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Minimizing nocebo effect: Pragmatic approach.
Avicenna J Med. 2017 Oct-Dec; 7(4):139-143.AJ

Abstract

The nocebo effect, the inverse of the placebo effect, is a well-established phenomenon, yet under-appreciated. It refers to nonpharmacological, harmful, or undesirable effects occurring after active or inactive therapy. The frequency of adverse events can dramatically increase by informing patients about the possible side effects of the treatment, and by negative expectations on the part of the patient. Patients who were told that they might experience sexual side effects after treatment with β-blocker drugs reported these symptoms between three and four times more often than patients in a control group who were not informed about these symptoms. Nocebo effect has been reported in several neurological diseases such as migraine, epilepsy, multiple sclerosis, Parkinson's disease and neuropathic pain, and in patients with depression. The investigation of the biological and theoretical underpinning of the nocebo phenomenon is at an early stage, and more research is required. Physicians need to be aware of the influence of nocebo phenomenon and be able to recognize it and minimize its effects.

Authors+Show Affiliations

Department of Medicine, King Fahd Armed Forces Hospital, Jeddah, Saudi Arabia.Department of Medical Ethics, International Medical Center, Jeddah, Saudi Arabia.Department of Cardiology, King Fahd Armed Forces Hospital, Jeddah, Saudi Arabia.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29119079

Citation

Chamsi-Pasha, Majed, et al. "Minimizing Nocebo Effect: Pragmatic Approach." Avicenna Journal of Medicine, vol. 7, no. 4, 2017, pp. 139-143.
Chamsi-Pasha M, Albar MA, Chamsi-Pasha H. Minimizing nocebo effect: Pragmatic approach. Avicenna J Med. 2017;7(4):139-143.
Chamsi-Pasha, M., Albar, M. A., & Chamsi-Pasha, H. (2017). Minimizing nocebo effect: Pragmatic approach. Avicenna Journal of Medicine, 7(4), 139-143. https://doi.org/10.4103/ajm.AJM_59_17
Chamsi-Pasha M, Albar MA, Chamsi-Pasha H. Minimizing Nocebo Effect: Pragmatic Approach. Avicenna J Med. 2017 Oct-Dec;7(4):139-143. PubMed PMID: 29119079.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Minimizing nocebo effect: Pragmatic approach. AU - Chamsi-Pasha,Majed, AU - Albar,Mohammed Ali, AU - Chamsi-Pasha,Hassan, PY - 2017/11/10/entrez PY - 2017/11/10/pubmed PY - 2017/11/10/medline KW - Drugs KW - medical ethics KW - nocebo KW - placebo KW - treatment SP - 139 EP - 143 JF - Avicenna journal of medicine JO - Avicenna J Med VL - 7 IS - 4 N2 - The nocebo effect, the inverse of the placebo effect, is a well-established phenomenon, yet under-appreciated. It refers to nonpharmacological, harmful, or undesirable effects occurring after active or inactive therapy. The frequency of adverse events can dramatically increase by informing patients about the possible side effects of the treatment, and by negative expectations on the part of the patient. Patients who were told that they might experience sexual side effects after treatment with β-blocker drugs reported these symptoms between three and four times more often than patients in a control group who were not informed about these symptoms. Nocebo effect has been reported in several neurological diseases such as migraine, epilepsy, multiple sclerosis, Parkinson's disease and neuropathic pain, and in patients with depression. The investigation of the biological and theoretical underpinning of the nocebo phenomenon is at an early stage, and more research is required. Physicians need to be aware of the influence of nocebo phenomenon and be able to recognize it and minimize its effects. SN - 2231-0770 UR - https://www.unboundmedicine.com/medline/citation/29119079/Minimizing_nocebo_effect:_Pragmatic_approach_ L2 - http://www.avicennajmed.com/article.asp?issn=2231-0770;year=2017;volume=7;issue=4;spage=139;epage=143;aulast=Chamsi-Pasha DB - PRIME DP - Unbound Medicine ER -
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