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Diabetes based on 2-h plasma glucose among those classified as having prediabetes based on fasting plasma glucose or A1c.
Diab Vasc Dis Res. 2018 01; 15(1):46-54.DV

Abstract

OBJECTIVE

Determine the prevalence of diabetes using 2-h plasma glucose among people who otherwise would be categorized as having prediabetes based on A1c and fasting glucose, and to determine whether those people were more likely to have cardiometabolic risk factors.

METHODS

Among 3644 adults with prediabetes based on A1c and fasting glucose in the 2005-2014 National Health and Nutrition Examination Survey, a cross-sectional survey of the US general population, we estimated the percentage who would be categorized as having diabetes based on having a 2-h plasma glucose ⩾200 mg/dL. We calculated odds ratios of cardiometabolic risk factors associated with having 2-h plasma glucose ⩾200 mg/dL.

RESULTS

A total of 6.9% would be categorized as having diabetes based on 2-h plasma glucose. The adjusted odds ratios (95% confidence interval) associated with having 2-h plasma glucose ⩾200 mg/dL were significant for total hypertension (2.06, 1.35-3.14), high triglycerides (1.64, 1.10-2.44), low high-density lipoprotein cholesterol (1.55, 1.01-2.39), albuminuria (2.05, 1.33-3.14) and elevated alanine aminotransferase (1.78, 1.09-2.91), but not for other cardiometabolic risk factors.

CONCLUSION

A total of 6.9% of people categorized as having prediabetes based on A1c and fasting glucose would be categorized as having diabetes based on 2-h plasma glucose. They were more likely to have hypertension, high triglycerides, low high-density lipoprotein cholesterol, albuminuria and elevated alanine aminotransferase.

Authors+Show Affiliations

1 Social & Scientific Systems, Inc., Silver Spring, MD, USA.2 Westat, Rockville, MD, USA.3 National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

29113512

Citation

Menke, Andy, et al. "Diabetes Based On 2-h Plasma Glucose Among Those Classified as Having Prediabetes Based On Fasting Plasma Glucose or A1c." Diabetes & Vascular Disease Research, vol. 15, no. 1, 2018, pp. 46-54.
Menke A, Rust KF, Cowie CC. Diabetes based on 2-h plasma glucose among those classified as having prediabetes based on fasting plasma glucose or A1c. Diab Vasc Dis Res. 2018;15(1):46-54.
Menke, A., Rust, K. F., & Cowie, C. C. (2018). Diabetes based on 2-h plasma glucose among those classified as having prediabetes based on fasting plasma glucose or A1c. Diabetes & Vascular Disease Research, 15(1), 46-54. https://doi.org/10.1177/1479164117739316
Menke A, Rust KF, Cowie CC. Diabetes Based On 2-h Plasma Glucose Among Those Classified as Having Prediabetes Based On Fasting Plasma Glucose or A1c. Diab Vasc Dis Res. 2018;15(1):46-54. PubMed PMID: 29113512.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diabetes based on 2-h plasma glucose among those classified as having prediabetes based on fasting plasma glucose or A1c. AU - Menke,Andy, AU - Rust,Keith F, AU - Cowie,Catherine C, Y1 - 2017/11/07/ PY - 2017/11/9/pubmed PY - 2018/1/6/medline PY - 2017/11/9/entrez KW - Oral glucose tolerance test KW - cardiovascular risk factors KW - diagnostic criteria SP - 46 EP - 54 JF - Diabetes & vascular disease research JO - Diab Vasc Dis Res VL - 15 IS - 1 N2 - OBJECTIVE: Determine the prevalence of diabetes using 2-h plasma glucose among people who otherwise would be categorized as having prediabetes based on A1c and fasting glucose, and to determine whether those people were more likely to have cardiometabolic risk factors. METHODS: Among 3644 adults with prediabetes based on A1c and fasting glucose in the 2005-2014 National Health and Nutrition Examination Survey, a cross-sectional survey of the US general population, we estimated the percentage who would be categorized as having diabetes based on having a 2-h plasma glucose ⩾200 mg/dL. We calculated odds ratios of cardiometabolic risk factors associated with having 2-h plasma glucose ⩾200 mg/dL. RESULTS: A total of 6.9% would be categorized as having diabetes based on 2-h plasma glucose. The adjusted odds ratios (95% confidence interval) associated with having 2-h plasma glucose ⩾200 mg/dL were significant for total hypertension (2.06, 1.35-3.14), high triglycerides (1.64, 1.10-2.44), low high-density lipoprotein cholesterol (1.55, 1.01-2.39), albuminuria (2.05, 1.33-3.14) and elevated alanine aminotransferase (1.78, 1.09-2.91), but not for other cardiometabolic risk factors. CONCLUSION: A total of 6.9% of people categorized as having prediabetes based on A1c and fasting glucose would be categorized as having diabetes based on 2-h plasma glucose. They were more likely to have hypertension, high triglycerides, low high-density lipoprotein cholesterol, albuminuria and elevated alanine aminotransferase. SN - 1752-8984 UR - https://www.unboundmedicine.com/medline/citation/29113512/Diabetes_based_on_2_h_plasma_glucose_among_those_classified_as_having_prediabetes_based_on_fasting_plasma_glucose_or_A1c_ L2 - https://journals.sagepub.com/doi/10.1177/1479164117739316?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -