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The Effect of Hypolipidemic Agents on Thyroid Autoimmunity in Women with Hashimoto's Thyroiditis Treated with Levothyroxine and Selenomethionine.
Exp Clin Endocrinol Diabetes 2018; 126(5):321-326EC

Abstract

BACKGROUND

Levothyroxine and selenomethionine were found to reduce thyroid antibody titers in patients with Hashimoto's thyroiditis. The same effect was produced by intensive statin therapy. The aim of the present study was to assess whether hypolipidemic agents modulate the impact of thyroid hormone supplementation and selenomethionine on thyroid autoimmunity.

METHODS

The study included 62 women with Hashimoto's thyroiditis treated for at least 6 months with levothyroxine and selenomethionine. On the basis of plasma lipids, women were divided into three groups: women with isolated hypercholesterolemia (group A; n=20), women with isolated hypertriglyceridemia (group B; n=17), and women with normal plasma lipids (group C; n=25). Group A were then treated with atorvastatin (20 mg daily), while group B received micronized fenofibrate (200 mg daily). Serum titers of thyroid peroxidase and thyroglobulin antibodies, as well as serum levels of thyrotropin, free thyroxine and free triiodothyronine were measured at the beginning of the study and 6 months later.

RESULTS

Fenofibrate decreased triglycerides and increased HDL cholesterol, while simvastatin decreased total and LDL cholesterol. Fenofibrate reduced titers of thyroid peroxidase and, to a lesser extent, thyroglobulin antibodies. Atorvastatin tended to increase thyroid peroxidase antibodies. No changes in thyrotropin, free thyroxine and free triiodothyronine were observed in any treatment group. Fenofibrate-induced changes in thyroid antibody titers correlated with baseline antibody titers, as well as with treatment-induced changes in HDL cholesterol and insulin sensitivity.

CONCLUSIONS

The obtained results indicate that only fibrates may potentiate the effect of selenomethionine and levothyroxine on thyroid autoimmunity in women.

Authors+Show Affiliations

Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29117614

Citation

Krysiak, Robert, et al. "The Effect of Hypolipidemic Agents On Thyroid Autoimmunity in Women With Hashimoto's Thyroiditis Treated With Levothyroxine and Selenomethionine." Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association, vol. 126, no. 5, 2018, pp. 321-326.
Krysiak R, Szkróbka W, Okopień B. The Effect of Hypolipidemic Agents on Thyroid Autoimmunity in Women with Hashimoto's Thyroiditis Treated with Levothyroxine and Selenomethionine. Exp Clin Endocrinol Diabetes. 2018;126(5):321-326.
Krysiak, R., Szkróbka, W., & Okopień, B. (2018). The Effect of Hypolipidemic Agents on Thyroid Autoimmunity in Women with Hashimoto's Thyroiditis Treated with Levothyroxine and Selenomethionine. Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association, 126(5), pp. 321-326. doi:10.1055/s-0043-120342.
Krysiak R, Szkróbka W, Okopień B. The Effect of Hypolipidemic Agents On Thyroid Autoimmunity in Women With Hashimoto's Thyroiditis Treated With Levothyroxine and Selenomethionine. Exp Clin Endocrinol Diabetes. 2018;126(5):321-326. PubMed PMID: 29117614.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Effect of Hypolipidemic Agents on Thyroid Autoimmunity in Women with Hashimoto's Thyroiditis Treated with Levothyroxine and Selenomethionine. AU - Krysiak,Robert, AU - Szkróbka,Witold, AU - Okopień,Bogusław, Y1 - 2017/11/08/ PY - 2017/11/9/pubmed PY - 2018/10/3/medline PY - 2017/11/9/entrez SP - 321 EP - 326 JF - Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association JO - Exp. Clin. Endocrinol. Diabetes VL - 126 IS - 5 N2 - BACKGROUND: Levothyroxine and selenomethionine were found to reduce thyroid antibody titers in patients with Hashimoto's thyroiditis. The same effect was produced by intensive statin therapy. The aim of the present study was to assess whether hypolipidemic agents modulate the impact of thyroid hormone supplementation and selenomethionine on thyroid autoimmunity. METHODS: The study included 62 women with Hashimoto's thyroiditis treated for at least 6 months with levothyroxine and selenomethionine. On the basis of plasma lipids, women were divided into three groups: women with isolated hypercholesterolemia (group A; n=20), women with isolated hypertriglyceridemia (group B; n=17), and women with normal plasma lipids (group C; n=25). Group A were then treated with atorvastatin (20 mg daily), while group B received micronized fenofibrate (200 mg daily). Serum titers of thyroid peroxidase and thyroglobulin antibodies, as well as serum levels of thyrotropin, free thyroxine and free triiodothyronine were measured at the beginning of the study and 6 months later. RESULTS: Fenofibrate decreased triglycerides and increased HDL cholesterol, while simvastatin decreased total and LDL cholesterol. Fenofibrate reduced titers of thyroid peroxidase and, to a lesser extent, thyroglobulin antibodies. Atorvastatin tended to increase thyroid peroxidase antibodies. No changes in thyrotropin, free thyroxine and free triiodothyronine were observed in any treatment group. Fenofibrate-induced changes in thyroid antibody titers correlated with baseline antibody titers, as well as with treatment-induced changes in HDL cholesterol and insulin sensitivity. CONCLUSIONS: The obtained results indicate that only fibrates may potentiate the effect of selenomethionine and levothyroxine on thyroid autoimmunity in women. SN - 1439-3646 UR - https://www.unboundmedicine.com/medline/citation/29117614/The_Effect_of_Hypolipidemic_Agents_on_Thyroid_Autoimmunity_in_Women_with_Hashimoto's_Thyroiditis_Treated_with_Levothyroxine_and_Selenomethionine_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0043-120342 DB - PRIME DP - Unbound Medicine ER -