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Milk and other dairy foods in relation to prostate cancer recurrence: Data from the cancer of the prostate strategic urologic research endeavor (CaPSURE™).
Prostate 2018; 78(1):32-39P

Abstract

BACKGROUND

High-fat dairy, particularly whole milk, in healthy men may increase risk of aggressive prostate cancer. However, data are limited regarding dairy after prostate cancer diagnosis.

METHOD

We conducted a prospective study among 1334 men with non-metastatic prostate cancer in the Cancer of the Prostate Strategic Urologic Research Endeavor. Men answered a food frequency questionnaire in 2004-2005 (median 2 years after diagnosis) and were followed until 2016 for recurrence, defined as: prostate cancer death, bone metastases, biochemical recurrence, or secondary treatment. Multivariate Cox proportional hazards regression was used to calculate hazards ratios (HR) and 95% confidence intervals (CI) for associations between whole and low-fat milk; total, high-fat, and low-fat dairy; and other dairy items and risk of recurrence.

RESULTS

During a median follow-up of 8 years, we observed 137 events. Men who consumed >4 servings/week versus 0-3 servings/month of whole milk had an 73% increased risk of recurrence (HR: 1.73; 95%CI: 1.00, 2.98; P-value = 0.04). Body mass index (BMI) modified the association (P-interaction = 0.01). Among men with a BMI ≥27 kg/m2 , >4 servings/week versus 0-3 servings/month of whole milk was associated with a 3-fold higher risk of recurrence (HR: 2.96; 95%CI: 1.58, 5.54; P-value < 0.001). No association was seen in men with BMI <27 kg/m2 . Low-fat milk and other dairy foods were not associated with recurrence.

CONCLUSION

In conclusion, whole milk consumption after prostate cancer diagnosis was associated with increased risk of recurrence, particularly among very overweight or obese men. Men with prostate cancer who choose to drink milk should select non-fat or low-fat options.

Authors+Show Affiliations

Duke University School of Medicine, Durham, North Carolina. Department of Urology, University of California San Francisco, San Francisco, California.Department of Urology, University of California San Francisco, San Francisco, California. Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts.Department of Urology, University of California San Francisco, San Francisco, California.Department of Urology, University of California San Francisco, San Francisco, California.Department of Urology, University of California San Francisco, San Francisco, California.Department of Urology, University of California San Francisco, San Francisco, California. Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California.Department of Urology, University of California San Francisco, San Francisco, California. Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29105845

Citation

Tat, David, et al. "Milk and Other Dairy Foods in Relation to Prostate Cancer Recurrence: Data From the Cancer of the Prostate Strategic Urologic Research Endeavor (CaPSURE™)." The Prostate, vol. 78, no. 1, 2018, pp. 32-39.
Tat D, Kenfield SA, Cowan JE, et al. Milk and other dairy foods in relation to prostate cancer recurrence: Data from the cancer of the prostate strategic urologic research endeavor (CaPSURE™). Prostate. 2018;78(1):32-39.
Tat, D., Kenfield, S. A., Cowan, J. E., Broering, J. M., Carroll, P. R., Van Blarigan, E. L., & Chan, J. M. (2018). Milk and other dairy foods in relation to prostate cancer recurrence: Data from the cancer of the prostate strategic urologic research endeavor (CaPSURE™). The Prostate, 78(1), pp. 32-39. doi:10.1002/pros.23441.
Tat D, et al. Milk and Other Dairy Foods in Relation to Prostate Cancer Recurrence: Data From the Cancer of the Prostate Strategic Urologic Research Endeavor (CaPSURE™). Prostate. 2018;78(1):32-39. PubMed PMID: 29105845.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Milk and other dairy foods in relation to prostate cancer recurrence: Data from the cancer of the prostate strategic urologic research endeavor (CaPSURE™). AU - Tat,David, AU - Kenfield,Stacey A, AU - Cowan,Janet E, AU - Broering,Jeanette M, AU - Carroll,Peter R, AU - Van Blarigan,Erin L, AU - Chan,June M, Y1 - 2017/11/06/ PY - 2017/08/22/received PY - 2017/09/29/accepted PY - 2017/11/7/pubmed PY - 2017/12/21/medline PY - 2017/11/7/entrez KW - cancer survivorship KW - nutrition KW - whole milk SP - 32 EP - 39 JF - The Prostate JO - Prostate VL - 78 IS - 1 N2 - BACKGROUND: High-fat dairy, particularly whole milk, in healthy men may increase risk of aggressive prostate cancer. However, data are limited regarding dairy after prostate cancer diagnosis. METHOD: We conducted a prospective study among 1334 men with non-metastatic prostate cancer in the Cancer of the Prostate Strategic Urologic Research Endeavor. Men answered a food frequency questionnaire in 2004-2005 (median 2 years after diagnosis) and were followed until 2016 for recurrence, defined as: prostate cancer death, bone metastases, biochemical recurrence, or secondary treatment. Multivariate Cox proportional hazards regression was used to calculate hazards ratios (HR) and 95% confidence intervals (CI) for associations between whole and low-fat milk; total, high-fat, and low-fat dairy; and other dairy items and risk of recurrence. RESULTS: During a median follow-up of 8 years, we observed 137 events. Men who consumed >4 servings/week versus 0-3 servings/month of whole milk had an 73% increased risk of recurrence (HR: 1.73; 95%CI: 1.00, 2.98; P-value = 0.04). Body mass index (BMI) modified the association (P-interaction = 0.01). Among men with a BMI ≥27 kg/m2 , >4 servings/week versus 0-3 servings/month of whole milk was associated with a 3-fold higher risk of recurrence (HR: 2.96; 95%CI: 1.58, 5.54; P-value < 0.001). No association was seen in men with BMI <27 kg/m2 . Low-fat milk and other dairy foods were not associated with recurrence. CONCLUSION: In conclusion, whole milk consumption after prostate cancer diagnosis was associated with increased risk of recurrence, particularly among very overweight or obese men. Men with prostate cancer who choose to drink milk should select non-fat or low-fat options. SN - 1097-0045 UR - https://www.unboundmedicine.com/medline/citation/29105845/Milk_and_other_dairy_foods_in_relation_to_prostate_cancer_recurrence:_Data_from_the_cancer_of_the_prostate_strategic_urologic_research_endeavor__CaPSURE™__ L2 - https://doi.org/10.1002/pros.23441 DB - PRIME DP - Unbound Medicine ER -