Tags

Type your tag names separated by a space and hit enter

Effect of aerobic exercise on hippocampal volume in humans: A systematic review and meta-analysis.
Neuroimage 2018; 166:230-238N

Abstract

Hippocampal volume increase in response to aerobic exercise has been consistently observed in animal models. However, the evidence from human studies is equivocal. We undertook a systematic review to identify all controlled trials examining the effect of aerobic exercise on the hippocampal volumes in humans, and applied meta-analytic techniques to determine if aerobic exercise resulted in volumetric increases. We also sought to establish how volume changes differed in relation to unilateral measures of left/right hippocampal volume, and across the lifespan. A systematic search identified 4398 articles, of which 14 were eligible for inclusion in the primary analysis. A random-effects meta-analysis showed no significant effect of aerobic exercise on total hippocampal volume across the 737 participants. However, aerobic exercise had significant positive effects on left hippocampal volume in comparison to control conditions. Post-hoc analyses indicated effects were driven through exercise preventing the volumetric decreases which occur over time. These results provide meta-analytic evidence for exercise-induced volumetric retention in the left hippocampus. Aerobic exercise interventions may be useful for preventing age-related hippocampal deterioration and maintaining neuronal health.

Authors+Show Affiliations

NICM, School of Science and Health, University of Western Sydney, Australia; Division of Psychology and Mental Health, University of Manchester, UK. Electronic address: j.firth@westernsydney.edu.au.Physiotherapy Department, South London and Maudsley NHS Foundation Trust, UK; Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.KU Leuven Department of Rehabilitation Sciences, Leuven, Belgium; KU Leuven Department of Neurosciences, UPC KU Leuven, Belgium.Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; Centro Universitário La Salle, Canoas, Brazil.Sunshine Coast Mind and Neuroscience, Thompson Institute, University of the Sunshine Coast, Australia.School of Psychiatry, UNSW, Sydney, Australia; Black Dog Institute, Randwick, Australia.School of Psychiatry, UNSW, Sydney, Australia; Schizophrenia Research Unit, Ingham Institute of Applied Medical Research, Liverpool, Australia.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

29113943

Citation

Firth, Joseph, et al. "Effect of Aerobic Exercise On Hippocampal Volume in Humans: a Systematic Review and Meta-analysis." NeuroImage, vol. 166, 2018, pp. 230-238.
Firth J, Stubbs B, Vancampfort D, et al. Effect of aerobic exercise on hippocampal volume in humans: A systematic review and meta-analysis. Neuroimage. 2018;166:230-238.
Firth, J., Stubbs, B., Vancampfort, D., Schuch, F., Lagopoulos, J., Rosenbaum, S., & Ward, P. B. (2018). Effect of aerobic exercise on hippocampal volume in humans: A systematic review and meta-analysis. NeuroImage, 166, pp. 230-238. doi:10.1016/j.neuroimage.2017.11.007.
Firth J, et al. Effect of Aerobic Exercise On Hippocampal Volume in Humans: a Systematic Review and Meta-analysis. Neuroimage. 2018 02 1;166:230-238. PubMed PMID: 29113943.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of aerobic exercise on hippocampal volume in humans: A systematic review and meta-analysis. AU - Firth,Joseph, AU - Stubbs,Brendon, AU - Vancampfort,Davy, AU - Schuch,Felipe, AU - Lagopoulos,Jim, AU - Rosenbaum,Simon, AU - Ward,Philip B, Y1 - 2017/11/04/ PY - 2017/04/27/received PY - 2017/09/18/revised PY - 2017/11/02/accepted PY - 2017/11/9/pubmed PY - 2018/12/12/medline PY - 2017/11/9/entrez KW - Hippocampus KW - Neurodegeneration KW - Neurogenesis KW - Physical activity KW - Plasticity KW - Resistance SP - 230 EP - 238 JF - NeuroImage JO - Neuroimage VL - 166 N2 - Hippocampal volume increase in response to aerobic exercise has been consistently observed in animal models. However, the evidence from human studies is equivocal. We undertook a systematic review to identify all controlled trials examining the effect of aerobic exercise on the hippocampal volumes in humans, and applied meta-analytic techniques to determine if aerobic exercise resulted in volumetric increases. We also sought to establish how volume changes differed in relation to unilateral measures of left/right hippocampal volume, and across the lifespan. A systematic search identified 4398 articles, of which 14 were eligible for inclusion in the primary analysis. A random-effects meta-analysis showed no significant effect of aerobic exercise on total hippocampal volume across the 737 participants. However, aerobic exercise had significant positive effects on left hippocampal volume in comparison to control conditions. Post-hoc analyses indicated effects were driven through exercise preventing the volumetric decreases which occur over time. These results provide meta-analytic evidence for exercise-induced volumetric retention in the left hippocampus. Aerobic exercise interventions may be useful for preventing age-related hippocampal deterioration and maintaining neuronal health. SN - 1095-9572 UR - https://www.unboundmedicine.com/medline/citation/29113943/Effect_of_aerobic_exercise_on_hippocampal_volume_in_humans:_A_systematic_review_and_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1053-8119(17)30913-8 DB - PRIME DP - Unbound Medicine ER -