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Can highly cited herbs in ancient Traditional Chinese medicine formulas and modern publications predict therapeutic targets for diabetes mellitus?
J Ethnopharmacol. 2018 Mar 01; 213:101-110.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

The prevalence of diabetes among all age groups worldwide was estimated to be more than 382 million in 2013. Traditional Chinese medicine (TCM) has been practiced for thousands of years, and substantial valuable experience and prescriptions have been accumulated in the TCM system for the treatment of diabetes. In recent decades, a large amount of experimental and clinical data has been published on the use of herbal medicines related to these ancient TCM prescriptions.

AIM OF THE STUDY

This study aimed to discover a method for the investigation of potential antidiabetic herbs from the large amount of data in ancient TCM formulas and modern publications and to verify this method through an in vitro bioactivity study.

MATERIALS AND METHODS

In our review, the most frequently cited TCM herbs were selected as potential antidiabetic herb candidates on the basis of TCM philosophical theory (ancient TCM formulas) and Western medicine philosophical theory (modern publications). The ethanol and aqueous extracts of the selected herbs were screened for their α-glucosidase inhibitory, glucose-stimulated insulin secretion (GSIS), and intestinal glucose transport inhibitory effects.

RESULTS

Twelve herbs [Terminalia chebula Retz., fructus immaturus, dried; Poria cocos (Schw) Wolf., sclerotium, dried; Zea mays L., stigma, dried; Pueraria lobata (Willd.) Ohwi, radix, dried; Cucurbita moschata (Duch. ex Lam.) Duch. ex Poiret, fructus, dried; Lycium barbarum L., fructus, dried; Glycine max (L.) Merr., semen, fermented; Glycyrrhiza uralensis Fisch., radix and rhizoma, dried; Dioscorea opposita Thunb., rhizoma, dried; Morus alba L., folium, dried, Morus alba L., fructus, dried; and Polygonatum odoratum (Mill.) Druce, rhizoma, dried] were finally selected as candidates with potential glucose-lowering effects after a review was performed of herbs that are frequently cited in ancient TCM formulas and modern publications. The bioactive study results demonstrated that both the ethanol extracts and crude polysaccharides of M. alba L., fructus, dried, and M. alba L., folium, dried, and the crude polysaccharides of T. chebula Retz., fructus immaturus, dried, exhibited α-glucosidase inhibitory effects. Moreover, the crude polysaccharides of P. cocos (Schw) Wolf., sclerotium, dried; Z. mays L., stigma, dried; and T. chebula Retz., fructus immaturus, dried, exhibited favorable GSIS effects, and the ethanol extracts of P. odoratum (Mill.) Druce, rhizoma, dried; T. chebula Retz., fructus immaturus, dried; and G. uralensis Fisch., radix and rhizoma, dried, significantly decreased glucose transport across the cell monolayer.

CONCLUSIONS

Our review and the preliminary bioactive study revealed that 10 of the 12 recommended edible TCM herbs had favorable antidiabetic effects, demonstrating that TCM herbs with a high prescription and publication frequency may provide insights into the potential therapeutic targets of diabetes mellitus and may aid in the discovery of effective compounds complementary to currently used medicines. Such a literature and medicine review is a useful method of exploring potential antidiabetic herbs by using the wealth of information in ancient TCM formulas and modern publications.

Authors+Show Affiliations

The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, PR China; Central Research Institute, Shanghai Pharmaceuticals Holding Co., Ltd., Building 5, 898 Halei Road, Shanghai 201203, PR China. Electronic address: huijun.wang@outlook.com.The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, PR China. Electronic address: shisongshan1978@126.com.The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, PR China. Electronic address: shunchunwang@126.com.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29102765

Citation

Wang, Huijun, et al. "Can Highly Cited Herbs in Ancient Traditional Chinese Medicine Formulas and Modern Publications Predict Therapeutic Targets for Diabetes Mellitus?" Journal of Ethnopharmacology, vol. 213, 2018, pp. 101-110.
Wang H, Shi S, Wang S. Can highly cited herbs in ancient Traditional Chinese medicine formulas and modern publications predict therapeutic targets for diabetes mellitus? J Ethnopharmacol. 2018;213:101-110.
Wang, H., Shi, S., & Wang, S. (2018). Can highly cited herbs in ancient Traditional Chinese medicine formulas and modern publications predict therapeutic targets for diabetes mellitus? Journal of Ethnopharmacology, 213, 101-110. https://doi.org/10.1016/j.jep.2017.10.032
Wang H, Shi S, Wang S. Can Highly Cited Herbs in Ancient Traditional Chinese Medicine Formulas and Modern Publications Predict Therapeutic Targets for Diabetes Mellitus. J Ethnopharmacol. 2018 Mar 1;213:101-110. PubMed PMID: 29102765.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Can highly cited herbs in ancient Traditional Chinese medicine formulas and modern publications predict therapeutic targets for diabetes mellitus? AU - Wang,Huijun, AU - Shi,Songshan, AU - Wang,Shunchun, Y1 - 2017/11/02/ PY - 2016/03/12/received PY - 2017/08/08/revised PY - 2017/10/31/accepted PY - 2017/11/6/pubmed PY - 2018/8/7/medline PY - 2017/11/6/entrez KW - 1-Deoxynojirimycin (PubChem CID: 29435) KW - Ancient TCM formulas KW - Diabetes mellitus KW - Edible herbs KW - Exendin-4 (PubChem CID: 56927919) KW - Modern publications KW - Phloretin (PubChem CID: 4788) KW - Phloridzin (PubChem CID: 6072) KW - Traditional Chinese medicine SP - 101 EP - 110 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 213 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: The prevalence of diabetes among all age groups worldwide was estimated to be more than 382 million in 2013. Traditional Chinese medicine (TCM) has been practiced for thousands of years, and substantial valuable experience and prescriptions have been accumulated in the TCM system for the treatment of diabetes. In recent decades, a large amount of experimental and clinical data has been published on the use of herbal medicines related to these ancient TCM prescriptions. AIM OF THE STUDY: This study aimed to discover a method for the investigation of potential antidiabetic herbs from the large amount of data in ancient TCM formulas and modern publications and to verify this method through an in vitro bioactivity study. MATERIALS AND METHODS: In our review, the most frequently cited TCM herbs were selected as potential antidiabetic herb candidates on the basis of TCM philosophical theory (ancient TCM formulas) and Western medicine philosophical theory (modern publications). The ethanol and aqueous extracts of the selected herbs were screened for their α-glucosidase inhibitory, glucose-stimulated insulin secretion (GSIS), and intestinal glucose transport inhibitory effects. RESULTS: Twelve herbs [Terminalia chebula Retz., fructus immaturus, dried; Poria cocos (Schw) Wolf., sclerotium, dried; Zea mays L., stigma, dried; Pueraria lobata (Willd.) Ohwi, radix, dried; Cucurbita moschata (Duch. ex Lam.) Duch. ex Poiret, fructus, dried; Lycium barbarum L., fructus, dried; Glycine max (L.) Merr., semen, fermented; Glycyrrhiza uralensis Fisch., radix and rhizoma, dried; Dioscorea opposita Thunb., rhizoma, dried; Morus alba L., folium, dried, Morus alba L., fructus, dried; and Polygonatum odoratum (Mill.) Druce, rhizoma, dried] were finally selected as candidates with potential glucose-lowering effects after a review was performed of herbs that are frequently cited in ancient TCM formulas and modern publications. The bioactive study results demonstrated that both the ethanol extracts and crude polysaccharides of M. alba L., fructus, dried, and M. alba L., folium, dried, and the crude polysaccharides of T. chebula Retz., fructus immaturus, dried, exhibited α-glucosidase inhibitory effects. Moreover, the crude polysaccharides of P. cocos (Schw) Wolf., sclerotium, dried; Z. mays L., stigma, dried; and T. chebula Retz., fructus immaturus, dried, exhibited favorable GSIS effects, and the ethanol extracts of P. odoratum (Mill.) Druce, rhizoma, dried; T. chebula Retz., fructus immaturus, dried; and G. uralensis Fisch., radix and rhizoma, dried, significantly decreased glucose transport across the cell monolayer. CONCLUSIONS: Our review and the preliminary bioactive study revealed that 10 of the 12 recommended edible TCM herbs had favorable antidiabetic effects, demonstrating that TCM herbs with a high prescription and publication frequency may provide insights into the potential therapeutic targets of diabetes mellitus and may aid in the discovery of effective compounds complementary to currently used medicines. Such a literature and medicine review is a useful method of exploring potential antidiabetic herbs by using the wealth of information in ancient TCM formulas and modern publications. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/29102765/Can_highly_cited_herbs_in_ancient_Traditional_Chinese_medicine_formulas_and_modern_publications_predict_therapeutic_targets_for_diabetes_mellitus L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(17)33976-4 DB - PRIME DP - Unbound Medicine ER -