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Iron, copper, and zinc status: response to supplementation with zinc or zinc and iron in adult females.
Am J Clin Nutr 1989; 49(1):145-50AJ

Abstract

Response of iron, copper, and zinc status to supplementation with Zn or a combination of Zn and Fe was assessed in adult females in a 10-wk study. Group Z received 50 mg Zn/d as Zn gluconate; group F-Z received 50 mg Fe as ferrous sulfate monohydrate in addition to the Zn. For Group Z, serum ferritin, hematocrit, and erythrocyte Cu,Zn-superoxide dismutase (ESOD) were significantly lower (p less than 0.05) after 10 wk supplementation compared with pretreatment levels. Serum Zn increased (p less than 0.01) but no change occurred in serum ceruloplasmin, hemoglobin, or salivary sediment Zn with treatment. For Group F-Z ESOD decreased with treatment as did salivary sediment Zn (p less than 0.05). Serum ferritin and serum Zn increased significantly, but hemoglobin, hematocrit, and ceruloplasmin were not affected by this treatment. Supplementation with Zn poses a risk to Fe and Cu status. Inclusion of Fe with Zn ameliorates the effect on Fe but not on Cu status.

Authors+Show Affiliations

Department of Food, Nutrition, Oklahoma State University, Stillwater.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

2912000

Citation

Yadrick, M K., et al. "Iron, Copper, and Zinc Status: Response to Supplementation With Zinc or Zinc and Iron in Adult Females." The American Journal of Clinical Nutrition, vol. 49, no. 1, 1989, pp. 145-50.
Yadrick MK, Kenney MA, Winterfeldt EA. Iron, copper, and zinc status: response to supplementation with zinc or zinc and iron in adult females. Am J Clin Nutr. 1989;49(1):145-50.
Yadrick, M. K., Kenney, M. A., & Winterfeldt, E. A. (1989). Iron, copper, and zinc status: response to supplementation with zinc or zinc and iron in adult females. The American Journal of Clinical Nutrition, 49(1), pp. 145-50.
Yadrick MK, Kenney MA, Winterfeldt EA. Iron, Copper, and Zinc Status: Response to Supplementation With Zinc or Zinc and Iron in Adult Females. Am J Clin Nutr. 1989;49(1):145-50. PubMed PMID: 2912000.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Iron, copper, and zinc status: response to supplementation with zinc or zinc and iron in adult females. AU - Yadrick,M K, AU - Kenney,M A, AU - Winterfeldt,E A, PY - 1989/1/1/pubmed PY - 1989/1/1/medline PY - 1989/1/1/entrez SP - 145 EP - 50 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 49 IS - 1 N2 - Response of iron, copper, and zinc status to supplementation with Zn or a combination of Zn and Fe was assessed in adult females in a 10-wk study. Group Z received 50 mg Zn/d as Zn gluconate; group F-Z received 50 mg Fe as ferrous sulfate monohydrate in addition to the Zn. For Group Z, serum ferritin, hematocrit, and erythrocyte Cu,Zn-superoxide dismutase (ESOD) were significantly lower (p less than 0.05) after 10 wk supplementation compared with pretreatment levels. Serum Zn increased (p less than 0.01) but no change occurred in serum ceruloplasmin, hemoglobin, or salivary sediment Zn with treatment. For Group F-Z ESOD decreased with treatment as did salivary sediment Zn (p less than 0.05). Serum ferritin and serum Zn increased significantly, but hemoglobin, hematocrit, and ceruloplasmin were not affected by this treatment. Supplementation with Zn poses a risk to Fe and Cu status. Inclusion of Fe with Zn ameliorates the effect on Fe but not on Cu status. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/2912000/Iron_copper_and_zinc_status:_response_to_supplementation_with_zinc_or_zinc_and_iron_in_adult_females_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/49.1.145 DB - PRIME DP - Unbound Medicine ER -