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Dasatinib-induced Seborrheic Dermatitis-like Eruption.
J Clin Aesthet Dermatol. 2017 Jul; 10(7):23-27.JC

Abstract

Dasatinib is an oral tyrosine kinase inhibitor approved for imatinib-resistant chronic myelogenous leukemia. It has been investigated in treating other neoplasms, including non-small-cell lung cancer and a subset of melanomas. Seborrheic dermatitis is characterized by erythematous patches or plaques with scaling typically affecting the external ear, glabella, hair-bearing areas of the face, nasolabial fold, and scalp. Antitumor agents are often associated with mucocutaneous side effects, including seborrheic dermatitis. We describe the case of a 79-year-old woman with a history of sinonasal melanoma who developed a seborrheic dermatitis-like eruption while taking dasatinib. We also review the molecular abnormalities associated with melanoma, summarize the mucocutaneous side effects of dasatinib, and list the other antineoplastic agents associated with a seborrheic dermatitis-like eruption.

Authors+Show Affiliations

Dr. Riahi is with DermSurgery Associates, Houston, Texas.Dr. Riahi is with DermSurgery Associates, Houston, Texas.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

29104720

Citation

Riahi, Ryan R., and Philip R. Cohen. "Dasatinib-induced Seborrheic Dermatitis-like Eruption." The Journal of Clinical and Aesthetic Dermatology, vol. 10, no. 7, 2017, pp. 23-27.
Riahi RR, Cohen PR. Dasatinib-induced Seborrheic Dermatitis-like Eruption. J Clin Aesthet Dermatol. 2017;10(7):23-27.
Riahi, R. R., & Cohen, P. R. (2017). Dasatinib-induced Seborrheic Dermatitis-like Eruption. The Journal of Clinical and Aesthetic Dermatology, 10(7), 23-27.
Riahi RR, Cohen PR. Dasatinib-induced Seborrheic Dermatitis-like Eruption. J Clin Aesthet Dermatol. 2017;10(7):23-27. PubMed PMID: 29104720.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dasatinib-induced Seborrheic Dermatitis-like Eruption. AU - Riahi,Ryan R, AU - Cohen,Philip R, Y1 - 2017/07/01/ PY - 2017/11/7/entrez PY - 2017/11/7/pubmed PY - 2017/11/7/medline KW - Antineoplastic KW - BRAF KW - c-kit KW - chemotherapy KW - cutaneous KW - dasatinib KW - melanoma KW - mucocutaneous KW - mucosal KW - seborrheic dermatitis KW - side effect KW - tyrosine kinase inhibitors SP - 23 EP - 27 JF - The Journal of clinical and aesthetic dermatology JO - J Clin Aesthet Dermatol VL - 10 IS - 7 N2 - Dasatinib is an oral tyrosine kinase inhibitor approved for imatinib-resistant chronic myelogenous leukemia. It has been investigated in treating other neoplasms, including non-small-cell lung cancer and a subset of melanomas. Seborrheic dermatitis is characterized by erythematous patches or plaques with scaling typically affecting the external ear, glabella, hair-bearing areas of the face, nasolabial fold, and scalp. Antitumor agents are often associated with mucocutaneous side effects, including seborrheic dermatitis. We describe the case of a 79-year-old woman with a history of sinonasal melanoma who developed a seborrheic dermatitis-like eruption while taking dasatinib. We also review the molecular abnormalities associated with melanoma, summarize the mucocutaneous side effects of dasatinib, and list the other antineoplastic agents associated with a seborrheic dermatitis-like eruption. SN - 1941-2789 UR - https://www.unboundmedicine.com/medline/citation/29104720/Dasatinib_induced_Seborrheic_Dermatitis_like_Eruption_ DB - PRIME DP - Unbound Medicine ER -
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