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Association of Resilience With Depression and Health-Related Quality of Life for Patients With Hidradenitis Suppurativa.
JAMA Dermatol 2017; 153(12):1263-1269JD

Abstract

Importance

Hidradenitis suppurativa (HS) places a significant burden on the health-related quality of life (HRQOL) of patients, many of whom have depression. Resilience can play a role in mitigating the negative stressors, such as the symptoms of HS, on patients' mental health.

Objective

To investigate the correlation among resilience, depression, and HRQOL for patients with HS.

Design, Setting, and Participants

This cross-sectional survey study of 154 patients from 2 referral centers in the United States and in Denmark was conducted from June 1, 2016, to March 31, 2017. Patients were considered eligible if they were 18 years or older and had a visit for HS at 1 of the 2 referral centers in the past 2 years (from January 1, 2014, through December 31, 2016). Patients were excluded if they declined to participate, could not read or write in English or Danish, or had a cognitive disability that would preclude their understanding of the survey questions.

Main Outcomes and Measures

The survey instrument included 4 questionnaires: (1) a sociodemographic and clinical characteristics questionnaire, (2) the Brief Resilient Coping Scale, (3) the Hospital Anxiety and Depression Scale, and (4) the Dermatology Life Quality Index. The main outcome of interest was the HRQOL as measured by the Dermatology Life Quality Index.

Results

All 154 patients submitted a completed survey. The mean (SD) age of the participants was 40.93 (13.5) years; most participants were women (130 [84.4%]), and most participants self-identified as white (139 [90.2%]). The rate of depression among the patients in this study was comparable to those reported in previous studies; 55 patients (35.7%) were classified as having depression, and 32 patients (20.8%) had borderline depressive symptoms. Patient-rated HS severity and the depression score each independently estimated 27% and 10% of variation in HRQOL, respectively. The interaction term for resilience and depression was significant, indicating that resilience moderates depression. Analysis of the mediation effects of resilience was not significant, indicating that resilience did not mediate the association between depressive symptoms and HRQOL. The resilience score was significantly associated with depressive symptoms (regression coefficient a = -0.21; P < .001), and the depressive symptoms score (c = 0.637; P < .001) was significantly associated with lower HRQOL (c' = 0.644; P < .001). However, both the direct association (b = 0.033; P = .86) and the indirect association (a × b = 0.007; P = .87) of resilience with HRQOL were not significant.

Conclusions and Relevance

Patients with higher resilience levels experienced a smaller decrease in HRQOL as depressive symptoms increased. Because the findings suggest that resilience can be taught, there is an opportunity to develop a resiliency training program and investigate its role in stress levels and depressive symptoms, as well as in HRQOL and disease activity.

Authors+Show Affiliations

Department of Dermatology, Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania.Department of Dermatology, Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania.Department of Dermatology, Zealand University Hospital, Roskilde, Denmark. Health Sciences Faculty, University of Copenhagen, Copenhagen, Denmark.Department of Dermatology, Zealand University Hospital, Roskilde, Denmark. Health Sciences Faculty, University of Copenhagen, Copenhagen, Denmark.

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

29117300

Citation

Kirby, Joslyn S., et al. "Association of Resilience With Depression and Health-Related Quality of Life for Patients With Hidradenitis Suppurativa." JAMA Dermatology, vol. 153, no. 12, 2017, pp. 1263-1269.
Kirby JS, Butt M, Esmann S, et al. Association of Resilience With Depression and Health-Related Quality of Life for Patients With Hidradenitis Suppurativa. JAMA Dermatol. 2017;153(12):1263-1269.
Kirby, J. S., Butt, M., Esmann, S., & Jemec, G. B. E. (2017). Association of Resilience With Depression and Health-Related Quality of Life for Patients With Hidradenitis Suppurativa. JAMA Dermatology, 153(12), pp. 1263-1269. doi:10.1001/jamadermatol.2017.3596.
Kirby JS, et al. Association of Resilience With Depression and Health-Related Quality of Life for Patients With Hidradenitis Suppurativa. JAMA Dermatol. 2017 12 1;153(12):1263-1269. PubMed PMID: 29117300.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of Resilience With Depression and Health-Related Quality of Life for Patients With Hidradenitis Suppurativa. AU - Kirby,Joslyn S, AU - Butt,Melissa, AU - Esmann,Solveig, AU - Jemec,Gregor B E, PY - 2017/11/9/pubmed PY - 2017/12/23/medline PY - 2017/11/9/entrez SP - 1263 EP - 1269 JF - JAMA dermatology JO - JAMA Dermatol VL - 153 IS - 12 N2 - Importance: Hidradenitis suppurativa (HS) places a significant burden on the health-related quality of life (HRQOL) of patients, many of whom have depression. Resilience can play a role in mitigating the negative stressors, such as the symptoms of HS, on patients' mental health. Objective: To investigate the correlation among resilience, depression, and HRQOL for patients with HS. Design, Setting, and Participants: This cross-sectional survey study of 154 patients from 2 referral centers in the United States and in Denmark was conducted from June 1, 2016, to March 31, 2017. Patients were considered eligible if they were 18 years or older and had a visit for HS at 1 of the 2 referral centers in the past 2 years (from January 1, 2014, through December 31, 2016). Patients were excluded if they declined to participate, could not read or write in English or Danish, or had a cognitive disability that would preclude their understanding of the survey questions. Main Outcomes and Measures: The survey instrument included 4 questionnaires: (1) a sociodemographic and clinical characteristics questionnaire, (2) the Brief Resilient Coping Scale, (3) the Hospital Anxiety and Depression Scale, and (4) the Dermatology Life Quality Index. The main outcome of interest was the HRQOL as measured by the Dermatology Life Quality Index. Results: All 154 patients submitted a completed survey. The mean (SD) age of the participants was 40.93 (13.5) years; most participants were women (130 [84.4%]), and most participants self-identified as white (139 [90.2%]). The rate of depression among the patients in this study was comparable to those reported in previous studies; 55 patients (35.7%) were classified as having depression, and 32 patients (20.8%) had borderline depressive symptoms. Patient-rated HS severity and the depression score each independently estimated 27% and 10% of variation in HRQOL, respectively. The interaction term for resilience and depression was significant, indicating that resilience moderates depression. Analysis of the mediation effects of resilience was not significant, indicating that resilience did not mediate the association between depressive symptoms and HRQOL. The resilience score was significantly associated with depressive symptoms (regression coefficient a = -0.21; P < .001), and the depressive symptoms score (c = 0.637; P < .001) was significantly associated with lower HRQOL (c' = 0.644; P < .001). However, both the direct association (b = 0.033; P = .86) and the indirect association (a × b = 0.007; P = .87) of resilience with HRQOL were not significant. Conclusions and Relevance: Patients with higher resilience levels experienced a smaller decrease in HRQOL as depressive symptoms increased. Because the findings suggest that resilience can be taught, there is an opportunity to develop a resiliency training program and investigate its role in stress levels and depressive symptoms, as well as in HRQOL and disease activity. SN - 2168-6084 UR - https://www.unboundmedicine.com/medline/citation/29117300/Association_of_Resilience_With_Depression_and_Health_Related_Quality_of_Life_for_Patients_With_Hidradenitis_Suppurativa_ L2 - https://jamanetwork.com/journals/jamadermatology/fullarticle/10.1001/jamadermatol.2017.3596 DB - PRIME DP - Unbound Medicine ER -