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Function of the myogenic regulatory factors Myf5, MyoD, Myogenin and MRF4 in skeletal muscle, satellite cells and regenerative myogenesis.
Semin Cell Dev Biol. 2017 12; 72:19-32.SC

Abstract

Discovery of the myogenic regulatory factor family of transcription factors MYF5, MYOD, Myogenin and MRF4 was a seminal step in understanding specification of the skeletal muscle lineage and control of myogenic differentiation during development. These factors are also involved in specification of the muscle satellite cell lineage, which becomes the resident stem cell compartment inadult skeletal muscle. While MYF5, MYOD, Myogenin and MRF4 have subtle roles in mature muscle, they again play a crucial role in directing satellite cell function to regenerate skeletal muscle: linking the genetic control of developmental and regenerative myogenesis. Here, I review the role of the myogenic regulatory factors in developing and mature skeletal muscle, satellite cell specification and muscle regeneration.

Authors+Show Affiliations

King's College London, Randall Centre for Cell and Molecular Biophysics, London, SE1 1UL, UK. Electronic address: peter.zammit@kcl.ac.uk.

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29127046

Citation

Zammit, Peter S.. "Function of the Myogenic Regulatory Factors Myf5, MyoD, Myogenin and MRF4 in Skeletal Muscle, Satellite Cells and Regenerative Myogenesis." Seminars in Cell & Developmental Biology, vol. 72, 2017, pp. 19-32.
Zammit PS. Function of the myogenic regulatory factors Myf5, MyoD, Myogenin and MRF4 in skeletal muscle, satellite cells and regenerative myogenesis. Semin Cell Dev Biol. 2017;72:19-32.
Zammit, P. S. (2017). Function of the myogenic regulatory factors Myf5, MyoD, Myogenin and MRF4 in skeletal muscle, satellite cells and regenerative myogenesis. Seminars in Cell & Developmental Biology, 72, 19-32. https://doi.org/10.1016/j.semcdb.2017.11.011
Zammit PS. Function of the Myogenic Regulatory Factors Myf5, MyoD, Myogenin and MRF4 in Skeletal Muscle, Satellite Cells and Regenerative Myogenesis. Semin Cell Dev Biol. 2017;72:19-32. PubMed PMID: 29127046.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Function of the myogenic regulatory factors Myf5, MyoD, Myogenin and MRF4 in skeletal muscle, satellite cells and regenerative myogenesis. A1 - Zammit,Peter S, Y1 - 2017/11/15/ PY - 2017/08/15/received PY - 2017/11/03/revised PY - 2017/11/06/accepted PY - 2017/11/12/pubmed PY - 2018/7/25/medline PY - 2017/11/12/entrez KW - MRF4 KW - Myf5 KW - MyoD KW - Myogenin KW - Regeneration KW - Satellite cell KW - Skeletal muscle SP - 19 EP - 32 JF - Seminars in cell & developmental biology JO - Semin Cell Dev Biol VL - 72 N2 - Discovery of the myogenic regulatory factor family of transcription factors MYF5, MYOD, Myogenin and MRF4 was a seminal step in understanding specification of the skeletal muscle lineage and control of myogenic differentiation during development. These factors are also involved in specification of the muscle satellite cell lineage, which becomes the resident stem cell compartment inadult skeletal muscle. While MYF5, MYOD, Myogenin and MRF4 have subtle roles in mature muscle, they again play a crucial role in directing satellite cell function to regenerate skeletal muscle: linking the genetic control of developmental and regenerative myogenesis. Here, I review the role of the myogenic regulatory factors in developing and mature skeletal muscle, satellite cell specification and muscle regeneration. SN - 1096-3634 UR - https://www.unboundmedicine.com/medline/citation/29127046/Function_of_the_myogenic_regulatory_factors_Myf5_MyoD_Myogenin_and_MRF4_in_skeletal_muscle_satellite_cells_and_regenerative_myogenesis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1084-9521(17)30366-X DB - PRIME DP - Unbound Medicine ER -