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Cyclodextrin-based oral dissolving films formulation of taste-masked meloxicam.
Pharm Dev Technol. 2018 Jun; 23(5):530-539.PD

Abstract

This work deals with fast-dissolving drug delivery systems of meloxicam (MX) derived from electrospun polyvinylpyrrolidone (PVP)/2-hydroxypropyl-β-cyclodextrin (HPβCD) nanofiber mats. Electrospinning of solutions with different solvent systems [dimethylformamide (DMF) and ethyl alcohol (EtOH)] was performed. Prepared films were evaluated for morphology, physical, and mechanical properties. MX content, dissolving time, MX release, and cytotoxicity of films were investigated. In vivo studies were also performed in healthy human volunteers. The results showed that MX/HPβCD complexes improved the solubility of MX. PVP also increased MX solubility and the stability of MX/HPβCD complexes. Films were successfully prepared by two solvent systems with fiber in the nanometer range. MX was well incorporated into the films (100% efficiency). The X-ray patterns and DSC experiment indicated an amorphous form of MX. A fast disintegration time and burst release of MX was obtained from EtOH system. Cytotoxicity testing of the films produced by EtOH system proved safer than the DMF system. In vivo studies revealed that films rapidly dissolved in the mouth and had a less bitter taste than MX. These results suggest that electospun films from EtOH system may be a good candidate for fast-dissolving drug delivery systems to increase palatability of dosage forms.

Authors+Show Affiliations

a Department of Pharmaceutical Technology, Faculty of Pharmacy , Rangsit University , Pathum Thani , Thailand.b Department of Pharmaceutical Technology, Faculty of Pharmacy , Silpakorn University , Nakhon Pathom , Thailand.c Department of Oral Diagnosis Faculty of Dentistry , Naresuan University , Phitsanulok , Thailand.b Department of Pharmaceutical Technology, Faculty of Pharmacy , Silpakorn University , Nakhon Pathom , Thailand.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29103353

Citation

Samprasit, Wipada, et al. "Cyclodextrin-based Oral Dissolving Films Formulation of Taste-masked Meloxicam." Pharmaceutical Development and Technology, vol. 23, no. 5, 2018, pp. 530-539.
Samprasit W, Akkaramongkolporn P, Kaomongkolgit R, et al. Cyclodextrin-based oral dissolving films formulation of taste-masked meloxicam. Pharm Dev Technol. 2018;23(5):530-539.
Samprasit, W., Akkaramongkolporn, P., Kaomongkolgit, R., & Opanasopit, P. (2018). Cyclodextrin-based oral dissolving films formulation of taste-masked meloxicam. Pharmaceutical Development and Technology, 23(5), 530-539. https://doi.org/10.1080/10837450.2017.1401636
Samprasit W, et al. Cyclodextrin-based Oral Dissolving Films Formulation of Taste-masked Meloxicam. Pharm Dev Technol. 2018;23(5):530-539. PubMed PMID: 29103353.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cyclodextrin-based oral dissolving films formulation of taste-masked meloxicam. AU - Samprasit,Wipada, AU - Akkaramongkolporn,Prasert, AU - Kaomongkolgit,Ruchadaporn, AU - Opanasopit,Praneet, Y1 - 2017/12/07/ PY - 2017/11/7/pubmed PY - 2018/9/20/medline PY - 2017/11/7/entrez KW - Oral dissolving films KW - dimethylformamide KW - electrospinning KW - ethyl alcohol KW - meloxicam SP - 530 EP - 539 JF - Pharmaceutical development and technology JO - Pharm Dev Technol VL - 23 IS - 5 N2 - This work deals with fast-dissolving drug delivery systems of meloxicam (MX) derived from electrospun polyvinylpyrrolidone (PVP)/2-hydroxypropyl-β-cyclodextrin (HPβCD) nanofiber mats. Electrospinning of solutions with different solvent systems [dimethylformamide (DMF) and ethyl alcohol (EtOH)] was performed. Prepared films were evaluated for morphology, physical, and mechanical properties. MX content, dissolving time, MX release, and cytotoxicity of films were investigated. In vivo studies were also performed in healthy human volunteers. The results showed that MX/HPβCD complexes improved the solubility of MX. PVP also increased MX solubility and the stability of MX/HPβCD complexes. Films were successfully prepared by two solvent systems with fiber in the nanometer range. MX was well incorporated into the films (100% efficiency). The X-ray patterns and DSC experiment indicated an amorphous form of MX. A fast disintegration time and burst release of MX was obtained from EtOH system. Cytotoxicity testing of the films produced by EtOH system proved safer than the DMF system. In vivo studies revealed that films rapidly dissolved in the mouth and had a less bitter taste than MX. These results suggest that electospun films from EtOH system may be a good candidate for fast-dissolving drug delivery systems to increase palatability of dosage forms. SN - 1097-9867 UR - https://www.unboundmedicine.com/medline/citation/29103353/Cyclodextrin_based_oral_dissolving_films_formulation_of_taste_masked_meloxicam_ L2 - http://www.tandfonline.com/doi/full/10.1080/10837450.2017.1401636 DB - PRIME DP - Unbound Medicine ER -