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Breast cancer before age 45 and oral contraceptive use: new findings.
Am J Epidemiol 1989; 129(2):269-80AJ

Abstract

The relation between the risk of breast cancer before 45 years of age and oral contraceptive use was examined in a case-control study conducted in New York, Philadelphia, Baltimore, and Boston from 1983 to 1986 of 407 patients with breast cancer and 424 controls. With allowance for confounding, for ever use, the multivariate relative risk estimate was 2.0 (95% confidence interval (CI), 1.4-2.9). For less than 10 years of use, the estimate approximated 2.0 in all categories of duration, including less than three months; for 10 or more years of use it was 4.1 (95% CI, 1.8-9.3). The association was apparent in virtually all subgroups examined, including younger and older women, and women at low and high underlying risk of breast cancer. Contrary to some previous reports, the association was not stronger for use before a first term pregnancy or at an early age. The results suggest that oral contraceptive users, particularly those with very long durations of use, may be at increased risk of breast cancer. However, information bias, particularly for short-term use, could not be ruled out. There may also have been selection bias if oral contraceptive users were under more intensive medical surveillance. It has not been possible to reconcile the findings of the various studies to date, including the authors' earlier results showing no association. The latter results were derived from data collected using methods almost identical to those used in the present study.

Authors+Show Affiliations

Slone Epidemiology Unit, School of Public Health, Boston University School of Medicine, Brookline, MA 02146.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2912040

Citation

Miller, D R., et al. "Breast Cancer Before Age 45 and Oral Contraceptive Use: New Findings." American Journal of Epidemiology, vol. 129, no. 2, 1989, pp. 269-80.
Miller DR, Rosenberg L, Kaufman DW, et al. Breast cancer before age 45 and oral contraceptive use: new findings. Am J Epidemiol. 1989;129(2):269-80.
Miller, D. R., Rosenberg, L., Kaufman, D. W., Stolley, P., Warshauer, M. E., & Shapiro, S. (1989). Breast cancer before age 45 and oral contraceptive use: new findings. American Journal of Epidemiology, 129(2), pp. 269-80.
Miller DR, et al. Breast Cancer Before Age 45 and Oral Contraceptive Use: New Findings. Am J Epidemiol. 1989;129(2):269-80. PubMed PMID: 2912040.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Breast cancer before age 45 and oral contraceptive use: new findings. AU - Miller,D R, AU - Rosenberg,L, AU - Kaufman,D W, AU - Stolley,P, AU - Warshauer,M E, AU - Shapiro,S, PY - 1989/2/1/pubmed PY - 1989/2/1/medline PY - 1989/2/1/entrez KW - Age Factors KW - Americas KW - Biology KW - Breast Cancer--etiology KW - Cancer KW - Comparative Studies KW - Contraception KW - Contraceptive Methods--side effects KW - Data Analysis KW - Demographic Factors KW - Developed Countries KW - Diseases KW - Error Sources KW - Family Planning KW - Longterm Effects KW - Maryland KW - Massachusetts KW - Measurement KW - Multivariate Analysis KW - Neoplasms KW - New York KW - North America KW - Northern America KW - Oral Contraceptives--side effects KW - Pennsylvania KW - Population KW - Population Characteristics KW - Population Dynamics KW - Research Methodology KW - Risk Factors KW - Statistical Regression KW - Studies KW - Time Factors KW - United States SP - 269 EP - 80 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 129 IS - 2 N2 - The relation between the risk of breast cancer before 45 years of age and oral contraceptive use was examined in a case-control study conducted in New York, Philadelphia, Baltimore, and Boston from 1983 to 1986 of 407 patients with breast cancer and 424 controls. With allowance for confounding, for ever use, the multivariate relative risk estimate was 2.0 (95% confidence interval (CI), 1.4-2.9). For less than 10 years of use, the estimate approximated 2.0 in all categories of duration, including less than three months; for 10 or more years of use it was 4.1 (95% CI, 1.8-9.3). The association was apparent in virtually all subgroups examined, including younger and older women, and women at low and high underlying risk of breast cancer. Contrary to some previous reports, the association was not stronger for use before a first term pregnancy or at an early age. The results suggest that oral contraceptive users, particularly those with very long durations of use, may be at increased risk of breast cancer. However, information bias, particularly for short-term use, could not be ruled out. There may also have been selection bias if oral contraceptive users were under more intensive medical surveillance. It has not been possible to reconcile the findings of the various studies to date, including the authors' earlier results showing no association. The latter results were derived from data collected using methods almost identical to those used in the present study. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/2912040/Breast_cancer_before_age_45_and_oral_contraceptive_use:_new_findings_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/oxfordjournals.aje.a115132 DB - PRIME DP - Unbound Medicine ER -