. SN - 2162-4968 UR - https://www.unboundmedicine.com/medline/citation/29101739/Brown_Adipose_Tissue:_an_Update_on_Recent_Findings_ L2 - https://dx.doi.org/10.1007/s13679-017-0283-6 DB - PRIME DP - Unbound Medicine ER -