Tags

Type your tag names separated by a space and hit enter

Non-steroidal anti-inflammatory drugs attenuate agonist-evoked activation of transient receptor potential channels.
Biomed Pharmacother. 2018 Jan; 97:745-751.BP

Abstract

Transient receptor potential (TRP) cation channels are the largest group of sensory detector proteins expressed in the nerve terminals of many receptors including nociceptors, and are activated by temperature and chemicals that elicit hot or cold sensations. Antagonists of these channels are likely promising targets for new analgesic drugs at the peripheral and central levels. Because some non-steroidal anti-inflammatory drugs (NSAIDs) are structural analogs of prostaglandins and NSAIDs attenuate heat nociception and mechanical allodynia in models of inflammatory and neuropathic pain, we investigated whether three widely used NSAIDs (diclofenac, ketorolac, and xefocam) affect thermal and mechanical hyperalgesia following the activation of TRPA1 and TRPV1 channels. We measured nociceptive thermal paw withdrawal latencies and mechanical thresholds bilaterally at various time points following intraplantar injection of the TRPA1 agonists, cinnamaldehyde (CA) and allyl isothiocyanate (AITC) or the TRPV1 agonist capsaicin, or vehicle. When pretreated with vehicle, intraplantar injection of CA, AITC and capsaicin each resulted in significant decreases in thermal withdrawal latency and mechanical threshold in the ipsilateral hindpaw that did not return to baseline for more than 2h. To test effects of NSAIDS either diclofenac, ketorolac or xefocam was pre-injected in the same hindpaw 35min prior to CA, AITC or capsaicin. Pretreatment with each of the three NSAIDs produced strong antinociceptive and antihyperalgesic effects lasting approximately 60min. Thus, we show for the first time that local administration of NSAIDs reduces thermal and mechanical hyperalgesia following TRPA1 or TRPV1 activation.

Authors+Show Affiliations

Laboratory of Pain and Analgesia, Beritashvili Center for Experimental Biomedicine, Tbilisi, Georgia. Electronic address: m.tsagareli@biomedicine.org.ge.Laboratory of Pain and Analgesia, Beritashvili Center for Experimental Biomedicine, Tbilisi, Georgia.Laboratory of Pain and Analgesia, Beritashvili Center for Experimental Biomedicine, Tbilisi, Georgia.Laboratory of Pain and Analgesia, Beritashvili Center for Experimental Biomedicine, Tbilisi, Georgia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29102918

Citation

Tsagareli, M G., et al. "Non-steroidal Anti-inflammatory Drugs Attenuate Agonist-evoked Activation of Transient Receptor Potential Channels." Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, vol. 97, 2018, pp. 745-751.
Tsagareli MG, Nozadze I, Tsiklauri N, et al. Non-steroidal anti-inflammatory drugs attenuate agonist-evoked activation of transient receptor potential channels. Biomed Pharmacother. 2018;97:745-751.
Tsagareli, M. G., Nozadze, I., Tsiklauri, N., & Gurtskaia, G. (2018). Non-steroidal anti-inflammatory drugs attenuate agonist-evoked activation of transient receptor potential channels. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 97, 745-751. https://doi.org/10.1016/j.biopha.2017.10.131
Tsagareli MG, et al. Non-steroidal Anti-inflammatory Drugs Attenuate Agonist-evoked Activation of Transient Receptor Potential Channels. Biomed Pharmacother. 2018;97:745-751. PubMed PMID: 29102918.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Non-steroidal anti-inflammatory drugs attenuate agonist-evoked activation of transient receptor potential channels. AU - Tsagareli,M G, AU - Nozadze,I, AU - Tsiklauri,N, AU - Gurtskaia,G, Y1 - 2017/11/06/ PY - 2017/08/02/received PY - 2017/10/02/revised PY - 2017/10/23/accepted PY - 2017/11/6/pubmed PY - 2018/8/2/medline PY - 2017/11/6/entrez KW - Allodynia KW - Cold pain KW - Heat pain KW - Hyperalgesia KW - Nociception KW - Sensory neurons KW - Signal transduction SP - 745 EP - 751 JF - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie JO - Biomed Pharmacother VL - 97 N2 - Transient receptor potential (TRP) cation channels are the largest group of sensory detector proteins expressed in the nerve terminals of many receptors including nociceptors, and are activated by temperature and chemicals that elicit hot or cold sensations. Antagonists of these channels are likely promising targets for new analgesic drugs at the peripheral and central levels. Because some non-steroidal anti-inflammatory drugs (NSAIDs) are structural analogs of prostaglandins and NSAIDs attenuate heat nociception and mechanical allodynia in models of inflammatory and neuropathic pain, we investigated whether three widely used NSAIDs (diclofenac, ketorolac, and xefocam) affect thermal and mechanical hyperalgesia following the activation of TRPA1 and TRPV1 channels. We measured nociceptive thermal paw withdrawal latencies and mechanical thresholds bilaterally at various time points following intraplantar injection of the TRPA1 agonists, cinnamaldehyde (CA) and allyl isothiocyanate (AITC) or the TRPV1 agonist capsaicin, or vehicle. When pretreated with vehicle, intraplantar injection of CA, AITC and capsaicin each resulted in significant decreases in thermal withdrawal latency and mechanical threshold in the ipsilateral hindpaw that did not return to baseline for more than 2h. To test effects of NSAIDS either diclofenac, ketorolac or xefocam was pre-injected in the same hindpaw 35min prior to CA, AITC or capsaicin. Pretreatment with each of the three NSAIDs produced strong antinociceptive and antihyperalgesic effects lasting approximately 60min. Thus, we show for the first time that local administration of NSAIDs reduces thermal and mechanical hyperalgesia following TRPA1 or TRPV1 activation. SN - 1950-6007 UR - https://www.unboundmedicine.com/medline/citation/29102918/Non_steroidal_anti_inflammatory_drugs_attenuate_agonist_evoked_activation_of_transient_receptor_potential_channels_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0753-3322(17)34298-1 DB - PRIME DP - Unbound Medicine ER -